SIV CARDIOMYOPATHY: PATHOGENESIS AND PREVENTION

SIV 心肌病：发病机制和预防

• 批准号: 7562005
• 负责人: Richard P Shannon
• 金额: $ 19.06万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562005
• 关键词: Acquired Immunodeficiency Syndrome; Cardiac; Cardiomyopathies; Cardiovascular system; Chronic; Computer Retrieval of Information on Scientific Projects Database; Curiosities; Funding; Grant; HIV; HIV Infections; Heart Diseases; Highly Active Antiretroviral Therapy; Individual; Institution; Life; Morbidity - disease rate; Pathogenesis; Pathologic; Pathology; Patients; Predisposition; Prevention; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV associated cardiac pathology is being recognized increasingly as patients with chronic HIV infection survive to live productive lives. HIV associated cardiomyopathy is among the most common cardiac specific manifestation of chronic HIV infection and was observed in between 6-12% of patients that succumb to AIDS. However, cardiovascular involvement has emerged as more than a pathologic curiosity, but rather as a significant cause of morbidity as individuals live longer, more productive lives with HIV. Increased use of HAART therapy has served to unmask HIV associated predispositions to cardiac involvement. Despite the increased recognition, the risks factors for, the pathogenesis of, and the specific treatments required in HIV associated cardiac disease remain unknown.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 随着慢性艾滋病毒感染的患者能够生存生产力，艾滋病毒相关的心脏病理越来越多地被识别。 HIV相关的心肌病是慢性HIV感染最常见的心脏特异性表现之一，在6-12％的屈服于艾滋病的患者中观察到。然而，心血管的参与不仅仅是一种病理性的好奇心，但由于个体寿命更长，艾滋病毒的生产力更高，因此发病的重要原因。 HAART疗法的使用增加已揭露与心脏参与的HIV相关倾向。尽管识别率增加，但艾滋病毒相关心脏疾病所需的风险因素，发病机理和特定疗法仍然未知。