Cancer Metabolism Training Program

癌症代谢培训计划

• 批准号: 9766219
• 负责人: David K Ann
• 金额: $ 21.58万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9766219
• 关键词: Training Programs; tumor metabolism

Cancer and metabolic dysfunction are closely related, and together they create unique therapeutic challenges. City of Hope (COH), an NCI-designated Comprehensive Cancer Center (COHCCC) located in Duarte, CA, is known internationally for clinical cancer research and groundbreaking diabetes research. Therefore, the Cancer Metabolism Training Program (CMTP), supported by a rapidly growing research infrastructure at COH, will bring together research experts in cancer and metabolism to train an elite group of dedicated postdoctoral fellows. The CMTP will focus on the link between cancer and metabolism, thereby connecting the long- standing COHCCC with the new COH Diabetes and Metabolism Research Institute. Faculty preceptors will direct research training in four primary areas: 1) Cancer Risk, Prevention, and Metabolism; 2) Cancer Metabolism Biology and Genetics; 3) Cancer Inflammation and Immune Cell Metabolism; and 4) Metabolism- Based Cancer Treatment. The training program includes an organized core curriculum consisting of courses in scientific and career development training, with individualized attention to best achieve each trainee’s personal goals and support the individual needs of a diverse trainee population. Courses in the Responsible Conduct of Research and Methods for Enhancing Reproducibility will also be required. Other associated activities include seminars, journal clubs, data clubs, and an annual Cancer Metabolism Day. The program is designed to take advantage of the existing institutional strengths, including well-established collaborations between cancer and diabetes/metabolism researchers. The CMTP has drawn 25 mentors from 12 departments, all of whom have robust funding profiles with high-profile publications, and are dedicated to preparing early career scientists for leadership roles in cancer research. Six promising early-career investigators will serve as co-mentors and participate in mentor development activities. The 3 NIH T32-supported postdoctoral trainees, supported for up to 3 years, will be selected through a rigorous process, including a personal interview. Trainees will be evaluated on their publications, applications for external funding, and participation in CMTP activities. The outstanding support from COH leadership includes 1) an additional trainee position for every underrepresented minority trainee recruited, up to a total of 6 positions; 2) salary supplementation for all CMTP trainees; 3) a stipend for research supplies; and 4) full administrative and faculty salary support. Each trainee will establish a Mentoring Committee, which will include a physician to expedite translational research. The CMTP leadership will include a Recruitment Committee to oversee national recruitment efforts, a Curriculum and Training Committee to oversee course development, an Executive Committee to evaluate and modify program components, and an Internal and External Advisory Board to independently assess program progress. The overall goal of the CMTP is to assist the transformation of promising researchers into strong independent, funded scientists with the capacity to make contributions that improve human health.

癌症和代谢功能障碍密切相关，它们共同带来了独特的治疗挑战。 City of Hope (COH) 是 NCI 指定的综合癌症中心 (COHCCC)，位于加利福尼亚州杜阿尔特， 因临床癌症研究和突破性糖尿病研究而享誉国际。 癌症代谢培训计划 (CMTP) 在 COH 快速发展的研究基础设施的支持下， 将汇集癌症和代谢领域的研究专家，培养一支敬业的博士后精英团队 CMTP 将重点关注癌症与新陈代谢之间的联系，从而将长期的研究联系起来。 常驻 COHCCC 与新的 COH 糖尿病和代谢研究所的教师导师将一起。 四个主要领域的直接研究培训：1) 癌症风险、预防和代谢；2) 癌症； 代谢生物学和遗传学；3) 癌症炎症和免疫细胞代谢；4) 代谢- 基于癌症治疗的培训计划包括有组织的核心课程，其中包括以下课程： 科学的职业发展培训，注重个性化，最大限度地实现每位学员的个人发展 责任行为课程的目标并支持不同学员群体的个人需求。 还需要增强可重复性的研究和方法，包括其他相关活动。 该计划旨在举办研讨会、期刊俱乐部、数据俱乐部和一年一度的癌症代谢日。 利用现有的机构优势，包括癌症和癌症之间的良好合作 CMTP 吸引了来自 12 个部门的 25 名导师，他们都拥有丰富的经验。 强大的资金状况和备受瞩目的出版物，并致力于为早期职业科学家做好准备 六名有前途的早期职业研究人员将担任共同导师和癌症研究的领导角色。 参与导师发展活动 3 名 NIH T32 支持的博士后实习生，支持最多 为期 3 年，将通过严格的流程选拔学员，其中包括个人面试。 对他们的出版物、外部资金申请以及 CMTP 活动的参与进行了评估。 COH 领导层的出色支持包括 1) 为每个代表性不足的人提供一个额外的实习生职位 招募少数族裔实习生，最多共6个职位；2）为所有CMTP实习生提供工资补贴； 研究用品津贴；以及 4) 每位学员将建立全额行政和教员工资支持。 指导委员会，其中将包括一名医生，以加快转化研究 CMTP 领导层。 将包括一个负责监督全国招聘工作的招聘委员会、一个课程和培训 监督课程开发的委员会，评估和修改计划的执行委员会 组成部分，以及内部和外部顾问委员会来独立评估项目进展。 CMTP的总体目标是帮助有前途的研究人员转变为强大的独立性， 资助有能力为改善人类健康做出贡献的科学家。