Improving Diagnostic and Management Tools for Neurocysticercosis (Peru-JHU TMRC Program)

改进神经囊尾蚴病的诊断和管理工具（秘鲁-JHU TMRC 计划）

• 批准号: 9913450
• 负责人: Hector Hugo Garcia
• 金额: $ 53.61万
• 依托单位: UNIVERSIDAD PERUANA CAYETANO HEREDIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913450
• 关键词: Animal Model; Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Biological Markers; Biostatistics Core; Brain; Brain Injuries; Cessation of life; Clinical Trials; Code; Cyst; Cysticercosis; Development; Diagnosis; Diagnostic; Diagnostic tests; Early Diagnosis; Encephalitis; Endemic Diseases; Enhancing Lesion; Ensure; Epilepsy; Ethics; Foundations; Frequencies; General Population; Human; In Vitro; Individual; Inflammation; International; Libraries; Modeling; Molecular Biology Techniques; Monitor; Morbidity - disease rate; Neurocysticercosis; Parasites; Peru; Peruvian; Predictive Value; Principal Investigator; Process; Public Health; Regulation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Scheme; Secondary to; Seizures; Sensitivity and Specificity; Solid; Taenia solium; Technology; Testing; Translating; Treatment Efficacy; Work; animal care; data management; diagnostic assay; genomic data; improved; in vitro Model; nanoparticle; novel diagnostics; programs; screening; tool

Improving Diagnostic and Management Tools for Human Cysticercosis / Perú-JHU TMRC PROGRAM OVERVIEW Principal Investigator / Program Director (last, middle, first): GARCIA, Héctor H. Improving Diagnostic and Management Tools for Neurocysticercosis (Perú-JHU TMRC Program) PROJECT SUMMARY Taenia solium neurocysticercosis continues to be a major cause of seizures and epilepsy in most of the world. Our group has continuously worked in NCC for the last 25 years and has provided landmark contributions to its study, diagnosis, and treatment. This TMRC application builds on a recent ICIDR application and uses resources developed and acquired over this period including sample libraries, in vitro and animal models (including three new models recently developed in our settings) and recently available nanoparticle diagnostics and genomic data. Our objective is to provide improved diagnostics and monitoring as well as more efficient antiparasitic and antiinflammatory therapies in order to minimize brain damage which follows parasite death. Early diagnosis and improved treatment should result in reduced frequency of epilepsy secondary to NCC. The Perú-JHU TMRC application frames three component Research Projects and three Cores to provide a fully functional research network and take advantage of the endemicity of the disease and our existing, highly successful research network in Perú. The scientific core will serve as the foundation to be used by the two research projects, and will include capacities for in vitro and animal models, molecular biology techniques, and analytic processes, and will be supported by the Data Management and Biostatistics Core. An Administrative Core including Ethics and Animal Care units will ensure full compliance with local and international research codes and regulations. Three projects comprise the program: The three research projects are Component 1 - Improved Diagnostics Assays for Viable or Degenerating Neurocysticercosis; Component 2 - Biomarkers for Monitoring Treatment Efficacy in Human Neurocysticercosis, and Component 3 - Improving the Understanding and Treatment of Brain Inflammation in Neurocysticercosis. The Program will take advantage of the specific objectives of these research projects to provide a unified set of promising tools ready to be tested in clinical trials and translated to human use.

改进人类囊尾蚴病的诊断和管理工具 / Perú-JHU TMRC 项目概述 首席研究员/项目总监（最后、中间、第一）：GARCIA, Héctor H. 改进神经囊尾蚴病的诊断和管理工具 （秘鲁-JHU TMRC 项目） 项目概要 猪带绦虫神经囊尾蚴病仍然是大多数国家癫痫发作和癫痫的主要原因 过去 25 年来，我们的团队一直在 NCC 工作，并提供了具有里程碑意义的成果。 对其研究、诊断和治疗的贡献 该 TMRC 应用程序建立在最近的 ICIDR 基础上。 应用程序并使用在此期间开发和获得的资源，包括样本库、体外 和动物模型（包括最近在我们的环境中开发的三个新模型）和最近可用的 我们的目标是提供改进的诊断和监测。 以及更有效的抗寄生虫和抗炎疗法，以尽量减少脑损伤 寄生虫死亡后的早期诊断和改进治疗应可减少寄生虫发生的频率。 继发于 NCC 的癫痫。 秘鲁-JHU TMRC 申请框架包括三个组成部分的研究项目和三个核心 提供功能齐全的研究网络，并利用该疾病的流行性和我们的 秘鲁现有的、非常成功的研究网络将作为其科学核心的基础。 由两个研究项目使用，并将包括体外和动物模型、分子 生物学技术和分析过程，并将得到数据管理和 生物统计核心。包括道德和动物护理部门的行政核心将确保完全合规。 该计划包括三个项目： 这三个研究项目是第 1 部分 - 改进可行或可行的诊断分析 退化性神经囊尾蚴病；第 2 部分 - 用于监测人类治疗效果的生物标志物 神经囊尾蚴病和第 3 部分 - 提高对脑部炎症的理解和治疗 该计划将利用这些研究项目的具体目标。 提供一套统一的有前途的工具，准备在临床试验中进行测试并转化为人类使用。