Multimodal Functional Imaging of Auditory Perception Under General Anesthesia

全身麻醉下听觉感知的多模态功能成像

• 批准号: 7640739
• 负责人: Patrick L. Purdon
• 金额: $ 17.7万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7640739
• 关键词: Adverse effects; Anesthesia procedures; Anesthetics; Anxiety; Area; Auditory; Auditory Evoked Potentials; Auditory Perception; Auditory system; Award; Awareness; Biomedical Research; Brain; Brain region; Clinic; Clinical; Clinical Pharmacology; Clinical assessments; Conscious; Dose; Dreams; Drug Monitoring; Electroencephalogram; Event; Event-Related Potentials; Functional Imaging; Functional Magnetic Resonance Imaging; General Anesthesia; Goals; Hearing; K-Series Research Career Programs; Knowledge; Light; Measures; Mediating; Medical; Medicine; Memory; Mentors; Modern Medicine; Monitor; Morbidity - disease rate; Multimodal Imaging; NIH Program Announcements; National Institute of Neurological Disorders and Stroke; Nausea and Vomiting; Neuraxis; Neurobiology; Neurosciences; Nightmare; Operative Surgical Procedures; Parietal; Patients; Pattern; Perception; Pharmaceutical Preparations; Pharmacodynamics; Physiological; Post-Traumatic Stress Disorders; Postoperative Period; Problem Solving; Process; Process Measure; Propofol; Research; Research Personnel; Research Project Grants; Rest; Safety; Sedation procedure; Site; Sleep disturbances; Slow-Wave Sleep; Stereotyping; Stimulus; Structure; System; Training; Unconscious State; Ventilatory Depression; Work; base; career; heart rhythm; imaging modality; improved; neurophysiology; programs; response; sound

DESCRIPTION (provided by applicant): A fundamental problem in neuroscience and medicine is to understand the mechanisms of general anesthesia. This proposal, "Multimodal Functional Imaging of Auditory Perception Under General Anesthesia", is submitted in response to the NINDS program announcement for Mentored Quantitative Research Career Development Awards (K25). The candidate seeks to gain training in the neurobiology and clinical pharmacology of anesthesia in order to apply multimodal functional imaging methods to the study of the mechanisms of general anesthesia. Loss of consciousness under general anesthesia is measured clinically by observing the loss of response to external stimuli. However, auditory perception and memory are possible in patients who are clinically unconscious, which may result in post-operative recall of events during anesthesia. Consequences of post-operative recall include sleep disturbances, dreams, nightmares, flashbacks and anxiety, as well as post-traumatic stress disorder. Clinical anesthetic brain monitors are based on empirical relationships between stereotyped anesthesia-related electroencephalographic (EEG) patterns and clinical assessments of patient awareness, but cannot measure activity within functional brain regions responsible for auditory perception under anesthesia. The goal of this project is to characterize anesthesia-induced changes of function in the auditory system using simultaneous EEG and fMRI. FMRI responses to perception of sound temporal envelope will be measured at varying levels of propofol anesthesia, ranging from light sedation to deep anesthesia, with simultaneous EEG. Changes in auditory perceptual processing measured with fMRI will be related to clinical level of consciousness, propofol drug levels, and anesthesia-related EEG patterns. These studies will provide a means to quantify the amount of perceptual processing that occurs after anesthesia-induced loss of consciousness, as well as the EEG patterns that correlate with loss of perceptual processing. Through this research project, as well as didactic courses and tutorials, the candidate will be trained in the neurobiology and clinical pharmacology of anesthesia. The training provided by this Award will help the candidate achieve the long-term career goal of leading an independent biomedical research program to study the systems neuroscience of anesthesia. General anesthesia is administered to over 50,000 patients daily for medical and surgical procedures, but its basic brain mechanisms are not known. Despite safety improvements, anesthesia results in serious side effects such as cardio-respiratory depression or post-operative recall. Through these studies, we hope to begin developing the fundamental neuroscience knowledge necessary to improve anesthetic drugs and monitoring, and to one day solve the problem of anesthesia-related morbidity.

描述（由申请人提供）：神经科学和医学中的一个基本问题是了解全身麻醉的机制。该提案是“在全身麻醉下对听觉感知的多模式功能成像”，以响应NINDS计划公告，宣布指导定量研究职业发展奖（K25）。候选人试图获得麻醉神经生物学和临床药理学的培训，以便将多模式功能成像方法应用于全身麻醉机制的研究。通过观察对外部刺激的反应丧失，在临床上测量全身麻醉下意识的丧失。但是，在临床上无意识的患者中，可能会导致听觉感知和记忆力，这可能导致术后对麻醉期间事件的回忆。术后召回的后果包括睡眠障碍，梦想，噩梦，闪回和焦虑以及创伤后应激障碍。临床麻醉脑监测器是基于与患者意识的定型观念与麻醉相关的脑电图（EEG）模式和临床评估之间的经验关系，但无法衡量负责麻醉下听觉感知的功能性大脑区域的活动。该项目的目的是使用同时使用EEG和fMRI来表征听觉系统中麻醉诱导的功能变化。 fMRI对声音颞包膜感知的反应将在不同水平的丙泊酚麻醉下测量，从轻度镇静到深度麻醉，同时进行脑电图。通过fMRI测量的听觉感知处理的变化将与临床意识水平，丙泊酚药物水平和与麻醉相关的脑电图模式有关。这些研究将提供一种方法来量化麻醉引起的意识丧失以及与知觉处理丧失相关的脑电图模式。通过该研究项目以及教程和教程，候选人将接受麻醉的神经生物学和临床药理学的培训。该奖项提供的培训将有助于候选人实现长期职业目标，即领导独立的生物医学研究计划来研究麻醉的系统神经科学。每天对超过50,000名患者进行全身麻醉，以进行医疗和外科手术，但其基本的大脑机制尚不清楚。尽管有安全性的改善，但麻醉会导致严重的副作用，例如心脏呼吸抑郁症或术后召回。通过这些研究，我们希望开始发展改善麻醉药物和监测所需的基本神经科学知识，并有一天解决与麻醉相关的发病率的问题。