SURGICAL WEIGHT LOSS INTERVENTION IN SLEEP APNEA

睡眠呼吸暂停的手术减肥干预

• 批准号: 7607458
• 负责人: Alan R. Schwartz
• 金额: $ 1.21万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607458
• 关键词: Body Weight decreased; Computer Retrieval of Information on Scientific Projects Database; Development; Dose; Funding; Goals; Grant; Institution; Metabolic; Obesity; Obstructive Sleep Apnea; Operative Surgical Procedures; Physiological; Protocols documentation; Research; Research Personnel; Resources; Risk Factors; Severities; Sleep Apnea Syndromes; Source; United States National Institutes of Health; relating to nervous system; response; weight loss intervention

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodic occlusion of the upper airway is the most common cause of obstructive sleep apnea (OSA). The strongest risk factor for the development of increased airway collapsibility, and consequent OSA, is obesity. Similarly, weight loss is known to decrease the severity of OSA. To date, it is not clear if there is a dose-response relationship between weight loss and improvement in OSA. The factors involved in weight loss-induced improvements in OSA also remain to be elucidated. The goals of the present protocol are to: 1)determine the association between sleep disordered breathing (SDB) and upper airway physiologic, anthropometric and metabolic parameters; 2)determine the relationship between the degree of weight loss and a)the severity of sleep disordered breathing b)decreases in upper airway collapsibility after weight loss c)other neural, metabolic, anthropometric and physiologic predictors

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 上呼吸道的周期性阻塞是阻塞性睡眠呼吸暂停（OSA）的最常见原因。 肥胖是肥胖的最大风险因素，而OSA则是肥胖。 同样，已知体重减轻会降低OSA的严重程度。 迄今为止，尚不清楚体重减轻与OSA改善之间是否存在剂量反应关系。 减肥引起的改善的因素也尚待阐明。 本协议的目标是： 1）确定睡眠障碍呼吸（SDB）与上气道生理，人体测量和代谢参数之间的关联； 2）确定减肥程度与 a）睡眠失调的呼吸严重程度 b）减肥后的上呼吸道可折叠性降低 c）其他神经，代谢，人体测量和生理预测因子