USD MED: NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR

USD MED：适应性行为的神经机制

• 批准号: 7959605
• 负责人: JOYCE KEIFER
• 金额: $ 45.6万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959605
• 关键词: Accounting; Adaptive Behaviors; Address; Anxiety Disorders; Behavior; Behavioral; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Environment; Equipment; Faculty; Funding; Glutamate Receptor; Goals; Grant; Hippocampus (Brain); Injury; Institution; Invertebrates; Lasers; Learning; Memory; Mental disorders; Microscope; Modeling; Motor; Nervous system structure; Neural Pathways; Neuraxis; Neurosciences; Process; RNA Interference; Rattus; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Scanning; Schizophrenia; Sensory; Source; South Dakota; Stress; United States National Institutes of Health; Universities; addiction; classical conditioning; experience; member; neural circuit; neurochemistry; neuromechanism; novel; response; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center on NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR at the University of South Dakota is organized to understand how the nervous system adapts behavior to changes in the environment. The main aim of our Center is to study the structural reorganization of neural pathways that results in adaptive behavioral responses to novel sensory-motor experiences. Functional reorganization of neural circuits is fundamental to processes that occur during learning and memory, development, and in the central nervous system's response to stress, and during disease states such as occurs following injury to the CNS and in mental illness. Our COBRE has five primary research projects that address the problem of sensorimotor adaptation. These include Dr. Timothy Clark who studies mechanisms of plasticity in the hippocampus. Dr. Pat Manzerra who studies glutamate receptor mechanisms underlying schizophrenia in a rat model. Dr. Brian Burrell who studies cellular mechanisms of associative learning in invertebrates. Dr. Pat Ronan who examines the role of RNAi in stress regulation. Drs. Forster and Watt who study the neurochemical effects of stress and their relation to addiction and anxiety disorders. Together, the main goal of these projects is to contribute to an understanding of the cellular mechanisms that underlie adaptive behavior and to develop a comprehensive theory that accounts for changes occurring at the cellular level during adaptive motor responses. The Center allows USD researchers to acquire new equipment such as a laser scanning confocal microscope, to enhance faculty development, and most importantly, to build infrastructure in neuroscience by the addition of new faculty members.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 南达科他大学适应性行为神经机制中心的目的是了解神经系统如何使行为适应环境的变化。 我们中心的主要目标是研究神经通路的结构重组，从而对新的感觉运动体验产生适应性行为反应。 神经回路的功能重组对于学习和记忆、发育、中枢神经系统对压力的反应以及疾病状态（例如中枢神经系统损伤后和精神疾病）期间发生的过程至关重要。 我们的 COBRE 有五个主要研究项目来解决感觉运动适应问题。其中包括研究海马体可塑性机制的蒂莫西·克拉克博士。 Pat Manzerra 博士在大鼠模型中研究精神分裂症的谷氨酸受体机制。 Brian Burrell 博士研究无脊椎动物联想学习的细胞机制。 Pat Ronan 博士研究 RNAi 在压力调节中的作用。 博士。福斯特和瓦特研究压力对神经化学的影响及其与成瘾和焦虑症的关系。总之，这些项目的主要目标是促进对适应性行为背后的细胞机制的理解，并开发一种综合理论来解释适应性运动反应期间细胞水平上发生的变化。 该中心允许美国研究人员购买激光扫描共焦显微镜等新设备，以加强教师发展，最重要的是，通过增加新教师来建设神经科学基础设施。