Integrated Multimodal Catheter Imaging of the Heart

心脏综合多模态导管成像

基本信息

批准号：
7626780
负责人：
Dirar Shafiq Khoury
金额：
$ 31.46万
依托单位：
METHODIST HOSPITAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-01-01 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7626780
关键词：
Ablation American Anatomy Arrhythmia Belief Benefits and Risks Biomedical Engineering Blood flow Canis familiaris Cardiac Cardiac Catheterization Procedures Catheterization Catheters Cessation of life Clinical Complement Complex Congestive Heart Failure Costs and Benefits Deterioration Diagnosis Diagnostic Disease Funding Grant Heart Heart failure Image Imaging Techniques Maps Measures Mechanics Methods Modeling Morbidity - disease rate Multimodal Imaging Myocardial Operative Surgical Procedures Outcome Patient Care Patients Physiological Prevalence Procedures Research Research Personnel Research Project Grants Site System Transducers United States National Institutes of Health Validation Ventricular Ventricular Tachycardia base heart function heart imaging heart rhythm hemodynamics improved mortality novel prototype success sudden cardiac death

项目摘要

DESCRIPTION (provided by applicant): Heart rhythm disorders (arrhythmias) result in significant morbidity and mortality. The need for improving the management of several types of complex arrhythmias has demanded a better understanding of these disorders particularly in relation to underlying anatomy and physiological outcome. This requisite has led to employing multiple noninvasive as well as catheter-based imaging techniques before, during, or after catheterization procedures that are however performed independent of one another. As a result of NIH funding for four years, we successfully developed a prototype catheter system and relevant methods for novel fusion of electrical activity with true cardiac anatomy acquired during catheterization. The objective of this competing continuation application is to develop a catheter-based, cardiac electrophysiological imaging system that not only maps single-beat electrical activity at multiple endocardial sites, but also detects several physiologic parameters and brings them all into the same anatomical reference. The hypothesis is that a noncontact catheter system, that carries both (1) a multielectrode probe for detecting intracavitary potentials from multiple directions and (2) a central echocardiographic transducer for acquiring three-dimensional cardiac anatomy, can provide intracardiac multimodal imaging capabilities that grant coordinated measures of electrical activity, anatomy, function, myocardial blood flow, and hemodynamics. Therefore, we will: (1) further develop a noncontact catheter-system and expand its hardware capabilities for multimodal intracardiac imaging; (2) advance novel mathematical methods to derive several cardiac physiologic parameters from images recorded by the integrated catheter system; and (3) validate the multimodal catheter imaging system and associated methods in canine heart models relevant to clinical situations. The catheter system can be introduced into the heart without surgery, and can provide safe and efficient means to diagnose causes and consequences of abnormal heart rhythms and to elucidate effects of therapy. The proposed research focuses on image-guided diagnosis with the belief that diagnostic physiologic parameters would further complement electric-anatomic end-points during cardiac catheterization. In line with a Bioengineering Research Grant, the research develops a system the outcome of which is to improve the benefit-risk and benefit-cost relationships of patient care and advance heart rhythm-related research.

描述（由申请人提供）：心律障碍（心律不齐）导致显着的发病率和死亡率。改善几种复杂心律不齐的几种类型的管理的需求要求对这些疾病有更好的了解，尤其是与潜在的解剖结构和生理结果有关。这种必要的导致在彼此独立执行的导管插入程序之前，期间或之后采用了多种非侵入性和基于导管的成像技术。由于NIH的资金已有四年了，我们成功地开发了一种原型导管系统和相关方法，用于在导管插入过程中获得真正的心脏解剖结构与真正的心脏解剖结构的新型融合。这种竞争性延续应用的目的是开发基于导管的心脏电生理成像系统，该系统不仅在多个心内膜部位绘制单孔电活动，而且还检测到几个生理参数，并将它们全部带入相同的解剖学参考。 The hypothesis is that a noncontact catheter system, that carries both (1) a multielectrode probe for detecting intracavitary potentials from multiple directions and (2) a central echocardiographic transducer for acquiring three-dimensional cardiac anatomy, can provide intracardiac multimodal imaging capabilities that grant coordinated measures of electrical activity, anatomy, function, myocardial blood flow, and血液动力学。因此，我们将：（1）进一步开发非连接导管系统，并扩大其硬件功能以进行多模式内成像；（2）提前的新数学方法从集成导管系统记录的图像中得出几个心脏生理参数；（3）验证与临床情况相关的犬心脏模型中的多模式导管成像系统和相关方法。可以在不手术的情况下将导管系统引入心脏，并可以提供安全有效的手段来诊断异常心律的原因和后果并阐明治疗的作用。拟议的研究重点是图像引导的诊断，并认为诊断性生理参数将在心脏导管期间进一步补充电 - 动态终点。根据生物工程研究赠款，该研究开发了一个系统，其结果是改善患者护理的利益风险和利益成本的关系，并提高与心律有关的研究。