Animal Core

动物核心

基本信息

批准号：
7706294
负责人：
KRISTEN A BERNARD
金额：
$ 92.08万
依托单位：
WADSWORTH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-03-01 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7706294
关键词：
Acute Address Agreement Animal Diseases Animal Model Animals Arts Bacterial Model Birds Buffaloes Caribbean natives Caribbean region Categories Cavia Collaborations Communities Containment Core Facility Development Diagnostic Disease Emergency Situation Event Funding Future Genetic Goals Hamsters Host Defense Immune response Infectious Diseases Research Institutes Institution Investigation Island Laboratories Livestock Maryland Modeling Mus Oryctolagus cuniculus Pathogenicity Plum Predisposition Primates Puerto Rico Rattus Research Research Personnel Research Project Grants Resistance Resources Rodent Role Scientist Services Site Testing Therapeutic Training Transgenic Mice Transgenic Organisms Translational Research Universities Viral Virulence animal facility improved investigator training member nonhuman primate novel vaccines pathogen therapeutic vaccine

项目摘要

A primary goal of this application is the development of new vaccines, diagnostics, and therapeutics for category A-C priority agents. Animal models will be needed to improve our understanding of the hostpathogen relationship and to test newly developed products. Since many of the pathogens require BSL-3 containment, state-of-the-art BSL-3 vivaria will be critical in reaching our research goals. Thus, we have established an Animal Core in order to the meet the current and expanding needs of NBC scientists. The objectives of the Animal Core are: 1) to provide high quality BSL-3 animal facilities; 2) to advise and train investigators in animal models for category A-C priority agents; and 3) to encourage collaborations between NBC members. The NBC Animal Core consists of BSL-3 vivaria at four sites within region 2 and provides facilities for a wide variety of animal species. Small animal studies involving rodents, rabbits, and birds will be performed at one of two BSL-3 vivaria at PHRI, Newark, NJ or Wadsworth Center, Albany, NY. Studies in livestock on zoonotic pathogens will be located at the Plum Island Animal Disease Center, Plum Island, NY. Non-human primate studies will be conducted at the Caribbean Primate Research Center, Puerto Rico. The diversity of animal species available at these four facilities is essential in order to address the diversity of the category A-C priority agents. In addition, the diverse scientific expertise at these facilities will provide excellent training and collaborative opportunities for the NBC research community.

该应用的主要目标是开发新的疫苗，诊断和治疗剂对于A-C类优先代理。需要动物模型来提高我们对宿主的理解关系并测试新开发的产品。由于许多病原体需要BSL-3 遏制，最先进的BSL-3 Vivaria对于实现我们的研究目标至关重要。因此，我们有为了满足NBC科学家的当前和不断增长的需求，建立了动物核心。这动物核心的目标是：1）提供高质量的BSL-3动物设施； 2）建议和培训 A-C类优先剂的动物模型研究人员； 3）鼓励合作 NBC成员。 NBC动物核心由2区域内四个地点的BSL-3 Vivaria组成，并为各种各样的动物。将进行涉及啮齿动物，兔子和鸟类的小动物研究在新泽西州纽瓦克市PHRI的两个BSL-3 Vivaria中，或纽约州奥尔巴尼的Wadsworth Center之一。牲畜研究人畜共患病原体将位于纽约梅子岛的梅花岛动物疾病中心。非人类灵长类动物研究将在波多黎各的加勒比灵长类动物研究中心进行。多样性这四个设施可用的动物物种对于解决该类别的多样性至关重要 A-C优先代理。此外，这些设施的多元化科学专业知识将提供出色的培训 NBC研究社区的协作机会。