DEFICIENCY OF THE HDL RECEPTOR, SR-BI, IN HUMANS

人类 HDL 受体 SR-BI 缺乏

• 批准号: 7607476
• 负责人: Annabelle Rodriguez
• 金额: $ 0.96万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607476
• 关键词: Asses; Atherosclerosis; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Dyslipidemias; Family; Funding; Genes; Goals; Grant; HDL cholesteryl ester; High Density Lipoprotein Cholesterol; High Density Lipoproteins; Human; Individual; Institution; Knockout Mice; LDL Cholesterol Lipoproteins; Lipoproteins; Low-Density Lipoproteins; Observational Study; Patients; Research; Research Personnel; Resources; Risk; Role; Source; Study Subject; Syndrome; United States National Institutes of Health; Variant; Work; concept; insight; macrophage; receptor; scavenger receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Most observational studies support the concept that the desirable levels of HDL cholesterol are inversely correlated to cardiovascular disease even in the presence of elevated LDL cholesterol. Nonetheless, a subset of patients with desirable HDL and elevated LDL levels are at increase risk for CVD. Studies in one family and knockout mice deficient in the HDL scavenger receptor, SR-B1, recapitulate this dyslipidemic (elevated HDL and LDL) syndrome with increased CVD. These investigators hypothesize that a subset of individuals with elevated HDL and LDL will be SR-B1 deficient. Three specific aims will be examined 1) characterize the lipoprotein composition and fractional clearance of HDL-cholesterol ester in subjects with elevated HDL and LDL cholesterol; 2)asses SR-B1 function and expression in macrophages derived from study subjects 3)identify variant within the SR-B1 gene in study subjects. The overarching goal of this work is to provide new insights into the role of SR-B1 in human dyslipidemia and atherosclerosis and challenge the concept that "desirable" HDL cholesterol levels are always cardioprotective.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 大多数观察性研究都支持这样一个概念，即即使在LDL胆固醇升高的情况下，HDL胆固醇水平也与心血管疾病成反比。尽管如此，具有理想的HDL和LDL水平升高的患者的子集有CVD的风险增加。在HDL清道夫受体SR-B1缺乏缺乏的一个家庭和敲除小鼠中，概括了这种血脂异常（升高的HDL和LDL）综合征，CVD增加。这些研究者假设HDL和LDL升高的个体子集将是SR-B1缺乏。 将检查三个特定目标1）表征HDL和LDL胆固醇受试者中HDL-胆固醇酯的脂蛋白组成和分数清除率； 2）在研究对象中识别SR-B1基因内的变体的巨噬细胞中的SR-B1功能和表达。这项工作的总体目标是提供有关SR-B1在人类血脂异常和动脉粥样硬化中的作用的新见解，并挑战“理想”的HDL胆固醇水平始终是心脏保护的概念。