PSYCHOLOGICAL FACTORS AND GYNECOLOGICAL DISEASE

心理因素与妇科疾病

• 批准号: 7627549
• 负责人: ROBERT G BRZYSKI
• 金额: $ 0.46万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627549
• 关键词: Age; Age-Years; Androgens; Anxiety; Biochemical Markers; Body mass index; Caring; Clinic; Clinical; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Depression screen; Discipline of obstetrics; Disease; Emotional; Enrollment; Epidemiologic Studies; Female Genital Diseases; Frequencies; Funding; Gonadotropins; Grant; Gynecologic; Hirsutism; Infertility; Inpatients; Institution; Insulin Resistance; Laboratories; Laparoscopy; Measures; Mental Depression; Mental disorders; Obesity; Outpatients; Pathologic; Patients; Pelvic Pain; Polycystic Ovary Syndrome; Post-Traumatic Stress Disorders; Prevalence; Psychiatric Diagnosis; Psychiatry; Psychological Factors; Publishing; Recording of previous events; Reporting; Research; Research Personnel; Resources; Score; Screening procedure; Series; Serum; Severities; Severity of illness; Source; Sterilization for infection control; Symptoms; United States National Institutes of Health; Woman; chronic pain; chronic pelvic pain; clinically relevant; comparison group; day; improved; psychologic; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVES: 1) To evaluate the prevalence and severity of psychological symptoms in gynecologic patients with chronic pelvic pain (CPP) or polycystic ovary syndrome (PCOS). 2) To correlate the severity of the psychological symptoms with clinical and laboratory measures of the severity of the gynecologic disease. RESEARCH PLAN: In this study we will administer the Havard Department of Psychiatry/National Depression Screening Day Scale (HANDS) psychological screening tool and/or the Center for Epidemiologic Studies-Depression (CES-D) scale to gynecologic patients. Women over 18 years of age seen in our gynecologic inpatient or outpatient settings or enrolled in ongoing studies will be invited to participate. METHODS: For the portion of the study involving PCOS, scores on the HANDS) screening tool and/or the CES-S scale will be compared to scores for age and body mass index (BMI) matched controls as well as for age-matched controls with infertility. HANDS) and/or CES-D score in PCOS patients will also be correlated with measures of disease severity including BMI, menstrual frequency, obstetric history, hirsutism score, serum androgens, serum gonadotropins and insulin resistance. These measures of severity will be obtained from patient charts. For the portion of the study involving CPP, the HANDS) screening tool will be administered to women with CPP undergoing diagnostic laparoscopy as part of routine clinical care. The screening tool will also be administered to two control groups: 1) women without pelvic pain undergoing elective laparoscopic sterilization and 2) women without pelvic pain seen in our patient clinics. Scores between groups will be compared. Scores will also be correlated with pathologic findings at laparoscopy. CLINICAL RELEVANCE: Half of gynecologic outpatients have a significant emotional disease. Psychiatric diagnoses are common features of many gynecologic diseases. For example, depression scores on screening tools are higher in women with polycystic ovary syndrome (PCOS) compared to age matched healthy controls, and depression is frequently reported in published series of women with chronic pelvic pain (CPP). While the existence of depression in gynecologic patients is clear, the comparison groups in studies are frequently not optimally selected. For example, since obesity and infertility are common features of PCOS and since depression may be more prevalent in these populations, obese women and infertile women may be better control groups. It is also unclear whether depression is a result of chronic pain or causally related. Depression has also been shown to correlate with clinical and biochemical markers of gynecologic disease, however, it is unknown whether treating the gynecologic disease improves depression. We hypothesize that psychological disorders, such as depression, anxiety and post-traumatic stress disorder (PTSD) are more common in certain gynecologic diseases, such as chronic pelvic pain (CPP) and polycystic ovary syndrome (PCOS), and these psychological disorders correlate with measures of severity in the gynecologic diseases.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目标： 1）评估慢性骨盆疼痛（CPP）或多囊卵巢综合征（PCOS）的妇科患者心理症状的患病率和严重程度。 2）将心理症状的严重程度与妇科疾病严重程度的临床和实验室措施相关联。 研究计划：在这项研究中，我们将对妇科患者进行HAVARD精神病学/国家抑郁筛查日量表（Hands）心理筛查工具和/或流行病学研究 - 抑郁症（CES-D）量表的中心。 在我们的妇科住院或门诊环境或正在进行的研究中，将邀请18岁以上的妇女参加。 方法：对于涉及PCOS的研究部分，将比较筛选工具和/或CES-S量表与年龄和体重指数（BMI）匹配的对照组以及具有不育的年龄匹配的对照组的评分。 PCOS患者中的手）和/或CES-D评分也将与疾病严重程度的测量相关，包括BMI，月经频率，产科历史，毛肌评分，血清雄激素，血清促性腺激素和胰岛素抵抗。 这些严重程度的度量将从患者图表中获得。 对于涉及CPP的研究部分，将向患有腹腔镜诊断性腹腔镜检查的CPP女性提供筛查工具，作为常规临床护理的一部分。 筛查工具还将针对两个对照组进行管理：1）腹腔镜灭菌经过骨盆疼痛的女性，以及2）在我们的患者诊所中看到的没有骨盆疼痛的妇女。 将比较组之间的分数。 分数也将与腹腔镜检查时的病理发现相关。 临床相关性：一半的妇科门诊患者患有明显的情绪疾病。 精神病诊断是许多妇科疾病的常见特征。 例如，与年龄相匹配的健康对照组相比，多囊卵巢综合征（PCOS）的女性筛查工具上的抑郁评分更高，并且在发表的一系列慢性骨盆疼痛（CPP）系列中经常报道抑郁症。 虽然妇科患者的抑郁症的存在很明显，但研究中的比较组通常不是最佳选择。 例如，由于肥胖和不育是PCOS的常见特征，并且由于这些人群可能更普遍，因此肥胖女性和不育女性可能是更好的对照组。 尚不清楚抑郁症是慢性疼痛还是因果关系相关的结果。 抑郁症也已显示与妇科疾病的临床和生化标志物相关，但是，尚不清楚治疗妇科疾病是否可以改善抑郁症。 我们假设心理疾病，例如抑郁症，焦虑和创伤后应激障碍（PTSD）在某些妇科疾病中更为常见，例如慢性骨盆疼痛（CPP）和多囊产卵综合征（PCOS），以及这些心理疾病与这些心理疾病与这些心理疾病的严重性相关。