2020 Signal Transduction in Microorganisms Gordon Research Conference and Gordon Research Seminar

2020微生物信号转导戈登研究会议暨戈登研究研讨会

基本信息

批准号：
9902685
负责人：
Sean Crosson
金额：
$ 0.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-02 至 2020-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9902685
关键词：
Address Allergic Disease Antimicrobial Resistance Applied Research Area Bacteria Basic Science Behavior Biochemistry Biology Biophysics Cell physiology Cells Cellular biology Chemicals Chemoreceptors Collaborations Communicable Diseases Communities Cryo-electron tomography Cyclic Nucleotides Data Development Discipline Disease Environment Event Flagella Fostering Goals Human Image Immune System Diseases Immune response Immune system Invaded Life Style Link Locomotion Macromolecular Complexes Mentors Mentorship Methodology Methods Microbial Biofilms Microbiology Microfluidics Mission Modeling Molecular Molecular Genetics National Institute of Allergy and Infectious Disease Nucleotides Participant Pathogenesis Pathway interactions Postdoctoral Fellow Process Property Research Research Personnel Resolution Respiratory System Role Scientist Second Messenger Systems Sensory Signal Transduction Specialist Structure Students System Systems Biology Techniques Time Tissues Training United States National Institutes of Health Virulence Virulence Factors Work antimicrobial bacterial genetics cell motility combat design educational atmosphere experience experimental study fighting frontier graduate student host-microbe interactions interdisciplinary collaboration interest macromolecular assembly meetings microbial microorganism novel pathogen pathogenic bacteria posters prevent programs quorum sensing skills small molecule success supportive environment symposium

项目摘要

Project summary The 2020 Gordon Research Conference on Sensory Transduction in Microorganisms to be held in Ventura, CA will explore recent advances in understanding signal transduction in bacteria, especially pathogens. Focus will be placed on chemosensory and quorum sensing mechanisms and pathways, small molecule intracellular signals (e.g. c-di-GMP and other cyclic nucleotides, ppGpp), two component systems and the cellular processes they regulate as well as mechanisms of bacterial lifestyle decisions including biofilms, bacterial multicellular behavior and predator-prey interactions. The roles of these systems with respect to pathogenesis and antimicrobial resistance will be central themes. A newly designed topic for this conference will be host- microbe interactions including the interplay between bacterial second messengers and the host immune system. All these critical areas will be addressed through cutting-edge applications of molecular genetics, cell biology, biochemistry, and chemical biology as well as structural, imaging, biophysical, and computational approaches. Data from high-resolution experiments will be paired with modeling to understand and predict the behavior of complex macromolecular assemblies and signaling circuitry. Invited speakers will include both established and early-stage investigators. In addition, poster presenters will compete for short talks. Participants will benefit from the Conference's open, collegial atmosphere that provides unique opportunities to engage in scientific discussion, promote scientific rigor, and foster interdisciplinary collaboration. For the third time, a Gordon Research Seminar (GRS) for postdocs and graduate students will precede the GRC. The GRS provides a supportive environment for young scientists to present their work and receive advice by leaders in the field. The STIM community has long supported junior scientists, and we view the success of the GRS as a necessity to continue on this mission. The GRS will help us not only nurture the development of early stage investigators, but also promote diversity within our community. The GRS will help junior scientists gain the confidence and skills to become full-fledged GRC participants. The well-integrated STIM GRC/GRS will direct established investigators to the most important questions confronting our field and will encourage young scientists to apply their recent training to the exciting new areas of microbiology.

项目概要 2020 年戈登微生物感觉转导研究会议将于加利福尼亚州文图拉举行将探讨了解细菌（尤其是病原体）信号转导的最新进展。焦点将置于化学感应和群体感应机制和途径、小分子细胞内信号（例如 c-di-GMP 和其他环核苷酸，ppGpp）、双组分系统和细胞它们调节的过程以及细菌生活方式决定的机制，包括生物膜、细菌多细胞行为和捕食者-猎物相互作用。这些系统在发病机制中的作用抗菌素耐药性将成为中心主题。本次会议将主办一个全新设计的主题—— 微生物相互作用，包括细菌第二信使与宿主免疫之间的相互作用系统。所有这些关键领域都将通过分子遗传学、细胞遗传学的前沿应用来解决。生物学、生物化学和化学生物学以及结构、成像、生物物理和计算接近。来自高分辨率实验的数据将与建模相结合，以理解和预测复杂大分子组装体和信号电路的行为。受邀演讲者将包括已建立的和早期的研究人员。此外，海报展示者还将进行简短的演讲比赛。与会者将受益于会议开放的学院氛围，这提供了独特的机会参与科学讨论，促进科学严谨性，并促进跨学科合作。对于第三个届时，戈登研究研讨会（GRS）将在 GRC 之前为博士后和研究生举办。 GRS 为年轻科学家提供一个支持性的环境来展示他们的工作并接受领导者的建议领域。 STIM 社区长期以来一直支持初级科学家，我们将 GRS 的成功视为继续履行这一使命的必要性。 GRS不仅能帮助我们培育早期发展调查员，同时也促进我们社区内的多样性。 GRS 将帮助初级科学家获得成为成熟的 GRC 参与者的信心和技能。集成良好的 STIM GRC/GRS 将指导建立研究人员来解决我们领域面临的最重要问题，并将鼓励年轻人科学家们将他们最近的培训应用到令人兴奋的微生物学新领域。