CLINICAL TRIAL: LEPTIN (R-METHULEPTIN) FOR THE TREATMENT OF HYPOTHALAMIC AMENHOR

临床试验：瘦素（R-甲基瘦素）治疗下丘脑 Amenhor

• 批准号: 7718894
• 负责人: CHRISTOS S MANTZOROS
• 金额: $ 1.15万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718894
• 关键词: Amenorrhea; Bone Density; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Hormones; Hypothalamic structure; Immunologics; Institution; Leptin; Physiological; Randomized; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Well in self; Woman; bone; double-blind placebo controlled trial; gonad function; improved; recombinant methionyl human leptin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The broad goal of this study is to perform a randomized, double-blind, placebo-controlled trial of r-metHuLeptin administration in women with hypothalamic amenorrhea (HA) to determine whether restoring physiologic leptin levels in women with HA will improve bone density, gonadal function, hormone levels, bone markers, overall sense of well-being, and immunologic parameters.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的广泛目的是在患有下丘脑闭经（HA）的女性中进行R-杀菌蛋白给药的随机，双盲，安慰剂对照试验，以确定HA女性中恢复生理学的瘦素水平是否会改善骨密度，性腺功能，性腺功能，激素标志，骨骼标记，整体良好，良好的bebe和免疫学参数。