2/2 NCCU-LCCC Partnership in Cancer Research

2/2 NCCU-LCCC 癌症研究合作伙伴关系

• 批准号: 9769511
• 负责人: H. Shelton Earp
• 金额: $ 94.38万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-28 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769511
• 关键词: Address; Advanced Malignant Neoplasm; Advisory Committees; African American; American Cancer Society; Attention; Biotechnology; Cancer Biology; Cancer Burden; Cancer Research Project; Clinical; Collaborations; Community Outreach; Complex; Comprehensive Cancer Center; Disease; Education; Education and Outreach; Educational process of instructing; Effectiveness; Environmental Exposure; Eye; Faculty; Foundations; Funding; Genetic; Genomics; Goals; Grant; Health Promotion; Health Sciences; Health Services Accessibility; Histopathology; Human; Incidence; Infrastructure; Institution; Intervention; Leadership; Malignant Neoplasms; Mentorship; Minority; Minority Recruitment; Molecular; Morbidity - disease rate; National Cancer Institute; North Carolina; Outreach Research; Pathway interactions; Pilot Projects; Population; Population Sciences; Positioning Attribute; Predisposition; Public Health; Recurrence; Research; Research Infrastructure; Research Institute; Research Personnel; Research Training; Resources; Scientist; Socioeconomic Factors; Students; Tissues; Training; Treatment Failure; U-Series Cooperative Agreements; UNC Lineberger Comprehensive Cancer Center; Underrepresented Students; Universities; anticancer research; base; cancer education; cancer health disparity; cancer therapy; career; caucasian American; cohort; community intervention; education research; experience; graduate student; health disparity; health equity; interest; member; minority communities; minority health; minority student; minority undergraduate; mortality; outreach; population based; programs; public health relevance; recruit; senior faculty; theories; training opportunity; translational cancer research; translational scientist; undergraduate student

DESCRIPTION (provided by applicant) Abstract: The North Carolina Central University (NCCU) and the Lineberger Comprehensive Cancer Center (LCCC) at the University of North Carolina Chapel Hill (UNC-CH) will continue their effective and mutually beneficial partnership focusing on African-American health disparities. During the past 13 years NCI funding has firmly established the Partnership building on complementary institutional strengths, conducting molecular and population-based cancer research and training of junior faculty and students. This Comprehensive Partnership to Advance Cancer Health Equity (CPACHE) application builds upon the foundation already established through the previous U54 funding to meet the challenge of disparities in cancer incidence and mortality in North Carolina and the US through cancer research, education and community outreach. Our goals are to: (1) strengthen cancer research capacity at NCCU providing NCCU scientists mentorship and collaborative opportunities to compete for NCI grants; (2) enrich the capacity of NCCU and LCCC to further explore mechanisms underlying the disproportionate incidence of cancer mortality and morbidity between African Americans and Caucasian Americans, using both molecular and population-based approaches; (3) increase the number of NCCU scientists focused on cancer research as well as the education of minority undergraduate and graduate students in cancer research; (4) increase the faculty at the UNC LCCC focused on minority disparities research; and (5) create long-term collaborations between basic, public health, and translational scientists from NCCU and UNC LCCC. The strengths of each institution are uniquely positioned to overcome the weaknesses found in the other to achieve these priorities. Specific collaborative components of the proposal include: Two full and one pilot projects in community intervention and population science, one full and one pilot project in basic/translational cancer research in diseases with a higher incidence in African Americans, and 3 cores: Outreach, Research Education, and Histopathology. The partnership combines the expertise and resources of LCCC in population/public health sciences emphasizing disparities in North Carolina, genomics, cancer biology and cancer education and NCCU's demonstrated interest and faculty with minority health disparities research particularly in Durham NC, the state-funded NCCU units that allow faculty release from teaching and the emphasis on reaching minority populations and developing the careers of, faculty and students. These complementary institutional strengths will assure that the Partnership builds the infrastructure necessary for a lasting collaborative research, effective community outreach and a substantial contribution to our understanding of minority disparities.

描述（由申请人提供） 摘要：北卡罗莱纳中央大学 (NCCU) 和北卡罗莱纳大学教堂山分校 (UNC-CH) 的 Lineberger 综合癌症中心 (LCCC) 将继续开展有效和互利的合作伙伴关系，重点关注非洲-美国的健康差距。在过去的 13 年里，NCI 的资助牢固地建立了合作伙伴关系，建立在互补的机构优势、开展分子和人群癌症研究以及对初级教师和学生的培训的基础上。这一促进癌症健康公平的全面合作伙伴关系 (CPACHE) 申请建立在之前 U54 资助所建立的基础上，旨在通过癌症研究、教育和社区外展应对北卡罗来纳州和美国癌症发病率和死亡率差异的挑战。我们的目标是：(1) 加强 NCCU 的癌症研究能力，为 NCCU 科学家提供指导和合作机会，以竞争 NCI 资助； (2) 增强 NCCU 和 LCCC 的能力，利用分子和基于人口的方法，进一步探索非洲裔美国人和白人美国人之间癌症死亡率和发病率不成比例的机制； （3）增加国立政治大学专注于癌症研究的科学家数量以及少数民族本科生和研究生癌症研究的教育； (4) 增加北卡罗来纳大学 LCCC 专注于少数群体差异研究的师资队伍； (5) 在 NCCU 和 UNC LCCC 的基础科学家、公共卫生科学家和转化科学家之间建立长期合作。每个机构都具有独特的优势，能够克服对方的弱点，从而实现这些优先事项。该提案的具体合作组成部分包括：社区干预和人口科学方面的两个完整项目和一个试点项目，非裔美国人发病率较高疾病的基础/转化癌症研究的一个完整项目和一个试点项目，以及 3 个核心项目：外展、研究教育和组织病理学。该合作伙伴关系结合了 LCCC 在人口/公共卫生科学方面的专业知识和资源，强调北卡罗来纳州的差异、基因组学、癌症生物学和癌症教育，以及 NCCU 对少数族裔健康差异研究特别是在北卡罗来纳州达勒姆（NCCU 的国家资助单位）表现出的兴趣和教职人员这使得教师能够从教学中解放出来，并重点关注少数族裔群体和发展教师和学生的职业生涯。这些互补的机构优势将确保该伙伴关系建立必要的基础设施，以进行持久的合作研究、有效的社区外展以及对我们对少数族裔差异的理解做出重大贡献。