HCV-HIV COINFECTION: IMPACT OF IMMUNE DYSFUNCTION

HCV-HIV 混合感染：免疫功能障碍的影响

• 批准号: 7605012
• 负责人: RICHARD K. STERLING
• 金额: $ 17.6万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-20 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605012
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Condition; Disease; Funding; Grant; HIV; Hepatitis C virus; Histologic; Immune System Diseases; Immunocompetence; Individual; Institution; Liver Fibrosis; Natural History; Patients; Rate; Reporting; Research; Research Personnel; Resources; Severities; Source; United States National Institutes of Health; Virus Diseases; anti-hepatitis C; improved; response; Computer Retrieval of Information on Scientific Projects Database; Condition; Disease; Funding; Grant; HIV; Hepatitis C virus; Histologic; Immune System Diseases; Immunocompetence; Individual; Institution; Liver Fibrosis; Natural History; Patients; Rate; Reporting; Research; Research Personnel; Resources; Severities; Source; United States National Institutes of Health; Virus Diseases; anti-hepatitis C; improved; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Effective therapy for human immunodeficiency virus (HIV) infection has markedly prolonged survival in infected individuals. As a result, other comorbid conditions in these patients are becoming more clinically important. Approximately 30% of HIV infected patients are also infected with hepatitis C virus (HCV) which is now the leading co-morbid disease in HIV-infected individuals. The histologic severity and natural history of HCV is reported to be accelerated in those co-infected with HIV. Although treatment of HCV has improved, the response rates in coinfected individuals remains suboptimal. It is hypothesized that: 1) the severity and progression of hepatic fibrosis in patients with HIV-HCV coinfection is directly related to the immunologic competence of the individual, and 2) the virologic response to anti-HCV treatment is directly related to the degree of immunologic competence.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 人类免疫缺陷病毒（HIV）感染的有效疗法在感染个体中显着延长了生存率。 结果，这些患者的其他合并状况在临床上变得越来越重要。 大约30％的艾滋病毒感染患者还感染了丙型肝炎病毒（HCV），该病毒现在是HIV感染者的主要合并症。 据报道，HCV的组织学严重程度和自然历史在与HIV共同感染的人中被加速。尽管HCV的治疗有所提高，但共同感染的个体的反应率仍然是最佳的。 假设：1）HIV-HCV共感染患者的肝纤维化的严重程度和进展与个体的免疫学能力直接相关； 2）对抗HCV治疗的病毒学反应与免疫能力直接相关。