Rio Grande Valley Alzheimer's Resource Center for Minority Aging Research: Partnerships for Progress

里奥格兰德河谷阿尔茨海默病少数族裔老龄化研究资源中心：合作促进进步

• 批准号: 9768305
• 负责人: Gladys E. Maestre
• 金额: $ 65.47万
• 依托单位: UNIVERSITY OF TEXAS RIO GRANDE VALLEY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768305
• 关键词: Achievement; Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Behavior; Behavioral; Behavioral Research; Biomedical Research; Cardiovascular Diseases; Cardiovascular system; Cognitive; Communities; Complex; Data Collection; Development; Diabetes Mellitus; Diagnosis; Discipline; Discrimination; Disease; Economic Burden; Educational Background; Elderly; Ethnic group; Exhibits; Exposure to; Faculty; Family; Fostering; Funding; Genetic; Goals; Growth; Health; Health Personnel; Health Promotion; Healthcare; Healthcare Systems; High Prevalence; Hispanic-serving Institution; Hispanics; Individual; Infrastructure; Institutes; Institution; Intervention; Kansas; Knowledge; Latino; Lead; Leadership; Life Style; Measurement; Mentors; Mentorship; Mexico; Minority; Minority-Serving Institution; Modeling; Neighborhood Health Center; Neuropsychology; Neurosciences; Obesity; Pathway interactions; Personal Satisfaction; Pilot Projects; Population; Positioning Attribute; Poverty; Prevention; Public Health; Research; Research Personnel; Research Training; Resources; Risk; Risk Factors; Social Change; Source; South Texas; Statistical Data Interpretation; Testing; Texas; Textiles; Time; Training; Training Programs; Training and Education; Underrepresented Groups; Universities; Vision; Washington; career; career development; cohort; community organizations; early life adversity; education research; educational atmosphere; evidence base; experience; health disparity; health economics; improved; innovation; minority health; multidisciplinary; neuroimaging; programs; racial and ethnic; recruit; social; sociodemographics; socioeconomics; trait; working group

Summary OVERALL Alzheimer´s disease (AD) is an aging-associated disorder that disproportionately impacts Hispanics/Latinos, who exhibit AD rates 1.5 times higher and average onset 7 years earlier than do older whites. Predicted growth of the US Hispanic population, particularly faster in Texas, portends further exacerbation of the disproportion- ate health and economic burdens of elevated AD in Hispanics. There is a shortage of researchers focused on AD and related disorders (ADRD) in Hispanics, particularly from underrepresented racial/ethnic groups. To overcome these barriers, the proposed AD Resource Center for Minority Aging Research (AD-RCMAR) at the University of Texas Rio Grande Valley (UTRGV), one of the nation's largest Hispanic-serving institutions, will combine evidence-based mentoring and support mechanisms to develop and promote a first-rate regional and national cadre of researchers, particularly from under-represented groups, to analyze the complex mecha- nisms and interacting factors that contribute to Hispanics' disparate vulnerabilities to AD. The Center will sup- port identification of pathways and developmental time points at which changes in social circumstances and behavior can exert the largest favorable impacts on prevention and progression of AD among Hispanics. The UTRGV AD-RCMAR will exploit its unique resources to develop infrastructure and data collections that will at- tract and support researchers from multiple disciplines and at different scientific career stages, and allow them to conduct research aimed at reducing the impacts of AD on Hispanics. The socio-demographic profile of UTRGV reflects that of its local community, positioning the Center uniquely to advance studies of disparities in health and health care and contribute innovative solutions to improve minorities' health. We will achieve the Center's goals via 4 specific aims: 1) to identify, engage, mentor, and provide high-quality training and individu- alized career development support to outstanding faculty, especially from underrepresented groups; 2) to sup- port innovative, high-impact multidisciplinary pilot projects; 3) to provide expertise and resources for culturally- sensitive measurement and analysis of cognitive risk factors in older Hispanics, including behavioral, neuro- psychological, neuroimaging, and cardiovascular and genetic traits; and 4) to create the necessary expertise and resources to establish longitudinal research cohorts of older Hispanics and their families. We will achieve these aims through the creation of 4 Cores (Administrative; Research Education; Analysis; and Community Liaison/Recruitment) to support AD research. The Center will build upon the experience of investigators at the UTRGV Institute of Neuroscience and collaborators at the South Texas Diabetes & Obesity Institute, and Washington University's AD Research Center.

总结 总体 阿尔茨海默病 (AD) 是一种与衰老相关的疾病，对西班牙裔/拉丁裔的影响尤为严重， 他们的 AD 发生率比老年白人高 1.5 倍，平均发病时间比老年白人早 7 年。 美国西班牙裔人口的增长，尤其是德克萨斯州的增长速度更快，预示着比例失调的进一步加剧。 西班牙裔 AD 增加带来的健康和经济负担目前缺乏关注的研究人员。 西班牙裔人的 AD 及相关疾病 (ADRD)，特别是来自代表性不足的种族/族裔群体。 为了克服这些障碍，拟议的少数族裔老龄化研究资源中心 (AD-RCMAR) 德克萨斯大学里奥格兰德河谷分校 (UTRGV) 是美国最大的拉美裔服务机构之一， 将基于证据的指导和支持机制结合起来，开发和促进一流的区域和 国家骨干研究人员，特别是来自代表性不足群体的研究人员，来分析复杂的机制 该中心将支持西班牙裔人对 AD 的不同脆弱性的各种主义和相互作用的因素。 端口识别社会环境和发展变化的路径和发展时间点 行为可以对西班牙裔 AD 的预防和进展产生最大的有利影响。 UTRGV AD-RCMAR 将利用其独特的资源来开发基础设施和数据收集，以便： 吸引和支持来自多个学科、处于不同科学职业阶段的研究人员，并允许他们 开展旨在减少 AD 对西班牙裔的影响的研究。 UTRGV 反映了当地社区的情况，使该中心具有独特的地位，可以推进对性别差异的研究。 我们将实现以下目标： 中心的目标有 4 个具体目标：1) 识别、参与、指导和提供高质量的培训和个人 2) 为杰出教师，特别是代表性不足的群体提供职业发展支持； 港口创新、高影响力的多学科试点项目；3）为文化提供专业知识和资源 对老年西班牙裔认知风险因素进行敏感测量和分析，包括行为、神经 心理、神经影像、心血管和遗传特征；4) 建立必要的专业知识； 我们将实现建立老年西班牙裔及其家庭纵向研究队列的资源。 这些目标是通过创建 4 个核心（行政、研究教育、分析和社区）来实现的。 该中心将利用研究人员的经验来支持 AD 研究。 UTRGV 神经科学研究所和南德克萨斯糖尿病与肥胖研究所的合作者，以及 华盛顿大学 AD 研究中心。