Proteomic Profiling of Cardiac Dysfunction in the MACS-WIHS Combined Cohort Study."

MACS-WIHS 联合队列研究中心脏功能障碍的蛋白质组学分析。”

• 批准号: 10654914
• 负责人: Kathryn M. Anastos
• 金额: $ 7.07万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654914
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Area; Atherosclerosis; Behavioral; Blood; Blood specimen; CD4 Lymphocyte Count; Calibration; Cardiac; Cardiomyopathies; Cardiovascular Diseases; Clinical; Clinical Research; Cohort Studies; Data; Development; Diabetes Mellitus; Disease; Echocardiography; Functional disorder; Funding; General Population; Generations; Genes; Genotype; HIV; HIV Seronegativity; HIV Seropositivity; Heart Abnormalities; Heart Diseases; Heart Rate; Heart failure; High Prevalence; Image; Impairment; Lead; Left; Left Ventricular Mass; Link; Measurement; Measures; Mendelian randomization; Molecular; Myocardial dysfunction; Nature; Outcome; Participant; Pathway interactions; Persons; Pharmaceutical Preparations; Pharmacotherapy; Phenotype; Plasma; Population; Preventive; Protein Analysis; Proteins; Proteomics; Quantitative Trait Loci; Reporting; Research; Research Personnel; Risk; Risk Factors; Sampling; Site; Specimen; Structure; Technology; Testing; Therapeutic; Therapeutic Uses; Training; Translational Research; United States National Institutes of Health; Ventricular; Viral; Visit; Woman; antiretroviral therapy; aptamer; clinical risk; cohort; comorbidity; drug development; gene function; health disparity; healthy volunteer; heart function; heart imaging; high risk; imaging study; improved; indexing; men; multiple omics; next generation; novel therapeutics; protein biomarkers; proteomic signature; recruit; risk prediction; secondary analysis; sudden cardiac death; targeted treatment; ultrasound

Abstract Fund Year 2023 OAR Strategic Funds are requested to perform high-throughput proteomic measurements to investigate the protein signatures of cardiac dysfunction and its progression in MWCCS. Previously collected blood specimens in participants who completed baseline echocardiography in MACS Visits 67-71 (n=1195) and WIHS Visits 44-50 (n=1655) will be used to measure proteomics in order to permit discovery of protein markers. Genotypic data in MACS and WIHS will be leveraged to conduct Mendelian randomization analysis using protein quantitative trait loci, allowing causal inference and selection of protein targets for pharmacotherapy. This supplement will support HIV/AIDS research corresponding to the following NIH high-priority AIDS-designated topics: (1) HIV-associated comorbidities; (2) cross- cutting areas involving clinical translational research, cardiovascular disease, proteomics, multi- omics, and health disparities; and (3) training of the next generation of HIV investigators in omics and comorbidities research.

抽象的 2023年OAR战略基金要求基金进行高通量蛋白质组学研究 测量以研究心脏功能障碍的蛋白质特征及其进展 MWCC。之前在完成基线的参与者中采集的血液样本 将在 MACS 就诊 67-71 (n=1195) 和 WIHS 就诊 44-50 (n=1655) 中使用超声心动图 测量蛋白质组学以便发现蛋白质标记。 MACS 中的基因型数据 WIHS 将用于使用蛋白质进行孟德尔随机化分析 数量性状位点，允许因果推断和蛋白质靶标选择 药物治疗。该增刊将支持与以下相关的艾滋病毒/艾滋病研究 以下是 NIH 高度优先的艾滋病指定主题：(1) 与艾滋病毒相关的合并症； (2) 交叉 切割领域涉及临床转化研究、心血管疾病、蛋白质组学、多学科 组学和健康差异； (3) 培训下一代艾滋病毒调查人员 组学和合并症研究。