IMPLANTED VAGUS NERVE STIMULATORS FOR SEVERE BULIMIA

植入迷走神经刺激器治疗严重贪食症

• 批准号: 7606013
• 负责人: PATRICIA L FARIS
• 金额: $ 0.67万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606013
• 关键词: Abstinence; Affect; Automobile Driving; Behavior; Belief; Binge Eating; Bulimia; Cognitive Therapy; Computer Retrieval of Information on Scientific Projects Database; Condition; Electric Stimulation; Frequencies; Funding; Grant; Implant; In complete remission; Individual; Institution; Mental disorders; Nerve; Numbers; Ondansetron; Patients; Pharmaceutical Preparations; Prevalence; Prosthesis; Range; Reporting; Research; Research Personnel; Resources; Severity of illness; Source; Stomach; System; Testing; United States National Institutes of Health; Vagus nerve structure; Vomiting; Woman; base; experience; implantation; purge; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bulimia nervosa is a serious psychiatric disease that occurs almost exclusively in women with a reported lifetime prevalence ranging from 1%-4%. The most common form of the illness is characterized by binge-eating followed by purging, usually in the form of self-induced vomiting with an accompanying loss of control over the behaviors. Treament usually consists of cognitive, behavioral therapy or antidepressent use. Because these treatments are only somewhat effective, especially for severely ill patients, there is a need for alternative treatments. The decision to try the vagal nerve stimulation in patients with bulimia nervosa is based on our belief that the activity in the gastric vagus nerves might be altered in bulimia nervosa. We have tested this hypothesis by using a drug, ondansetron, which stabilized the activity in the vagus nerve. In women receiving ondansetron under controlled experimental conditions, a rapid and significant reduction in binge eating and vomitng was found. While these results supported our basic hypothesis of vagal involvement in driving binge/vomit episodes, individual responses seemed related to the severity of the illness. That is, the women in this study who had severe intractable bulmina experienced a reduction in the frequency of bulimia episodes; however, they did not uniformly achieve complete abstinence. Since ondansetron only acts on a subset of vagal nerves, the above results suggests that a complete response may be achieved in severely ill patients if a greater proportion of the vagal nerves are modulated. Electrical stimulation of the vagus nerve by implantation of the NeuroCybernetic Prosthesis (NCP) System represents one way of affecting a larger number of nerves that can be accomplished through drug treatment.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 神经性贪食症是一种严重的精神疾病，几乎只发生在女性中，据报道终生患病率为 1%-4%。 这种疾病最常见的形式是暴饮暴食，然后进行催吐，通常表现为自我催吐，并伴有对行为的失控。 治疗通常包括认知、行为治疗或抗抑郁药物的使用。 由于这些治疗方法仅具有一定效果，尤其是对于病情严重的患者，因此需要替代治疗方法。 我们决定对神经性贪食症患者尝试迷走神经刺激，因为我们相信胃迷走神经的活动可能会在神经性贪食症中发生改变。我们使用昂丹司琼药物验证了这一假设，该药物可以稳定迷走神经的活动。 在受控实验条件下接受昂丹司琼治疗的女性中，暴食和呕吐现象迅速而显着减少。 虽然这些结果支持了我们的基本假设，即迷走神经参与驱动暴饮暴食/呕吐事件，但个体反应似乎与疾病的严重程度有关。也就是说，本研究中患有严重顽固性贪食症的女性暴食症发作的频率有所减少；然而，他们并没有一致实现完全禁欲。由于昂丹司琼仅作用于一部分迷走神经，上述结果表明，如果调节更大比例的迷走神经，则可以在重症患者中实现完全缓解。通过植入神经控制假体（NCP）系统对迷走神经进行电刺激是影响大量神经的一种方法，可以通过药物治疗来实现。