Chinese American Eye Study

华裔美国人眼科研究

基本信息

批准号：
7431046
负责人：
ROHIT VARMA
金额：
$ 143.66万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7431046
关键词：
Acculturation African American Age Age related macular degeneration Aging American Angle-Closure Glaucoma Anisometropia Area Asian Americans Asians Astigmatism Biology Biology of Aging Biometry Blindness Blood Glucose Body mass index C-reactive protein Caliber California Candidate Disease Gene Caring Cataract Censuses Characteristics Childhood Chinese American Chinese People Cornea County Data Demographic Factors Diabetic Angiopathies Diabetic Retinopathy Disease Education Epidemiologic Studies Ethnic group Exhibits Exudative age-related macular degeneration Eye Eye diseases Far East Fundus Genes Genetic Determinism Genotype Glaucoma Glycosylated hemoglobin A Hypertension Image Inflammatory Interleukin-6 Interview Latino Lead Length Lens Opacities Life Lipids Los Angeles Measurement Measures Methodology Myopia Not Hispanic or Latino Nuclear Open-Angle Glaucoma Ophthalmic examination and evaluation Optic Disk Optic Nerve Optical Coherence Tomography Pattern Persons Phenotype Physiologic Intraocular Pressure Population Prevalence Preventive Primary Angle Closure Glaucoma Public Health Race Refractive Errors Rehabilitation therapy Research Design Research Infrastructure Retinal Retinal Diseases Risk Risk Factors Role Sampling Serum Services Smoke Subgroup Testing Thick Ultrasonics United States Variant Venous Visual Acuity Visual Fields Visual impairment Vitreous Chamber age related aged anterior chamber arteriole base cardiovascular risk factor cycloplegic design diabetic genetic variant improved inflammatory marker lens macula macular edema metropolitan middle age non-diabetic novel population based racial and ethnic retinal nerve fiber layer study characteristics venule

项目摘要

DESCRIPTION (provided by applicant): Visual impairment and the major ocular conditions that lead to visual impairment continue to be a significant public health burden in middle-aged and older Americans. While several large, well-designed, population based ocular disease studies of US whites, blacks, and Latinos have been conducted, there is almost no information on the prevalence, risk factors, and genetic determinants in Asian Americans-one of the fastest growing racial groups in the US. There are known to be significant racial/ethnic variations in the burden of eye disease, and studies from East Asia suggest that Asians have a spectrum of eye diseases different from that of whites, African Americans, and Latinos. Because the largest Asian subgroup in the US is that of Chinese descent, in this proposed study we will determine cause-specific rates of blindness, visual impairment, and ocular disease (including cataract) in Chinese Americans aged 50 years and older. In addition, we will measure the degree to which biometric, inflammatory, and microvascular risk factors are associated with eye disease. Finally, we will examine genetic determinants of AMD and Glaucoma in this racial/ethnic group. All Chinese American residents living in the nine census tracts in Monterey Park, California, aged 50 years and older, will be invited to undergo an interview and a comprehensive eye examination, including measurement of visual acuity, visual field, intraocular pressure, hemoglobin A1c, blood glucose, and serum C-reactive protein; additional tests will include optical coherence tomography of the anterior chamber angle, ultrasonic measurement of the anterior chamber depth and lens thickness, and imaging of the fundus and optic nerve. The standardized study design and methodology will allow us to compare our data in Chinese Americans with previously obtained estimates in whites, African Americans, and Latinos. These data will improve our understanding of the biology of these age-related eye diseases. Our findings will help in planning preventive, rehabilitative, and eye care services. These findings are also likely to be of increasing public health importance, as the societal burden of age-related eye disease will likely increase with the aging of this rapidly growing segment of the US population.

描述（由申请人提供）：视觉障碍和导致视觉障碍的主要眼部状况仍然是中年和老年人的重大公共卫生负担。尽管已经进行了几项大型，精心设计的基于人群的眼部疾病研究美国白人，黑人和拉丁美洲人，但亚裔美国人中几乎没有有关美国亚裔美国人的患病率，危险因素和遗传决定因素的信息，这是美国增长最快的种族群体之一。众所周知，眼睛疾病负担有很大的种族/族裔差异，东亚的研究表明，亚洲人的眼疾病与白人，非裔美国人和拉丁美洲人不同。由于美国最大的亚洲亚组是中国血统，因此在这项拟议的研究中，我们将确定50岁及以上的华裔美国人的失明，视觉障碍和眼部疾病（包括白内障）的特定原因。此外，我们将衡量生物识别，炎症和微血管危险因素与眼病有关的程度。最后，我们将检查这个种族/族裔中AMD和青光眼的遗传决定因素。所有居住在加利福尼亚州蒙特雷公园（Monterey Park）的九个年龄50岁以上的人口普查区中的所有中国美国居民将被邀请接受访谈和全面的眼睛检查，包括测量视力，视野，眼内压力，血红蛋白A1C，血糖，血糖和血清c- c蛋白质蛋白质；其他测试将包括前室角的光学相干断层扫描，前腔深度和晶状体厚度的超声测量以及眼底和视神经的成像。标准化的研究设计和方法论将使我们能够将中国人的数据与以前获得的白人，非裔美国人和拉丁美洲人的估计值进行比较。这些数据将提高我们对这些与年龄有关的眼部疾病的生物学的理解。我们的发现将有助于计划预防，康复和眼保健服务。这些发现也可能提高公共卫生的重要性，因为随着年龄相关的眼科疾病的社会负担，随着这一迅速增长的美国人口的衰老，可能会增加。