Kidney Disease in HIV-Hepatitis C Virus Co-Infection

HIV-丙型肝炎病毒合并感染中的肾脏疾病

• 批准号: 8111823
• 负责人: CHRISTINA M WYATT
• 金额: $ 12.95万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111823
• 关键词: Acute; Affect; Americas; Black race; Chronic Disease; Chronic Kidney Failure; Clinical; Cohort Studies; Communicable Diseases; Complication; Development; Diagnosis; Early Diagnosis; Early treatment; Epidemiology; Family; Foundations; Future; Guidelines; HIV; HIV Infections; Heart Diseases; Hepatic; Hepatitis C; Hepatitis C virus; High Prevalence; Incidence; Infection; Integration Host Factors; Kidney Diseases; Kidney Failure; Liver diseases; Minority; Monitor; Morbidity - disease rate; Pathogenesis; Patients; Population; Prevalence; Publishing; Recording of previous events; Research Personnel; Risk; Risk Factors; Screening procedure; Societies; Testing; Translational Research; Viral; Virus; Virus Diseases; antiretroviral therapy; base; cohort; high risk; kidney epithelial cell; mortality; patient population; programs; prospective

DESCRIPTION (provided by applicant): With the widespread introduction of antiretroviral therapy, HIV has become a chronic disease, and HIV- related kidney disease has emerged as an important cause of morbidity and mortality. Both HIV infection and antiretroviral therapy have been associated with kidney disease. Studies suggest that the risk of HIV-related kidney disease is increased in patients with HIV-Hepatitis C virus co-infection, but studies have not focused on the epidemiology of kidney disease in these patients. Worldwide, an estimated 40 million people are infected with HIV, and 4-5 million people are co-infected with HIV and Hepatitis C. The highest prevalence of HIV-Hepatitis C co-infection occurs in minority populations at increased risk for kidney disease. This proposal aims to investigate the epidemiology of kidney disease in patients with HIV-Hepatitis C co-infection, and to identify host and viral factors associated with increased risk. The identification of risk factors will identify patients who may benefit from enhanced screening for early detection and treatment of kidney disease. The primary objective of this application is to support the candidate's development as an independent clinical and translational investigator in the field of HIV-related kidney disease. The specific aims of this proposal are: (1) To compare the epidemiology of kidney disease in patients with HIV-Hepatitis C co-infection to that in patients with either HIV or Hepatitis C virus alone. (2) To identify host factors associated with kidney disease in patients with HIV-Hepatitis C co-infection. (3) To identify viral factors associated with kidney disease in patients with HIV-Hepatitis C co-infection. Relevance: HIV affects more than 40 million people worldwide, and kidney disease is an important complication in patients being treated for HIV. Minority patients with both HIV and Hepatitis C virus infection may be at particularly high risk for kidney disease. This study will help to identify HIV-infected patients who may be at risk for kidney disease, in order to diagnose and treat kidney disease before the development of kidney failure and other serious complications.

描述（由申请人提供）： 随着抗逆转录病毒治疗的广泛采用，艾滋病毒已成为一种慢性疾病，与艾滋病毒相关的肾病已成为发病和死亡的重要原因。 HIV 感染和抗逆转录病毒治疗都与肾脏疾病有关。研究表明，HIV-丙型肝炎病毒合并感染的患者患 HIV 相关肾脏疾病的风险增加，但研究并未关注这些患者肾脏疾病的流行病学。在全世界范围内，估计有 4000 万人感染艾滋病毒，并且有 4-500 万人同时感染艾滋病毒和丙型肝炎。艾滋病毒和丙型肝炎双重感染的最高患病率发生在肾病风险较高的少数群体中。该提案旨在调查艾滋病毒-丙型肝炎双重感染患者的肾脏疾病流行病学，并确定与风险增加相关的宿主和病毒因素。风险因素的识别将确定哪些患者可能受益于加强筛查以早期发现和治疗肾脏疾病。该申请的主要目标是支持候选人发展成为 HIV 相关肾脏疾病领域的独立临床和转化研究者。 该提案的具体目标是： (1) 比较 HIV-丙型肝炎合并感染患者与单独感染 HIV 或丙型肝炎病毒患者的肾脏疾病流行病学。 (2) 确定与HIV-丙型肝炎合并感染患者肾脏疾病相关的宿主因素。 (3) 确定与 HIV-丙型肝炎合并感染患者肾脏疾病相关的病毒因素。 相关性：艾滋病毒影响着全世界超过 4000 万人，而肾脏疾病是接受艾滋病毒治疗的患者的一个重要并发症。同时感染艾滋病毒和丙型肝炎病毒的少数患者患肾脏疾病的风险可能特别高。这项研究将有助于识别可能有肾病风险的艾滋病毒感染者，以便在肾衰竭和其他严重并发症发生之前诊断和治疗肾病。

项目成果

Hepatitis C and the risk of kidney disease and mortality in veterans with HIV.

丙型肝炎以及感染艾滋病毒的退伍军人的肾脏疾病和死亡风险。

• 发表时间: 2010-02
• 作者: Fischer, Michael J;Wyatt, Christina M;Gordon, Kirsha;Gibert, Cynthia L;Brown, Sheldon T;Rimland, David;Rodriguez;Justice, Amy C;Parikh, Chirag R;VACS Project Team
• 通讯作者: VACS Project Team

Kidney disease in HIV infection: introduction.

HIV 感染中的肾脏疾病：简介。

• 发表时间: 2008-11
• 影响因子: 3.3
• 作者: Wyatt, Christina M;Klotman, Paul E
• 通讯作者: Klotman, Paul E

Estimating kidney function in HIV-infected adults in Kenya: comparison to a direct measure of glomerular filtration rate by iohexol clearance.

评估肯尼亚艾滋病毒感染成人的肾功能：与碘海醇清除率直接测量肾小球滤过率的比较。

• 发表时间: 2013
• 影响因子: 3.7
• 作者: Wyatt, Christina M;Schwartz, George J;Owino Ong'or, Willis;Abuya, Joseph;Abraham, Alison G;Mboku, Charles;M'mene, Loice B;Koima, Winnie J;Hotta, Mathew;Maier, Paula;Klotman, Paul E;Wools
• 通讯作者: Wools

Acute kidney injury in HIV-infected patients.

HIV感染者的急性肾损伤。

• 发表时间: 2008-11
• 影响因子: 3.3
• 作者: Kalim, Sahir;Szczech, Lynda A.;Wyatt, Christina M.
• 通讯作者: Wyatt, Christina M.