Systems Approach to Understanding Cardiac Arrhythmias Mechanisms

了解心律失常机制的系统方法

• 批准号: 9763307
• 负责人: Donald M Bers
• 金额: $ 3万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763307
• 关键词: Area; Arrhythmia; Cardiac; Cause of Death; Cell Communication; Clinical; Collaborations; Communication; Communities; Complex; Computer Simulation; Consensus; Contractile System; Coupling; Data; Experimental Models; Feedback; Formulation; Generations; Goals; Grant; Heart; Heart Diseases; Hispanics; Homeostasis; Interdisciplinary Study; International; Investigation; Ion Channel; Journals; Knowledge; Link; Mathematics; Measurement; Mechanics; Minority; Modeling; Molecular; Myocardial dysfunction; Na(+)-K(+)-Exchanging ATPase; Nature; Nonlinear Dynamics; Oral; Organ; Paper; Participant; Pharmacotherapy; Physicians; Potassium Channel; Property; Publications; Publishing; Research; Research Personnel; Ryanodine Receptors; Scientific Evaluation; Scientist; Series; Signal Transduction; Study models; System; Time; Tissues; Treatment Efficacy; Woman; Work; design; dynamic system; effective therapy; experimental study; heart function; insight; interdisciplinary collaboration; knowledge integration; mathematical model; mechanotransduction; new therapeutic target; programs; success; symposium; tool; web site

ABSTRACT Heart diseases are the No.1 cause of death in the US and developed world, but effective drug therapies are still lacking. In order to develop better and more effective therapies to treat heart diseases, it is critically important for physicians and scientists to gain accurate and in-depth understanding of the cellular and molecular mechanisms of heart diseases. In recent decades, researchers in the field have been accumulating more and more experimental data from molecular, to cellular, and to tissue and organ levels. However, important conceptual advances in the cardiac field require integration of the knowledge from multiple scales. Here we take the necessary step forward to integrate experimental data into quantitative models that enable using mathematical tools and computational power to understand the complex interactions of the cells and molecules in the heart. The unique design of this conference series is to combine experimental study and mathematical modeling to achieve in-depth understanding of the non- linear dynamic systems that control cardiac function and heart diseases. This conference is the 6th in our interdisciplinary symposium series entitled “System’s Approach to Understand Cardiac Excitation-Contraction Coupling”. The previous 5 conferences have received overwhelmingly positive evaluations from scientific community and resulted in numerous high impact publications. This proposed conference will continue the uniquely interdisciplinary format to combine experimental and modeling studies in the field of cardiac arrhythmias. The topics will be focused on the cutting-edge research in cardiac excitation, Ca2+ signaling, contraction mechanics and mechanotransduction, with emphases on integrating the the dynamic systems to gain a holistic and comprehensive understanding of heart diseases. The goal of this conference will be focused on (1) summarizing current state of research in the focus area, (2) identifying consensus and controversy that warrant more investigation, (3) exchanging ideas, data, and information among the experimentalists and modelers to facilitate interdisciplinary collaborations. The conference results will be summarized in the form of white papers to be published in leading scientific journals that have broad impact in heart disease field.

抽象的 心脏病是美国和发达国家的第一大死因，但有效的药物 仍然缺乏治疗方法，以开发更好、更有效的治疗心脏病的方法。 对于医生和科学家来说，准确、深入地了解疾病至关重要 近几十年来，人们对心脏病的细胞和分子机制的了解。 该领域的研究人员一直在积累越来越多的实验数据 然而，重要的概念进展。 心脏领域需要整合多个尺度的知识。 将实验数据整合到定量模型中是必要的一步，以便能够使用 数学工具和计算能力来理解细胞复杂的相互作用 本次会议系列的独特设计是将其与心脏中的分子结合起来。 实验研究和数学建模，以深入了解非 控制心脏功能和心脏病的线性动态系统。 这次会议是我们题为“系统的”跨学科研讨会系列的第六次会议 理解心脏兴奋-收缩耦合的方法”。前 5 次会议。 得到了科学界压倒性的积极评价，并取得了 拟议的会议将继续发表许多高影响力的出版物。 跨学科形式将心脏领域的实验和建模研究结合起来 主题将集中在心脏兴奋、Ca2+ 的前沿研究。 信号传导、收缩力学和机械传导，重点是整合 动态系统以获得对心脏病的整体和全面的了解。 本次会议的目标将集中于（1）总结该领域的研究现状 重点领域，(2) 确定需要更多调查的共识和争议，(3) 在实验者和建模者之间交换想法、数据和信息，以促进 跨学科合作的成果将以白色的形式进行总结。 论文将发表在在心脏病领域具有广泛影响的领先科学期刊上。