METABOLIC EFFECTS OF SHORT-TERM WALNUT CONSUMPTION IN METABOLIC SYDROME

短期食用核桃对代谢综合征的代谢影响

• 批准号: 7606976
• 负责人: CHRISTOS S MANTZOROS
• 金额: $ 1.29万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606976
• 关键词: Arginine; Biological Markers; Blood Vessels; Body Weight; Computer Retrieval of Information on Scientific Projects Database; Consumption; Cross-Over Studies; Depth; Fatty acid glycerol esters; Funding; Grant; Health; Inflammatory; Institution; Juglans; Lipids; Macronutrients Nutrition; Magnesium; Metabolic; Metabolic syndrome; Micronutrients; Nutrient; Nuts; Observational Study; Outcome; Phytochemical; Placebo Control; Research; Research Personnel; Resources; Source; Trees; United States National Institutes of Health; Woman; cardiovascular disorder risk; insulin sensitivity; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extensive epidemiologic evidence suggests that nut consumption decreases cardiovascular disease risk (CVD) and CVD outcomes. Tree nuts have some similar attributes, but differ in their magnesium, L-arginine, omega-three and other fat fractions. Walnuts have an optimal nutrient content to exert positive health effects. Walnuts have been shown to have a favorable effect on lipid profile and vascular reactivity but these effects alone do not explain the positive health effects observed in observational studies. In addition, the effect of walnuts on the metabolic syndrome as a whole has never been studied. To date the mechanisms of the effects of walnuts on inflammatory biomarkers, body weight and insulin sensitivity remain unknown. Walnuts include many potentially beneficial micronutrients and phytochemicals and in this study we propose to examine the effects of walnuts independent of macronutrient content. We plan to perform a placebo controlled cross-over study to examine in depth the short-term effects of walnut consumption in men and women with the metabolic syndrome.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 广泛的流行病学证据表明，坚果消耗降低了心血管疾病风险（CVD）和CVD结果。树坚果具有一些相似的属性，但其镁，L-精氨酸，欧米茄和其他脂肪分数有所不同。 核桃具有最佳的养分含量，可以发挥积极的健康影响。核桃已被证明对脂质谱和血管反应性具有良好的影响，但仅这些作用并不能解释观察性研究中观察到的阳性健康效应。此外，从未研究过核桃对整个代谢综合征的影响。迄今为止，核桃对炎症生物标志物，体重和胰岛素敏感性的作用机制尚不清楚。核桃包括许多潜在的有益的微量营养素和植物化学物质，在这项研究中，我们建议检查核桃的作用，而不是与大量营养素含量无关。我们计划进行安慰剂控制的跨界研究，以深入研究核桃消费量对患有代谢综合征的男性和女性的短期影响。