IMPLANTED VAGUS NERVE STIMULATORS FOR SEVERE BULIMIA

植入迷走神经刺激器治疗严重贪食症

• 批准号: 7375950
• 负责人: PATRICIA L FARIS
• 金额: $ 2.58万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375950
• 关键词: IMPLANTED; VAGUS; NERVE; STIMULATORS; SEVERE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bulimia nervosa is a serious psychiatric disease that occurs almost exclusively in women with a reported lifetime prevalence ranging from 1%-4%. The most common form of the illness is characterized by binge-eating followed by purging, usually in the form of self-induced vomiting with an accompanying loss of control over the behaviors. Treament usually consists of cognitive, behavioral therapy or antidepressent use. Because these treatments are only somewhat effective, especially for severely ill patients, there is a need for alternative treatments. The decision to try the vagal nerve stimulation in patients with bulimia nervosa is based on our belief that the activity in the gastric vagus nerves might be altered in bulimia nervosa. We have tested this hypothesis by using a drug, ondansetron, which stabilized the activity in the vagus nerve. In women receiving ondansetron under controlled experimental conditions, a rapid and significant reduction in binge eating and vomitng was found. While these results supported our basic hypothesis of vagal involvement in driving binge/vomit episodes, individual responses seemed related to the severity of the illness. That is, the women in this study who had severe intractable bulmina experienced a reduction in the frequency of bulimia episodes; however, they did not uniformly achieve complete abstinence. Since ondansetron only acts on a subset of vagal nerves, the above results suggests that a complete response may be achieved in severely ill patients if a greater proportion of the vagal nerves are modulated. Electrical stimulation of the vagus nerve by implantation of the NeuroCybernetic Prosthesis (NCP) System represents one way of affecting a larger number of nerves that can be accomplished through drug treatment.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。神经性贪食症是一种严重的精神病，几乎完全发生在据报道的终生患病率从1％-4％的女性中发生。该疾病的最常见形式的特征是暴饮暴食，然后是清除，通常以自我诱发的呕吐形式，随附对行为的控制丧失。疾病通常由认知，行为疗法或抗抑郁药组成。由于这些治疗仅有效，尤其是对于严重患者，因此需要替代治疗。在神经性贪食症患者中尝试迷走神经刺激的决定是基于我们相信神经性贪食症神经可能会改变胃迷走神经的活性。我们通过使用药物Ondansetron检验了这一假设，该假设稳定了迷走神经的活性。在受控的实验条件下接受ondansetron的妇女中，发现暴饮暴食和呕吐的迅速而显着减少。尽管这些结果支持了我们在驱动暴饮暴食/呕吐发作中迷走神经参与的基本假设，但单个反应似乎与疾病的严重程度有关。也就是说，这项研究中严重顽固性bulmina的妇女经历了贪食症发作频率的降低。但是，他们并没有统一实现完全的戒酒。由于Ondansetron仅作用于迷走神经的一部分，因此上述结果表明，如果调制了更大比例的迷走神经，则严重患者可能会达到完全反应。通过植入神经结构假体（NCP）系统对迷走神经的电刺激是影响可以通过药物治疗来实现的大量神经的一种方法。