WOMEN RESILIENCE TO TRAUMA: FMRI STUDY OF EMOTION

女性对创伤的恢复力：FMRI 情绪研究

• 批准号: 7605308
• 负责人: ANTONIA S NEW
• 金额: $ 2.19万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605308
• 关键词: Amygdaloid structure; Anger; Applications Grants; Brain; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Computers; Condition; Data; Emotional; Emotions; Face; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Image; Incentives; Institution; Life; Maintenance; Measures; Medial; Morals; Pain; Play; Pliability; Post-Traumatic Stress Disorders; Prefrontal Cortex; Psychosocial Factor; Religion; Research; Research Personnel; Resources; Rewards; Shock; Social support; Source; Spirituality; Stress; Structure; Trauma; United States National Institutes of Health; Woman; Work; blood oxygenation level dependent response; coping; design; experience; functional disability; intimate partner violence; mind control; optimism; positive emotional state; resilience; response; sexual trauma

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principal goal of this project is obtain pilot data for a grant proposal. The goal of the grant is to understand the regional brain control of emotion in women who have experienced sexual trauma or intimate partner violence. Specifically, the project will compare women who demonstrate resiliency after traumatic exposure (as evidenced by the maintenance of function in the domains of work, interpersonal relationships and enjoyment of life) to those who show functional impairment and develop PTSD. fMRI BOLD response will be used to explore whether resilience to the negative consequences of extreme stress will be related to reduced amygdala and enhanced medial prefrontal cortex function in response to fMRI imaging tasks designed to evaluate these brain structures. We propose to use four tasks during fMRI. 1) A cognitive reappraisal task has been shown to activate the prefrontal cortex. In this task, subjects are asked to view pictures designed to elicit emotionally neutral, negative and positive responses. They will also be asked to enhance and suppress those emotions while in the magnet. 2) We will also be using a task exposing subjects to different intensities of emotional faces, showing them fearful, angry and neutral faces. This task has been shown to activate the amygdala. 3) We will employ a reward incentive task in which subject play a computer game under different conditions with the potential to win or lose small amounts of money. 4) Lastly, they will be studied with fMRI during a task in which they will be told that they will be given an uncomfortable but not extremely painful electric shock, while viewing specific images, while under other conditions they will be "safe'. In actuality, no shock will be delivered. Finally we will explore psychosocial factors associated with functional resilience in the domains of positive emotions/optimism, Cognitive flexibility (including the capacity for positive reappraisal), moral compass (including measures of spirituality and attachment to religion), social support and active coping.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的主要目标是获取赠款提案的试点数据。该拨款的目的是了解经历过性创伤或亲密伴侣暴力的女性大脑对情绪的控制区域。具体来说，该项目将比较那些在遭受创伤后表现出复原力的女性（通过工作、人际关系和享受生活领域的功能维持）与那些表现出功能障碍并患上创伤后应激障碍（PTSD）的女性。 fMRI BOLD 响应将用于探索对极端压力负面后果的恢复能力是否与杏仁核减少和内侧前额叶皮层功能增强有关，以响应旨在评估这些大脑结构的 fMRI 成像任务。我们建议在功能磁共振成像期间使用四个任务。 1）认知重新评估任务已被证明可以激活前额叶皮层。在这项任务中，受试者被要求观看旨在引发情绪中立、消极和积极反应的图片。他们还将被要求在磁铁中增强和抑制这些情绪。 2）我们还将使用一项任务，让受试者接触不同强度的情绪面孔，向他们展示恐惧、愤怒和中性的面孔。该任务已被证明可以激活杏仁核。 3）我们将采用奖励激励任务，其中受试者在不同条件下玩电脑游戏，有可能赢得或失去少量金钱。 4) 最后，他们将在一项任务中接受功能磁共振成像研究，其中他们将被告知，在观看特定图像时，他们将受到不舒服但不是极其痛苦的电击，而在其他条件下，他们将是“安全的”。最后，我们将探讨与积极情绪/乐观、认知灵活性（包括积极重新评价的能力）、道德指南针（包括灵性和宗教依恋的衡量标准）等领域的功能恢复力相关的心理社会因素。 ， 社会的支持和积极应对。