Clinical Core (MSSM)

临床核心（MSSM）

• 批准号: 9768914
• 负责人: CHRISTINA M WYATT
• 金额: $ 18.87万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9768914
• 关键词: AIDS-Associated Nephropathy; Acetylation; African American; Archives; Bioinformatics; Biological; Blood specimen; Cell Line; Chronic; Chronic Kidney Failure; Clinical; Clinical Data; Clinical Research; Consequences of HIV; Data; Development; Diabetic mouse; End stage renal failure; Enrollment; Ensure; Epidemiology; Epithelial Cells; Gene Expression; HIV; HIV Infections; Health; Histologic; Histology; Histopathology; Human; Immune response; In Vitro; Individual; Inflammatory; Injury; Kidney; Kidney Diseases; Laboratories; Laboratory Finding; Life Cycle Stages; Link; Logistics; Mitochondria; Natural History; Nephrology; Participant; Pathogenesis; Pathway interactions; Patients; Pattern; Process; Protocols documentation; Research; Research Design; Research Personnel; Research Support; Resources; Risk; Role; SIRT1 gene; Specimen; Standardization; Tissues; Transgenic Mice; Transgenic Organisms; Tubular formation; Urine; Viral; Viral reservoir; Work; antiretroviral therapy; cell immortalization; data warehouse; disorder risk; gut microbiota; high risk; host microbiome; human subject; immortalized cell; inflammatory marker; kidney biopsy; mouse model; nephrotoxicity; programs; prospective; recruit; senescence; stool sample; synergism; transcription factor

Project Summary (Core C) The objective of the Clinical Core (Core C) is to provide biologic specimens and corresponding clinical and laboratory data from well-characterized patients with HIV infection and kidney disease and from relevant controls to support the work proposed in this Program Project. The Clinical Core will provide kidney tissue, urine, blood, and stool specimens to support research into the long-term consequences of chronic HIV infection in the kidney, including the role of HIV infection in promoting kidney disease and the potential for the kidney to serve as a reservoir for the virus.

项目总结（核心C） 临床核心（核心C）的目标是提供生物样本和相应的临床和 来自特征明确的 HIV 感染和肾病患者以及相关患者的实验室数据 支持本计划项目中提议的工作的控制措施。临床核心将提供肾组织、 尿液、血液和粪便样本支持慢性艾滋病毒长期后果的研究 肾脏感染，包括 HIV 感染在促进肾脏疾病中的作用以及 肾脏作为病毒的储存库。