EARLY TREATMENT OF ALS WITH NUTRITION AND NIPPV

ALS 的早期营养治疗和 NIPPV 治疗

• 批准号: 7605807
• 负责人: RUP TANDAN
• 金额: $ 5.19万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605807
• 关键词: Amyotrophic Lateral Sclerosis; Computer Retrieval of Information on Scientific Projects Database; Early treatment; Funding; Goals; Grant; Institution; Intervention; Measures; Methods; Modality; Nutrition management; Nutritional; Patients; Phase III Clinical Trials; Pilot Projects; Recruitment Activity; Research; Research Personnel; Resources; Respiratory Failure; Site; Source; Testing; United States National Institutes of Health; Upper arm; energy balance; improved; nutrition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a pilot study involving 11 sub-sites to test the efficacy with NIPPV and nutritional management in patients with ALS. Six sites will be involved with early NIPPV intervention, and five sites will be involved in nutritional management intervention, and each site will recruit 20 patients. The primary goals of the NIPPV study arm are to develop and validate strategies to improve tolerability of NIPPV, to identify factors that influence acceptance of this treatment modality, and to evaluate measures of early respiratory failure. The primary goals of the early nutrition management arm are to develop and validate methods to determine energy balance in ALS patients that will be applicable to a multicenter Phase III study of nutrition and NIPPV.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这是一项试点研究，涉及11个子站点，用于测试ALS患者的NIPPV和营养管理的功效。 六个站点将参与NIPPV早期干预，五个地点将参与营养管理干预措施，每个地点将招募20名患者。 NIPPV研究部门的主要目标是制定和验证提高NIPPV的耐受性的策略，以确定影响接受此治疗方式接受的因素，并评估早期呼吸衰竭的措施。早期营养管理部门的主要目标是开发和验证方法来确定ALS患者的能量平衡，这将适用于多中心III期营养和NIPPV研究。