UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain

加州大学旧金山分校以患者为中心的慢性腰痛机制表型核心中心

基本信息

批准号：
9898132
负责人：
JEFFREY C. LOTZ
金额：
$ 2940.88万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-25 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9898132
关键词：
Adopted Advisory Committees Anatomy Ancillary Study Archives Back Pain Biological Biology Biomechanics Blood specimen Brain imaging California Chronic Chronic low back pain Clinic Clinic Activity Clinical Clinical Data Clinical Research Clinical Sciences Clinical Treatment Clinical assessments Common Data Element Communication Communities Cytometry Data Data Set Diagnostic Disease Educational Curriculum Electronic Health Record Enrollment Etiology Fostering Functional disorder Funding Future Genomics Goals Hospitals Image Imaging Device Informatics Infrastructure Institutes Investigation Knowledge Lead Longitudinal cohort Low Back Pain Machine Learning Measures Medicine Methods Mission Modeling Monitor Motion Musculoskeletal National Institute of Arthritis and Musculoskeletal and Skin Diseases Outcome Outcome Measure Pain Pathology Pathway interactions Patient Care Patient advocacy Patient-Focused Outcomes Patients Phenotype Physical Function Population Prevention strategy Psychology Questionnaires Reporting Research Research Personnel Research Project Grants Resources Role Sampling Scientist Severities Structure Supervision Symptoms Technology Therapeutic Intervention Tissue Sample Tissues Transcend Translational Research Translations United States United States National Institutes of Health Universities Variant Vertebral column Visit analytical tool biobehavior biopsychosocial central pain clinical care clinical imaging clinical pain clinical practice cohort deep learning digital disability improved improved outcome insight instrument interdisciplinary collaboration learning strategy novel novel diagnostics novel therapeutics outcome forecast pain patient pain processing patient oriented personalized medicine prediction algorithm prescription opioid programs psychologic ranpirnase social symposium targeted treatment tool treatment optimization treatment response wearable device

项目摘要

The proposed UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain (UCSF REACH) will be an interdisciplinary consortium of basic and clinical scientists dedicated to understanding and clarifying the biopsychosocial mechanisms of chronic low back pain (cLBP). The goal of UCSF REACH is to define chronic low back pain (cLBP) phenotypes and pain mechanisms that can lead to effective, personalized treatments for patients across the population. A fundamental challenge for improving lives of cLBP patients is that pain can perpetuate and worsen as a result of dynamic interaction among several patient-specific factors. However, the principle factors and their interactions remain obscure because they haven't been rigorously investigated in a single longitudinal cohort. REACH proposes to overcome this obstacle by forming a linkage between researchers who study disease biology, experts who develop advanced investigational tools and methods, scientists who analyze vast archives of clinical data, and practitioners who actively treat patients. UCSF REACH proposes six cores: 1) Administrative Core; 2) Clinical Core; 3) Informatics Core; 4) Bio-behavioral Core; 5) Pathophysiology Core; and 6) Physical Function and Biomechanics Core. These cores will provide support to a single research project that is focused on the challenge of developing validated and adoptable tools that enable comprehensive yet routine clinical assessment and treatment of CLBP patients. REACH will also foster scientific exchange through an Enrichment Program; the curriculum includes seminars featuring local and visiting scientists, an annual full-day retreat with the External Advisory Committee, and half- day symposia with a rotating topic relevant to the biopsychosocial model of cLBP. Another vital component of REACH is its Pilot/Ancillary Studies Program. This provides seed money to leverage REACH clinical data and cores. Overall, the object of REACH is to make optimum use of all available resources to catalyze discovery and translation of novel diagnostics and therapeutics that improve outcomes of cLBP patients.

拟议的 UCSF 慢性腰痛以患者为中心的机械表型核心中心（UCSF REACH）将是一个由基础和临床科学家组成的跨学科联盟，致力于了解并阐明慢性腰痛（cLBP）的生物心理社会机制。加州大学旧金山分校 REACH 的目标旨在定义慢性腰痛 (cLBP) 表型和可导致以下症状的疼痛机制：为整个人群的患者提供有效、个性化的治疗。一个根本性的挑战改善 cLBP 患者的生活的一个原因是，由于患者之间的动态相互作用，疼痛可能会持续存在并恶化。一些患者特定因素。然而，主要因素及其相互作用仍然模糊，因为尚未在单个纵向队列中对它们进行严格的研究。 REACH 建议克服这一问题通过在研究疾病生物学的研究人员和开发先进技术的专家之间建立联系来克服障碍研究工具和方法、分析大量临床数据的科学家以及积极救治患者。 UCSF REACH 提出了六个核心：1）行政核心； 2）临床核心； 3）信息学核; 4）生物行为核心； 5）病理生理学核心； 6) 身体机能和生物力学核心。这些核心将为单个研究项目提供支持，该项目专注于开发经过验证的挑战以及可采用的工具，能够对 CLBP 患者进行全面而常规的临床评估和治疗。 REACH 还将通过浓缩计划促进科学交流；课程包括研讨会以当地和访问科学家为特色，每年与外部咨询委员会一起进行全天务虚会，以及半日间研讨会的主题与 cLBP 的生物心理社会模型相关。另一个重要组成部分 REACH 是其试点/辅助研究计划。这提供了种子资金来利用 REACH 临床数据和核心。总体而言，REACH 的目标是充分利用所有可用资源来促进发现和转化可改善 cLBP 患者预后的新型诊断和治疗方法。