Training Interdisciplinary Scientists for Functional Cure of Diabetes

培训跨学科科学家进行糖尿病功能性治疗

• 批准号: 9769709
• 负责人: Jose Oberholzer
• 金额: $ 10.8万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-19 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769709
• 关键词: Affect; Applications Grants; Basic Science; Biomedical Engineering; Biomedical Research; Biotechnology; Cell Therapy; Chicago; Clinical; Clinical Engineering; Collaborations; Development Plans; Diabetes Mellitus; Disease; Engineering; Ensure; Ethnic group; Faculty; Fostering; Funding; Future Generations; Gender; Goals; Illinois; Immersion Investigative Technique; Individual; Insulin-Dependent Diabetes Mellitus; Interdisciplinary Study; Internships; Islets of Langerhans Transplantation; Knowledge; Mentors; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Office of Administrative Management; Operative Surgical Procedures; Participant; Recording of previous events; Research; Research Project Grants; Research Technics; STEM research; Scientist; Structure; Students; Techniques; Training; Training Programs; United States; Universities; base; career development; college; cost; early awareness; early satiety; experience; improved; innovation; interest; laboratory facility; lectures; multidisciplinary; novel; programs; public health relevance; recruit; summer internship; translational approach; undergraduate education; undergraduate student

 DESCRIPTION (provided by applicant): In this R25 proposal, our aim is to mentor and train future generation of interdisciplinary scientists and engineers in the field of diabetes research and treatment. Diabetes is a debilitating disease affecting 25.8 million in the United States at a cost of over $180 billion annually. In partnership with the UIC Honors College, Department of Bioengineering, and Department of Surgery, this training program is a non-academic credit, ten- week multidisciplinary summer internship program for undergraduates. The program is unique in the following: (i) well-established training lectures covering basics and advanced diabetes research topics, emerging biotechnology, clinical translational strategies, proficiency in basic science techniques and knowledge, and thoughtful career development plan; (ii) a specific research theme is integrated into the program that focuses on how to improve islet transplantation, a promising cell-based therapy for Type I diabetes with an ultimate goal to bring a functional cure for diabetes; (iii) the training is fully supported by a unique array of multidisciplinary mentors who share common research interests; (iv) the framework of the translational and clinical orientation gives participants the opportunity to solve "real-world" problems and apply novel innovations in a clinical setting; (v) a proven record of scientific contribution, strong collaborative research of mentors, and ample experience of organizing similar educational programs will allow for a more efficient and simplistic integration of the key training components and effective administrative management; and (vi) the program resonates with UIC's commitment to provide excellent education for undergraduates through department partnership, to embrace diversity at campus, and to strength research collaboration between clinical expertise and engineering expertise. UIC has consistently proven their drive and commitment to recruit and cultivate URM trainees. The participant college and departments have well-established plans and strategies to recruit qualified undergraduates for this program. The participating mentors have strong commitment and adequate laboratory facility and funding to provide participants the opportunity to obtain the highest quality of research experience. .

 描述（由申请人提供）：在本 R25 提案中，我们的目标是指导和培训糖尿病研究和治疗领域的下一代跨学科科学家和工程师。糖尿病是一种使人衰弱的疾病，影响着美国 2580 万人。该培训计划与 UIC 荣誉学院、生物工程系和外科系合作，是一项为期十周的非学术学分多学科暑期实习计划。该项目的独特之处在于：（i）完善的培训讲座，涵盖基础知识和高级糖尿病研究主题、新兴生物技术、临床转化策略、基础科学技术和知识的熟练程度以及深思熟虑的职业发展计划；该计划纳入了一个具体的研究主题，重点关注如何改善胰岛移植，这是一种有前景的 I 型糖尿病细胞疗法，最终目标是实现糖尿病的功能性治愈；(iii) 培训得到了独特的多学科导师阵容他们共享共同的研究；(iv) 转化和临床方向的框架为参与者提供了解决“现实世界”问题并在临床环境中应用新颖创新的机会；(v) 良好的科学贡献记录、强大的协作能力；导师的研究以及组织类似教育项目的样本经验将有助于更有效、更简单地整合关键培训组成部分和有效的行政管理；(vi) 该项目与 UIC 为本科生提供优质教育的承诺相呼应；伙伴关系，拥抱多样性UIC 已经证明了他们招募和培养 URM 学员的动力和承诺，并制定了完善的计划和策略来招募参与该项目的合格本科生。导师有坚定的承诺和充足的实验室设施和资金，为参与者提供获得最高质量的研究经验的机会。

项目成果

Over ten-year insulin independence following single allogeneic islet transplant without T-cell depleting antibody induction.

在不诱导 T 细胞消耗抗体的情况下进行单次同种异体胰岛移植后，可实现十年以上的胰岛素独立。

• 发表时间: 2018
• 影响因子: 2.2
• 作者: Williams, Jack;Jacus, Nicholas;Kavalackal, Kevin;Danielson, Kirstie K;Monson, Rebecca S;Wang, Yong;Oberholzer, Jose
• 通讯作者: Oberholzer, Jose