GENE FUNCTION

基因功能

• 批准号: 7609858
• 负责人: MICHAEL J KERN
• 金额: $ 25.79万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609858
• 关键词: Breeding; Categories; Computer Retrieval of Information on Scientific Projects Database; Funding; Future; Gene Targeting; Generations; Genotype; Grant; Institution; Mentors; Microinjections; Mus; Recruitment Activity; Research; Research Personnel; Resources; Source; Technology; Transgenic Mice; Transgenic Organisms; United States National Institutes of Health; concept; embryonic stem cell; falls; gene function; homologous recombination; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall responsibilities of the Transgenic Mouse Core fall into the following four categories: a)Generation of mice-transgenic mice will be generated by both pronuclear microinjection and homologous recombination in ES cells as needed for the five initial investigators and any future investigators recruited. b)Mentoring- the initial and future project leaders will be mentored in the utilization of transgenic and gene targeted technologies. c)Experimentation- all experiments that generate and/or use transgenic/gene targeted mice will be facilitated from concept to completion. d)Utilization of mice- all genetically modified mice will be maintained in the core to facilitate and consolidate breeding, genotyping, and recordkeeping of the mice.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 转基因小鼠核心的总体职责分为以下四类： a)小鼠的产生-转基因小鼠将通过双原核显微注射产生 根据五名初始研究人员和任何未来招募的研究人员的需要，在 ES 细胞中进行同源重组。 b) 指导——初始和未来的项目领导者将在使用 转基因和基因靶向技术。 c) 实验——产生和/或使用转基因/基因靶向小鼠的所有实验 从概念到完成都将得到便利。 d) 小鼠的利用——所有转基因小鼠将保留在核心中 促进和巩固小鼠的育种、基因分型和记录保存。