Biopsychosocial Mechanisms Linking Gender Minority Stress to HIV Comorbidities

将性别少数压力与艾滋病毒合并症联系起来的生物心理社会机制

基本信息

批准号：
9765399
负责人：
TONIA C POTEAT
金额：
$ 66.85万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9765399
关键词：
Address Adult Anti-Retroviral Agents Appearance Behavioral Biological Biological Markers Cardiovascular Diseases Caring Chronic stress Clinical Comorbidity Complex Data Emotional Enrollment Epidemiologist Event Face Funding Gender Gender Identity Goals Gonadal Steroid Hormones HIV Health Health Promotion High Prevalence Immune Individual Infrastructure Intervention Interview Knowledge Laboratories Latina Link Longitudinal Studies Major Depressive Disorder Measures Mediating Mediator of activation protein Mental Health Metabolic Methods Neurosecretory Systems Outcome Participant Pathway interactions Pharmaceutical Preparations Physiological Physiology Population Poverty Prejudice Process Prospective Studies Prospective cohort Race Reporting Research Respondent Risk Risk Factors Role Scientist Severities Specimen Stress Structure Suicide attempt Surveys Symptoms United States United States National Institutes of Health Ursidae Family Viral Woman biopsychosocial cardiovascular disorder risk cigarette smoke clinical practice cohort ethnic minority population experience gender minority health disparity health equity high risk hormone therapy innovation intersectionality meetings mortality mortality risk multidisciplinary novel physical conditioning pressure protective factors psychological distress psychosocial public health relevance racial and ethnic racial minority social social stigma stem suicidal risk transgender transgender women

项目摘要

Project Summary/Abstract Despite a high prevalence of HIV among gender minority women, very little is known about HIV comorbid conditions in this population. Understanding the mechanisms of underlying HIV-related comorbidities in this health disparity population is an important step toward advancing health equity. The address this gap in knowledge, the study seeks to elucidate pathways linking stigma and physiologic stress to HIV comorbidities among Black and Latina gender minority women. The specific aims of the project include to: (1) quantify the longitudinal relationship of stigma to chronic stress biomarkers; (2) identify pathways linking chronic stress biomarkers to HIV comorbidities; and (3) examine the role of chronic stress in pathways linking stigma, sex hormones, and HIV comorbidities. These aims will be met using existing NIH-funded cohort platforms to enroll and follow 200 participants in a 24-month, mixed-methods, prospective study to measure stigma, biomarkers of chronic stress, sex hormones, mental health, and CVD risk. Data will be collected at baseline, 6-, 12-, 18-, and 24-months. This longitudinal study blends in-depth-interviews and quantitative psychosocial research with clinical and biological measures to advance understanding of the complex relationships between social experiences and physical health. This innovative research will identify mechanisms underlying associations between stigma and HIV comorbidities. It has important implications for interventions with health disparity populations living with HIV and will provide novel information that can be used to guide clinical practice and reduce health disparities.

项目概要/摘要尽管少数性别妇女中艾滋病毒感染率很高，但人们对艾滋病毒知之甚少该人群的合并症。了解 HIV 相关的潜在机制这种健康差异人群的合并症是促进健康公平的重要一步。为了解决这一知识差距，该研究试图阐明将耻辱感与耻辱感联系起来的途径。黑人和拉丁裔少数族裔女性艾滋病毒合并症的生理压力。具体的该项目的目标包括：(1) 量化耻辱与慢性压力的纵向关系生物标志物； (2) 确定慢性应激生物标志物与艾滋病毒合并症之间的联系途径；和（3）研究慢性压力在耻辱、性激素和艾滋病毒合并症之间的联系途径中的作用。这些目标将通过使用 NIH 资助的现有队列平台来注册和跟踪 200 名参与者来实现在一项为期 24 个月的混合方法前瞻性研究中，测量耻辱感、慢性压力的生物标志物、性别激素、心理健康和心血管疾病风险。数据将在基线、6、12、18 和 24 个月时收集。这项纵向研究将深入访谈、定量心理社会研究与临床相结合和生物学措施，以促进对社会之间复杂关系的理解经验和身体健康。这项创新研究将确定潜在的机制耻辱与艾滋病毒合并症之间的关联。它对于干预措施具有重要意义艾滋病毒感染者的健康差距，并将提供可用于指导的新信息临床实践并减少健康差距。