EARLY TREATMENT OF ALS WITH NUTRITION AND NIPPV

ALS 的早期营养治疗和 NIPPV 治疗

• 批准号: 7604966
• 负责人: Mark B. Bromberg
• 金额: $ 2.19万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604966
• 关键词: Amyotrophic Lateral Sclerosis; Body Weight decreased; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Early treatment; Energy Intake; Environmental air flow; Funding; Future; Grant; Institution; Invasive; Measures; Methods; Muscle; Nutritional status; Patients; Phase III Clinical Trials; Progressive Disease; Research; Research Personnel; Resources; Source; United States National Institutes of Health; energy balance; experience; indexing; nutrition; prospective; treatment effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ALS (Lou Gehrig's Disease) is a progressive disease with no cure and minimally effect treatment. Clinical experience indicates that patients lose weight from loss of muscle mass, but also from reduced caloric intake. Hypothesis: Adequate nutrition may have a positive impact on survival. A group of measures are available as quantitative indices of global ALS progression, but similar measures have not been developed to evaluate nutritional status. Objective: Develop and validate methods from prospective data to determine energy balance that will be applicable in a future multicenter Phase III study of nutrition and non-invasive ventilation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 ALS（Lou Gehrig病）是一种进行性疾病，没有治愈和最小作用治疗。 临床经验表明，患者因肌肉质量的损失而减轻体重，但同时摄入量减少。 假设：足够的营养可能对生存产生积极影响。 一组措施可作为全球ALS进展的定量指数，但尚未开发出类似的措施来评估营养状况。目的：从前瞻性数据开发和验证方法，以确定能量平衡，这将适用于未来的多中心营养和非侵入性通气研究中。