Cerebrovascular Contributions to Brain Aging and Dementia

脑血管对大脑衰老和痴呆的影响

• 批准号: 7503987
• 负责人: DAVID H SALAT
• 金额: $ 42.92万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-29 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7503987
• 关键词: Adult; Affect; Alzheimer' s Disease; American; Atrophic; Attenuated; Autopsy; Blood Vessels; Brain; Cause of Death; Cerebrovascular Disorders; Clinical; Clinical Trials; Clinical assessments; Cognition; Cognitive; Complex; Condition; Data; Dementia; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Elderly; Episodic memory; Evaluation; Event; Goals; Gray unit of radiation dose; Health; Image; Impaired cognition; Individual; Inferior; Intervention; Knowledge; Lifestyle Therapy; Magnetic Resonance Imaging; Masks; Measures; Medial; Memory; Methods; Modeling; Modification; Monitor; Nerve Degeneration; Participant; Pathology; Patients; Performance; Physiological; Procedures; Process; Rate; Research Personnel; Risk; Short-Term Memory; Stroke; Survival Analysis; Syndrome; Testing; Therapeutic; Therapeutic Intervention; Thick; Time; Tissues; Work; age related; aging brain; cerebral atrophy; cerebrovascular; cognitive control; diffusion anisotropy; disorder risk; executive function; follow-up; frontal lobe; gray matter; indexing; long term memory; mild neurocognitive impairment; neuroimaging; novel; programs; relating to nervous system; white matter

DESCRIPTION (provided by applicant): Cerebrovascular contributions to brain aging and dementia. Cerebrovascular disease (CVD) contributes in a complex manner to a host of detrimental age-related conditions including cognitive decline, neurodegeneration, and the clinical syndrome of Alzheimer's disease (AD). Still, little is known about how CVD affects the brain and cognition in these conditions. The goal of this proposal is to define the cognitive and neural consequences of CVD, and how CVD-related changes alter the course of clinical decline in AD through the use of a host of novel, advanced neuroimaging procedures. Aim 1. To identify the contribution of CVD to brain gray (GM) and white matter (WM) degeneration in older adults and in patients with AD. Hypothesis 1. Poor Cerebrovascular health contributes to GM and WM degeneration in the frontal lobe. High stroke risk at baseline predicts subsequent tissue degeneration at follow up assessment. Aim 2. To determine how CVD associated brain changes contribute to cognitive decline. Hypothesis 2. A relation exists between CVD and cognitive decline with strong associations between stroke risk and working memory, as opposed to long term memory. Aim 3. To understand how CVD contributes to clinical status, brain aging, and the progression to AD. Hypothesis 3. CVD is related to changes in cognition across time with most pronounced relations between stroke risk and reduced working, as opposed to long term, memory abilities. CVD related WM degeneration is a risk for the development of dementia. CVD risk will be characterized using the Framingham Stroke Risk profile which integrates clinical and quantitative physiological data. We will model the association between CVD measures and MRI measures of with a focus on how stroke risk predicts subsequent neural degeneration and clinical decline. Measures of CVD will be related to change in cognitive abilities and imaging measures across testing sessions separated by two and four years to determine whether CVD or associated brain changes affect the rate of the conversion from mild cognitive impairment to dementia. Knowledge from the proposed studies would be useful in the differential therapeutic intervention of AD and CVD related brain degeneration.

描述（由申请人提供）：脑血管对大脑衰老和痴呆症的贡献。脑血管疾病（CVD）以复杂的方式为许多有害年龄相关的疾病做出了贡献，包括认知能力下降，神经变性和阿尔茨海默氏病（AD）的临床综合征。尽管如此，在这些条件下CVD如何影响大脑和认知，知之甚少。该提案的目的是定义CVD的认知和神经后果，以及与CVD相关的变化如何通过使用许多新型的高级神经影像学程序来改变AD临床下降的过程。目的1。确定老年人和AD患者中CVD对脑灰（GM）和白质（WM）变性的贡献。假设1。脑血管健康不良有助于额叶的通用汽车和WM变性。基线时，高中风风险预测随后的随访评估时随后的组织变性。目标2。确定CVD相关的大脑变化如何导致认知能力下降。假设2。与长期记忆相比，CVD和认知能力下降与中风风险与工作记忆之间的牢固关联之间存在关系。目的3。了解CVD如何促进临床状况，大脑衰老和AD的发展。假设3。CVD与跨时间的认知变化有关，与长期记忆能力相比，中风风险和减少工作之间的关系最明显。与CVD相关的WM变性是痴呆发展的风险。 CVD风险将使用Framingham Stroke风险概况进行表征，该风险概况整合了临床和定量生理数据。我们将对CVD度量和MRI度量之间的关联进行建模，重点是中风风险如何预测随后的神经变性和临床下降。 CVD的措施将与两年和四年分隔的测试课程的认知能力和成像措施的变化有关，以确定CVD或相关的大脑变化是否会影响从轻度认知障碍到痴呆症的转化率。拟议研究的知识将有助于与AD和CVD相关的脑变性的差异治疗干预措施。