EFFECT OF AGE ON INSULIN MEDIATED REGULATION OF GHRELIN

年龄对胰岛素介导的生长素释放肽调节的影响

• 批准号: 7606709
• 负责人: RALF M NASS
• 金额: $ 2.41万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606709
• 关键词: Abdomen; Acute; Age; Amino Acids; Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Eating; Elderly; Fatty acid glycerol esters; Funding; Grant; Homeostasis; Institution; Insulin; Laboratories; Measures; Mediating; Obesity; Octanoic Acids; Peptides; Plasma; Play; Post-Translational Protein Processing; Regulation; Research; Research Personnel; Resources; Role; Somatotropin; Source; Stomach; United States National Institutes of Health; Visceral; age effect; age related; caprylic acid; ghrelin; hydroxyl group; insulin sensitivity; Abdomen; Acute; Age; Amino Acids; Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Eating; Elderly; Fatty acid glycerol esters; Funding; Grant; Homeostasis; Institution; Insulin; Laboratories; Measures; Mediating; Obesity; Octanoic Acids; Peptides; Plasma; Play; Post-Translational Protein Processing; Regulation; Research; Research Personnel; Resources; Role; Somatotropin; Source; Stomach; United States National Institutes of Health; Visceral; age effect; age related; caprylic acid; ghrelin; hydroxyl group; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ghrelin, a peptide which is mainly derived from the stomach, is present in plasma in an active (acylated) and inactive (des-acylated) form. The major active form of ghrelin contains 28 amino acids with a unique post-translational modification: the hydroxyl group of ser3 is esterified by octanoic acid. The n-octanoyl group is essential for the GH (growth hormone) releasing activity. Plasma ghrelin plays a role in energy homeostasis, food intake, and possibly in GH release and obesity. To date, it is unclear how circulating ghrelin levels are regulated and whether there are age-specific differences in the regulation of ghrelin. Insulin sensitivity decreases with age. This is partially a result of the age-dependent increase in abdominal visceral fat. The studies proposed will investigate whether there are differences between young and older adults regarding the acute insulin mediated decrease in circulating ghrelin (bioactive, inactive form) levels. Using assays developed in our laboratory, both bioactive and inactive ghrelin will be measured.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 生长素是一种主要源自胃的肽，以活性（酰化）和非活性（DES-酰化）形式存在于血浆中。生长素的主要活性形式含有28种具有独特后翻译后修饰的氨基酸：Ser3的羟基由辛酸酯化。 N-八链酰基基团对于GH（生长激素）释放活性至关重要。血浆生长素素在能量稳态，食物摄入量以及可能在GH释放和肥胖症中发挥作用。迄今为止，尚不清楚如何调节循环的生长素素水平，以及生长素素调节的年龄特异性差异。胰岛素灵敏度随着年龄的增长而降低。这部分是由于年龄依赖性腹部内脏脂肪增加的结果。提出的研究将研究年轻人和老年人在急性胰岛素介导的循环生长素蛋白（生物活性，非活性形式）水平上是否存在差异。使用在我们的实验室中开发的测定，将测量生物活性和非活性生长素释放蛋白。