Systems Approach to Understanding Cardiovascular Disease and Arrhythmias - Cell diversity in the cardiovascular system, cell-autonomous and cell-cell signaling

了解心血管疾病和心律失常的系统方法 - 心血管系统中的细胞多样性、细胞自主和细胞间信号传导

• 批准号: 10386681
• 负责人: Donald M Bers
• 金额: $ 3万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-23 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10386681
• 关键词: Area; Arrhythmia; Biophysics; Black race; Blood Vessels; Cardiac; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cause of Death; Cell Communication; Cells; Collaborations; Communication; Communities; Complex; Computer Models; Consensus; Coupling; Data; Databases; Development; Disabled Persons; Disease; Disease Progression; Endothelial Cells; Endothelium; Evaluation; Event; Experimental Models; Feedback; Fibroblasts; Formulation; Functional disorder; Goals; Grant; Heart; Heart Diseases; Heart failure; Hypertension; Immune; Individual; Interdisciplinary Study; International; Investigation; Journals; Knowledge; Latin America; Link; Mathematics; Minority; Minority Groups; Minority Participation; Minority Women; Mission; Modeling; Molecular; Muscle Cells; National Heart, Lung, and Blood Institute; Nature; Neurons; Nonlinear Dynamics; Oral; Organ; Outcome; Paper; Participant; Persons; Physicians; Physiology; Play; Property; Publications; Publishing; Research; Research Personnel; Role; Scientist; Series; Signal Transduction; Smooth Muscle Myocytes; Societies; Stroke; Study models; System; Therapeutic; Time; Tissues; United States; Vascular Diseases; Vascular Smooth Muscle; Vasospasm; Woman; Work; career; career networking; cell type; complex biological systems; design; dynamic system; effective therapy; experimental study; innovation; intercellular communication; interdisciplinary collaboration; mathematical model; meetings; novel therapeutic intervention; programs; social media; success; symposium; tool; web site

UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiovascular Disease and Arrhythmias -Cell diversity in the cardiovascular system, cell-autonomous and cell-cell signaling- Cardiovascular diseases, including hypertension, heart failure, arrhythmias and stroke, are the number one killer in the developed world. In order to develop better and more effective therapies to treat heart diseases, it is critically important for scientists and physicians to obtain in-depth and accurate understanding of the mechanisms underlying heart and vascular function and dysfunction. In recent decades, researchers studying heart and vascular diseases have been accumulating more and more experimental data from molecular, to cellular, and to tissue and organ levels. However, there is a critical need to integrate these data into mechanistic and quantitative models to understand emergent properties of complex biological system such as arrhythmias and vasospasms that are often counterintuitive (due to non-linear dynamics interactions). Moreover, it is important to understand how different cells of the cardiovascular system may interact with each other in physiology and disease. Here we propose to take the necessary step forward to integrate experimental data into quantitative models that enable using mathematical tools and computational power to understand the complex interactions of the cells and molecules in the cardiovascular system. The unique design of this conference series is to combine experimental study and mathematical modeling to achieve in-depth understanding of the dynamic systems that control cardiovascular function and diseases. The proposed interdisciplinary conference is the 7th in this series. This new installment of the conference will integrate, for the first time, studies in cardiac and vascular tissue. The previous conferences have received overwhelmingly positive evaluations from attendees and resulted in high impact publications. The proposed conference will combine experimental and modeling studies in the field of cardiac and vascular physiology, with topics focused on cell diversity in the cardiovascular system, as it is becoming increasingly evident that a complex interplay of abnormal signaling events among various cell types, including myocytes, fibroblasts, endothelial, neuronal, immune cells, etc. plays a central role in cardiovascular disease. The emphasis of this conference will be on (1) summarizing current state of research in the focus area, (2) identifying consensus and controversy that warrant more investigation, and (3) exchanging ideas, data, and information among the experimentalists and modelers to facilitate interdisciplinary collaborations. The conference results will be summarized in the form of comprehensive review papers, which will be published in leading scientific journals that have broad impact on the research community, as before.

加州大学戴维斯分校心血管研讨会 了解心血管疾病和心律失常的系统方法 -心血管系统中的细胞多样性、细胞自主和细胞间信号传导- 心血管疾病，包括高血压、心力衰竭、心律失常和中风，是第一大杀手 在发达国家。为了开发出更好、更有效的治疗心脏病的疗法， 对于科学家和医生来说，深入、准确地了解这一点至关重要。 心脏和血管功能和功能障碍的机制。近几十年来，研究人员研究 心脏和血管疾病已经积累了越来越多的从分子、到 细胞水平、组织和器官水平。然而，迫切需要将这些数据整合到机械系统中 和定量模型来了解复杂生物系统的新兴特性，例如心律失常 以及通常违反直觉的血管痉挛（由于非线性动力学相互作用）。而且，它是 了解心血管系统的不同细胞如何相互作用非常重要 生理学和疾病。在这里，我们建议采取必要的步骤将实验数据整合到 定量模型能够使用数学工具和计算能力来理解复杂的事物 心血管系统中细胞和分子的相互作用。本次会议系列的独特设计 就是将实验研究和数学建模相结合，以达到对动态的深入理解 控制心血管功能和疾病的系统。拟议的跨学科会议是第七届 在这个系列中。会议的这一新部分将首次整合心脏和 维管组织。往届会议均获得了与会者的积极评价 并产生了高影响力的出版物。拟议的会议将结合实验和建模 心脏和血管生理学领域的研究，主题集中在心血管细胞多样性 系统中，越来越明显的是，异常信号事件之间的复杂相互作用 各种细胞类型，包括肌细胞、成纤维细胞、内皮细胞、神经元、免疫细胞等发挥着核心作用 在心血管疾病中。本次会议的重点是（1）总结研究现状 在重点领域，（2）确定需要更多调查的共识和争议，以及（3）交换意见 实验者和建模者之间的想法、数据和信息，以促进跨学科合作。 会议成果将以综合综述论文的形式总结并发表 一如既往地在对研究界产生广泛影响的领先科学期刊上发表文章。