2022 Sensory Transduction in Microorganisms GRC & GRS

2022年微生物感觉转导GRC

• 批准号: 10374971
• 负责人: Karen M Ottemann
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10374971
• 关键词: Address; Allergic Disease; Antibiotics; Antimicrobial Resistance; Applied Research; Area; Bacteria; Bacteriophages; Basic Science; Behavior; Biochemistry; Biology; Biophysics; Cell physiology; Cells; Cellular biology; Chemicals; Collaborations; Communicable Diseases; Communities; Cryo-electron tomography; Data; Development; Disease; Eating; Environment; Event; Fostering; Goals; Health; Human; Image; Immune System Diseases; Immune system; Institutes; Invaded; Knowledge; Life Style; Macromolecular Complexes; Mammals; Methods; Microbial Biofilms; Microbiology; Microfluidics; Mission; Modeling; Molecular; Molecular Genetics; National Institute of Allergy and Infectious Disease; Output; Participant; Pathogenesis; Pathway interactions; Persons; Plants; Postdoctoral Fellow; Process; Property; Research; Research Personnel; Resolution; Role; Science; Scientist; Sensory; Signal Transduction; Specialist; Structure; System; Systems Biology; Techniques; Time; Tissues; Training; Transcriptional Regulation; Underrepresented Populations; United States National Institutes of Health; Virulence; Virulence Factors; Work; antimicrobial; bacterial genetics; base; career; cell motility; combat; design; educational atmosphere; experimental study; fighting; graduate student; host colonization; host-microbe interactions; innovation; interdisciplinary collaboration; interest; macromolecular assembly; mechanotransduction; meetings; microbial; microbial community; microbiome; microbiota; microorganism; pathogen; pathogenic bacteria; posters; prevent; programs; receptor; response; skills; small molecule; success; supportive environment; symposium; synthetic biology

Project summary The 2022 Gordon Research Conference on Sensory Transduction in Microorganisms to be held in Ventura CA in January 2022 will explore recent advances in understanding signal transduction in bacteria, especially pathogens. Focus will be placed on chemosensory mechanisms and pathways, small molecule intracellular signals (e.g. c-di-GMP), two component systems and the cellular processes they regulate as well as mechanisms of bacterial lifestyle decisions including biofilms, bacterial multicellular behavior and predator-prey interactions. The roles of these systems with respect to pathogenesis, antimicrobial resistance, and synthetic biology will be central themes. An important topic for this conference will be host-microbe interactions. All these critical areas will be addressed through cutting-edge applications of molecular genetics, cell biology, biochemistry, and chemical biology as well as structural, imaging, biophysical, and computational approaches. Data from high-resolution experiments will be paired with modeling to understand and predict the behavior of complex macromolecular assemblies and signaling circuitry. Invited speakers will include both established and early-stage investigators using a wide array of approaches. In addition, short talks will be chosen from the abstracts to give additional early-career scientists a chance to speak, and to round on the program. Participants will benefit from the Conference's open, collegial atmosphere that provides multiple opportunities to engage in scientific discussion, promote scientific rigor, and foster interdisciplinary collaboration. New, innovative efforts will be used to increase participation of scientists from historically under-represented backgrounds, and multiple efforts will be taken to make participants feel welcome and valued. For the fifth time, a Gordon Research Seminar (GRS) for postdocs and graduate students will precede the GRC. The GRS provides a supportive environment for young scientists to present their work, make connections, and receive advice by leaders in the field. The STIM community has long supported junior scientists, and we view the success of the GRS as a necessity to continue on this mission. The GRS will help us not only nurture the development of early stage investigators, but also promote diversity within our community. The GRS will help junior scientists gain the confidence and skills to become full-fledged GRC participants. The well-integrated STIM GRC/GRS will direct established investigators to the most important questions confronting our field and will encourage young scientists to apply their recent training to the exciting new areas of microbiology.

项目概要 2022 年戈登微生物感觉转导研究会议将于加利福尼亚州文图拉举行 2022 年 1 月将探讨了解细菌信号转导的最新进展，特别是 病原体。重点将放在化学感应机制和途径、小分子细胞内 信号（例如 c-di-GMP）、两个组成系统及其调节的细胞过程 细菌生活方式决定的机制，包括生物膜、细菌多细胞行为和捕食者-猎物 互动。这些系统在发病机制、抗菌素耐药性和合成方面的作用 生物学将是中心主题。本次会议的一个重要主题是宿主与微生物的相互作用。所有这些 关键领域将通过分子遗传学、细胞生物学、 生物化学、化学生物学以及结构、成像、生物物理和计算方法。 来自高分辨率实验的数据将与建模相结合，以理解和预测 复杂的大分子组装体和信号电路。受邀演讲者将包括知名人士和 早期研究人员使用多种方法。此外，简短的演讲将从 摘要为更多处于职业生涯早期的科学家提供了发言的机会，并围绕该计划进行讨论。 与会者将受益于会议开放的学院氛围，提供多种机会 参与科学讨论，促进科学严谨性，并促进跨学科合作。新的， 将利用创新努力来增加历史上代表性不足的科学家的参与 我们将采取多种努力让参与者感到受欢迎和受到重视。第五次， 在 GRC 之前，将为博士后和研究生举办戈登研究研讨会 (GRS)。 GRS 为年轻科学家提供一个展示他们的工作、建立联系和接收信息的支持性环境 该领域领导者的建议。 STIM 社区长期以来一直支持初级科学家，我们认为 GRS 的成功是继续履行这一使命的必要条件。 GRS 不仅会帮助我们培育 发展早期研究人员，同时也促进我们社区的多样性。 GRS 将提供帮助 初级科学家获得成为成熟的 GRC 参与者的信心和技能。综合性良好 STIM GRC/GRS 将指导已建立的研究人员解决我们领域和领域面临的最重要问题 将鼓励年轻科学家将他们最近的培训应用于令人兴奋的微生物学新领域。