NBP

NBP

• 批准号: 7607832
• 负责人: THOMAS A MELLMAN
• 金额: $ 3.02万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607832
• 关键词: Adrenergic Receptor; African American; American; Anger; Blood; Blood Pressure; Blood Pressure Monitors; Cardiovascular Physiology; Cardiovascular system; Clinical; Computer Retrieval of Information on Scientific Projects Database; Consent; Discrimination; Disease; European; Evaluation; Event; Exposure to; Funding; Genetic Polymorphism; Grant; Hypertension; Institution; Link; Measures; Medical; Medical History; Minority; Morbidity - disease rate; Participant; Patient Self-Report; Phase; Physiological; Post-Traumatic Stress Disorders; Prejudice; Rate; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Resources; Risk; Role; Severities; Sleep; Source; Symptoms; Toxicology; Trauma; United States National Institutes of Health; Urine; blood pressure regulation; depressive symptoms; experience; healthy volunteer; interest; response; salt intake; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There has been much recent interest in medical morbidity associated with posttraumatic stress disorder(PTSD). Cardiovascular response being a prominent feature of the physiological reactivity that is a core feature of the disorder raises the possibility of enduring effects on cardiovascular function. Studies are mixed as to whether PTSD is associated with an increased risk of hypertension and related cardiovascular morbidity. African Americans have higher rates of hypertension and its medical consequences than Americans of European ancestry. A close look at the relevant clinical and epidemiological research indicates that the studies that include minority participants tend to demonstrate a relationship between PTSD and hypertension and the subjects of a large study that failed to find this relationship were predominantely white. The proposed study aims investigate candidate mechanisms for linking PTSD to cardiovascular regulation and, in particular, the role of nocturnal blood pressure regulation along with hypothesized modifiers of the relationship of trauma exposure and nocturnal blood pressure including the role of trait anger and exposure to prejudice and discrimination. In a subsequent phase of the research we will also evaluate relationships to genetic polymorphisms of adrenergic receptors. Healthy volunteers and people who report having experinced a traumatic event and current endorse experiencing PTSD symptoms will be recruited to participate in the study. During their initial evaluation, all participants will complete self-report measures which assess for trauma exposure and PTSD related symptoms, depression, experiences of discrimination and prejudice, anger management, sensitivity of negative events, orientation towards pleasing others, dietary salt intake, and personal and medical history. Following initial assessment, consenting participants who meet criteria will complete a clinical review to further assess for intensity and severity of PTSD symptoms, physical exam and urine toxicology screen, overnight sleep recording, monitoring of blood pressure and activity level, and , in a subsequent phase of the research, a blood draws.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 最近，与创伤后应激障碍（PTSD）有关的医疗发病率引起了很多兴趣。心血管反应是该疾病的核心特征的生理反应性的重要特征，这增加了对心血管功能持久影响的可能性。研究是关于PTSD是否与高血压风险增加和相关心血管发病率的增加有关。与欧洲血统的美国人相比，非洲裔美国人的高血压及其医疗后果更高。仔细研究相关的临床和流行病学研究表明，包括少数群体参与者在内的研究倾向于证明PTSD与高血压之间的关系以及一项未能发现这种关系的大型研究的受试者主要是白人。拟议的研究旨在研究将PTSD与心血管调节联系起来的候选机制，尤其是夜间血压调节的作用以及假设的创伤暴露与夜间血压关系的修饰符，包括特征愤怒的作用以及对偏见和歧视的特质愤怒的作用。在随后的研究阶段，我们还将评估与肾上腺素能受体的遗传多态性的关系。 健康的志愿者和报告进行了经历过创伤事件和当前经历过PTSD症状的当前认可的人参加研究。在初步评估期间，所有参与者将完成自我报告措施，以评估创伤暴露和PTSD相关的症状，抑郁症，歧视和偏见的经历，愤怒管理，负面事件的敏感性，对他人取悦他人的敏感性，饮食盐的摄入量以及个人和个人和病史。经过初步评估后，符合标准的同意参与者将完成临床审查，以进一步评估PTSD症状，身体检查和尿液毒理学筛查的强度和严重程度，过夜睡眠记录，监测血压和活动水平，以及在随后的研究阶段，血液抽血。