NUTRITION SUPPORT IN PEDIATRIC STEM CELL TRANSPLANTATION - A RCT

儿科干细胞移植中的营养支持 - 随机对照试验

• 批准号: 7607255
• 负责人: CHRISTOPHER P DUGGAN
• 金额: $ 11.08万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607255
• 关键词: Affect; Body Composition; Calories; Child; Childhood; Complication; Computer Retrieval of Information on Scientific Projects Database; Energy Intake; Energy Metabolism; Funding; Grant; Indirect Calorimetry; Institution; Lead; Measures; Methods; Mucositis; Nutritional; Nutritional Support; Parenteral Nutrition; Patients; Proteins; Randomized Controlled Trials; Research; Research Personnel; Resources; Rest; Source; Spiral Computed Tomography; Standards of Weights and Measures; Stem cell transplant; Treatment Protocols; United States National Institutes of Health; gastrointestinal; nutrition; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims/Objectives: Children undergoing stem cell transplantation often require parenteral nutrition to provide adequate calories and protein due to severe mucositis and other gastrointestinal complication of the preparative regimen. Accurate provision of energy may reduce complications related to overfeeding or underfeeding. We hypothesize that changes in body composition during SCT affect REE, and that the standard approach to nutritional management of these patients may lead to overfeeding. We propose a prospective, randomized controlled trial to compare the nutritional effects of the standard method of nutritional support with an approach in which energy intake is provided to exactly meet resting energy expenditure as measured by indirect calorimetry.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 具体目的/目标： 由于准备方案的严重粘膜炎和其他胃肠道并发症，接受干细胞移植的儿童通常需要肠外营养以提供足够的热量和蛋白质。 准确的能量供应可以减少与过量喂养或喂养不足相关的并发症。 我们假设 SCT 期间身体成分的变化会影响 REE，并且这些患者的标准营养管理方法可能会导致过度喂养。 我们提出了一项前瞻性、随机对照试验，以比较标准营养支持方法与通过间接量热法测量的精确满足静息能量消耗的能量摄入方法的营养效果。