EFFECT OF GROWTH HORMONE TREATMENT ON RECOVERY FROM CUSHING'S DISEASE

生长激素治疗对库欣病康复的影响

• 批准号: 7606689
• 负责人: MARY L VANCE
• 金额: $ 6.06万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606689
• 关键词: Adrenal Glands; Aftercare; Benign; Body Composition; Bone Density; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Excision; Exercise; Fatty acid glycerol esters; Funding; Grant; High Blood Pressure; Hydrocortisone; Institution; Measures; Mental Depression; Metabolism; Muscle; Operative Surgical Procedures; Osteoporosis; Patients; Pituitary Gland; Pituitary Neoplasms; Pituitary-dependent Cushing' s disease; Placebos; Production; Purpose; Quality of life; Randomized; Rate; Recovery; Research; Research Personnel; Resources; Somatotropin; Source; United States National Institutes of Health; Weight Gain; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cushing's disease is excessive cortisol production caused by a benign tumor in the pituitary gland that stimulates the adrenal glands to produce too much cortisol causing weight gain, diabetes, high blood pressure, osteoporosis and depression in many patients. After successful removal of the pituitary tumor, recovery from Cushing's is often prolonged, usually at least one year. The purpose of this study is to determine if 1 or 2 years of growth hormone treatment after successful pituitary surgery accelerates the rate of recovery. The study involves the study of body composition (fat mass, muscle mass, bone density), exercise strength, metabolism and quality of life measures. Patients are randomized to receive either 1 or 2 years of growth hormone treatment to compare the rate of natural recovery with growth hormone treatment during the first year and the second year. Two thirds of patients receive growth hormone and one third of patients receive placebo during the first year; during the second year, all patients receive growth hormone.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 Cushing的疾病是垂体中良性肿瘤引起的皮质醇过多的产生，可刺激肾上腺产生过多的皮质醇，导致体重增加，糖尿病，高血压，骨质疏松症和许多患者的抑郁症。 成功清除垂体肿瘤后，从库欣的恢复通常会延长，通常至少一年。 这项研究的目的是确定成功的垂体手术后1或2年的生长激素治疗是否会加速恢复率。 该研究涉及对身体成分（脂肪质量，肌肉质量，骨密度），运动强度，代谢和生活质量测量的研究。 将患者随机接受1或2年的生长激素治疗，以将自然恢复率与第一年和第二年的生长激素治疗进行比较。 三分之二的患者接受生长激素，三分之一的患者在第一年接受安慰剂；在第二年，所有患者都接受生长激素。