USD MED: NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR

USD MED：适应性行为的神经机制

• 批准号: 7627575
• 负责人: JOYCE KEIFER
• 金额: $ 101.8万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627575
• 关键词: Accounting; Adaptive Behaviors; Address; Anxiety Disorders; Behavior; Behavioral; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Environment; Equipment; Faculty; Funding; Glutamate Receptor; Goals; Grant; Hippocampus (Brain); Injury; Institution; Invertebrates; Lasers; Learning; Memory; Mental disorders; Microscope; Modeling; Motor; Nervous system structure; Neural Pathways; Neuraxis; Neurosciences; Process; RNA Interference; Rattus; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Scanning; Schizophrenia; Sensory; Source; South Dakota; Stress; United States National Institutes of Health; Universities; addiction; classical conditioning; experience; member; neural circuit; neurochemistry; neuromechanism; novel; response; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center on NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR at the University of South Dakota is organized to understand how the nervous system adapts behavior to changes in the environment. The main aim of our Center is to study the structural reorganization of neural pathways that results in adaptive behavioral responses to novel sensory-motor experiences. Functional reorganization of neural circuits is fundamental to processes that occur during learning and memory, development, and in the central nervous system's response to stress, and during disease states such as occurs following injury to the CNS and in mental illness. Our COBRE has five primary research projects that address the problem of sensorimotor adaptation. These include Dr. Timothy Clark who studies mechanisms of plasticity in the hippocampus. Dr. Pat Manzerra who studies glutamate receptor mechanisms underlying schizophrenia in a rat model. Dr. Brian Burrell who studies cellular mechanisms of associative learning in invertebrates. Dr. Pat Ronan who examines the role of RNAi in stress regulation. Drs. Forster and Watt who study the neurochemical effects of stress and their relation to addiction and anxiety disorders. Together, the main goal of these projects is to contribute to an understanding of the cellular mechanisms that underlie adaptive behavior and to develop a comprehensive theory that accounts for changes occurring at the cellular level during adaptive motor responses. The Center allows USD researchers to acquire new equipment such as a laser scanning confocal microscope, to enhance faculty development, and most importantly, to build infrastructure in neuroscience by the addition of new faculty members.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 组织了南达科他大学的自适应行为神经机制中心，以了解神经系统如何适应环境变化的行为。 我们中心的主要目的是研究神经途径的结构重组，从而导致对新型感觉运动体验的适应性行为反应。 神经回路的功能重组是学习和记忆，发展以及中枢神经系统对压力的反应以及在疾病状态（例如CNS伤害和精神疾病）发生的疾病状态中发生的过程的基础。 我们的毛绒有五个主要的研究项目，可以解决感觉运动适应性问题。其中包括蒂莫西·克拉克（Timothy Clark）博士，研究海马中可塑性的机制。 Pat Manzerra博士研究大鼠模型中精神分裂症基础的谷氨酸受体机制。 Brian Burrell博士研究了无脊椎动物中关联学习的细胞机制。 帕特·罗南（Pat Ronan）博士研究了RNAi在压力调节中的作用。 博士。研究压力的神经化学作用及其与成瘾和焦虑症的关系。总之，这些项目的主要目标是有助于理解基于适应性行为的细胞机制，并开发了一种全面的理论，该理论说明了自适应运动反应期间在细胞水平上发生的变化。 该中心允许美元研究人员购买新设备，例如激光扫描共聚焦显微镜，以增强教师的发展，最重要的是，通过增加新教师的成员来建立神经科学中的基础设施。