ACT 2 PROJ 2 LONGEVITY FOODS AND OBESITY-ASSOCIATED INSULIN RESISTANCE

行动 2 项目 2 长寿食品和肥胖相关的胰岛素抵抗

• 批准号: 7959178
• 负责人: Pratibha V Nerurkar
• 金额: $ 12.36万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959178
• 关键词: Adipocytes; Adverse effects; American; Asians; Body Weight decreased; CCL4 gene; Cardiovascular Diseases; Chronic Disease; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Consumption; Diabetes Mellitus; Diet; Drug Interactions; Dyslipidemias; Epidemic; Failure; Food; Funding; Goals; Grant; Heart Diseases; In Vitro; Institution; Insulin Resistance; Intake; Intervention; Japanese Population; Link; Longevity; Medical; Melons; Minority; Molecular Target; Momordica charantia; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcomes Research; PPAR gamma; Pharmaceutical Preparations; Population; Research; Research Personnel; Resources; Source; Surgeon; Translating; Treatment Protocols; United States; United States National Institutes of Health; Vegetables; Weight Gain; diabetic; fruits and vegetables; functional food; in vivo; lifestyle factors; prevent; therapeutic development; Adipocytes; Adverse effects; American; Asians; Body Weight decreased; CCL4 gene; Cardiovascular Diseases; Chronic Disease; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Consumption; Diabetes Mellitus; Diet; Drug Interactions; Dyslipidemias; Epidemic; Failure; Food; Funding; Goals; Grant; Heart Diseases; In Vitro; Institution; Insulin Resistance; Intake; Intervention; Japanese Population; Link; Longevity; Medical; Melons; Minority; Molecular Target; Momordica charantia; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcomes Research; PPAR gamma; Pharmaceutical Preparations; Population; Research; Research Personnel; Resources; Source; Surgeon; Translating; Treatment Protocols; United States; United States National Institutes of Health; Vegetables; Weight Gain; diabetic; fruits and vegetables; functional food; in vivo; lifestyle factors; prevent; therapeutic development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity has reached epidemic proportions in the United States and is closely linked to type 2 diabetes and cardiovascular disease (CVD), leading the Surgeon General to issue a call for a national effort not only to identify the causes of obesity, but also to outline effective and culturally appropriate interventions. Efficacies of current therapies for obesity are complicated due to inability to maintain long-term weight loss, while those for type 2 diabetes are prone to drug-drug interactions and various side effects, such as additional weight gain and secondary failure. Interestingly, the occurrence of chronic diseases, such as diabetes and heart disease, among Okinawan Japanese is only one fifth that of Americans. Among the various lifestyle factors are lower calorie intake and high consumption of fruits and vegetables. The long-term goal of this research is to investigate the efficacy of medicinal/functional foods to prevent and/or ameliorate obesity-associated insulin resistance, diabetic dyslipidemia and CVDs, and to identify the underlying mechanisms. This project aims to identify specific molecular targets and delineate the mechanisms involved in ameliorating obesity-associated insulin resistance, using Momordica charantia (bitter melon, BM), an Asian vegetable. The specific aim of the project in year three was to investigate Sirt-PPARgamma-NCoR interactions in adipocytes. We expect to translate the results of the in vitro and in vivo studies to clinical trials among minority populations with obesity and/or type 2 diabetes mellitus. Such studies may have a significant impact on the development of therapeutic regimens that can be incorporated into the daily diet.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 肥胖症已经在美国达到了流行比例，与2型糖尿病和心血管疾病（CVD）密切相关，导致外科医生发出呼吁，不仅要确定肥胖症的原因，而且还概述了有效和文化上适当的干预措施。由于无法维持长期体重减轻，目前肥胖治疗的疗效是复杂的，而2型糖尿病的疗法则容易受药物相互作用和各种副作用，例如额外的体重增加和次要衰竭。有趣的是，在冲绳日本人中，慢性疾病（例如糖尿病和心脏病）的发生仅是美国人的五分之一。在各种生活方式因素中，较低的卡路里摄入量和水果和蔬菜的高消耗量。这项研究的长期目标是研究药物/功能性食品的功效，以预防和/或改善与肥胖相关的胰岛素抵抗，糖尿病血脂异常和CVD，并识别基本机制。该项目旨在使用亚洲蔬菜（一种亚洲植物）使用Momordica Charantia（Bitter Melon，BM）来确定特定的分子靶标，并描述与肥胖相关的胰岛素抵抗相关的机制。该项目在第三年的具体目的是研究脂肪细胞中的SIRT-PPARGAMMA-NCOR相互作用。 我们期望将体外和体内研究的结果转化为肥胖和/或2型糖尿病少数族裔的临床试验。这样的研究可能会对可以纳入日常饮食的治疗方案的发展产生重大影响。