Cartilage-Bone Interactions in Osteoarthritis

骨关节炎中的软骨-骨相互作用

• 批准号: 7387426
• 负责人: Sharmila Majumdar
• 金额: $ 46.86万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-17 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7387426
• 关键词: Accounting; Acute; Address; Adipocytes; Anterior Cruciate Ligament; Architecture; Arthritis; Biochemical; Bone Marrow; Bone and Cartilage Funding; Cartilage; Cartilage Matrix; Characteristics; Collagen; Contralateral; Contrast Media; Contusions; Defect; Degenerative polyarthritis; Edema; Elevation; Enrollment; Environment; Fatty acid glycerol esters; Femur; Gadolinium DTPA; Gadopentetate Dimeglumine; Grant; Hemorrhage; Image; Impairment; Injury; Joints; Knee; Knee joint; Lateral; Localized Disease; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Marrow; Measurement; Measures; Medial; Metric; Morphology; Muscle; Necrosis; Noise; Numbers; Pain; Patients; Population Control; Proteoglycan; Protons; Pyrococcus kodakaraensis TIP protein; Recording of previous events; Relaxation; Research; Research Personnel; Role; Scanning; Sclerosis; Score; Severities; Severity of illness; Signal Transduction; Specimen; Spectrum Analysis; Structure; Swelling; Symptoms; Synovial Membrane; Thick; Time; Tissues; Water; Weight; articular cartilage; base; bone; bone imaging; cohort; experience; follow-up; improved; interest; knee replacement arthroplasty; programs; saturated fat; size; substantia spongiosa; tibia; uptake

This competing renewal focuses on using Magnetic Resonance (MR) imaging at 3 Tesla to study oint degeneration and the manifested changes in articular cartilage, subchondral bone, peri-articular trabecular bone and bone marrow. Articular degeneration and progression of osteoarthritis (OA) may be preceded and/or accompanied by changes in subchondral and trabecular bone, and bone marrow. This competing renewal grant aims to utilize the strengths of our research environment and group and extend the study of OA to include trabecular bone structure measures, Tip of cartilage, and MR (proton) spectroscopy to characterize the adjoining bone marrow, in the study of OA. Using accepted parameters such as cartilage volume and T2 relaxation for comparison, we hypothesize that: ¿ T2 and T1p are independently associated with cartilage loss and longitudinal progression of OA; Changes of trabecular bone micro-architecture is associated with cartilage loss and progression of OA; MR spectroscopy (MRS) marrow fat/water contents are correlated with histological measurements, and bone marrow edema characteristics are different between OA and acute injury; In addition to size of bone marrow edema, bone marrow edema fat/water and unsaturated/saturated fat composition are associated with cartilage loss and progression of OA. To address these we have the following aims: SPECIFIC AIM I: To evaluate the relationship of T2. T-inrelaxation times, and trabecular bone structure to cartilage loss and OA progression. Three groups of subjects (n=35/group) will be studied longitudinally for three years for Specific Aim I: healthy control population of subjects with no history of knee impairment; Group II, patients with mild arthritic symptoms and radiographic changes (Kellgren Lawrence score of 2); Group III,patients with severe pain and functional limitations associated with knee arthritis (KL score of 3,4). SPECIFIC AIM II: To examine the MRS based water/fat compositions of bone marrow edema for patients with OA and acute injuries, and to evaluate their relationship to cartilage loss and OA progression. An additional cohort consisting of consist of patients with acute anterior cruciate ligament (ACL) injuries with associated osseous contusion (n=20) will also be followed.

这种竞争的更新重点是在3特斯拉进行磁共振（MR）成像进行研究 OINT变性以及关节软骨，软骨下骨，关节周围的明显变化 小梁骨和骨髓。骨关节炎（OA）的人工变性和进展可能是 在和/或伴随着软骨下和小梁骨以及骨髓的变化。这 竞争的更新赠款旨在利用我们的研究环境和小组的优势，并扩展 OA的研究包括小梁骨结构测量，软骨尖端和MR（质子）光谱 在OA的研究中表征相邻的骨髓。使用可接受的参数，例如软骨 卷和T2放松以进行比较，我们假设： T2和T1P与软骨损失和OA的纵向进程独立相关； 小梁骨微体系结构的变化与软骨丧失和OA的进展有关。 MR光谱法（MRS）骨髓脂肪/​​水含量与组织学测量相关，并且 OA和急性损伤之间的骨髓水肿特性不同。 除了骨髓水肿的大小，骨髓水肿脂肪/水和不饱和/饱和脂肪 组成与软骨损失和OA的进展有关。为了解决这些问题，我们有 以下目的： 特定目的I：评估T2的关系。 T侵出时间和小梁骨结构到 软骨损失和OA进展。三组受试者（n = 35/组）将纵向研究 特定目的I的三年：没有膝盖障碍史的受试者的健康控制人群； 第二组，具有轻度关节符号的患者和射线照相变化（Kellgren Lawrence评分为2）； 第三组，患有严重疼痛和功能限制的患者与膝关节炎有关（KL评分为3,4）。 特定目标II：检查患者骨髓水肿的基于MRS的水/脂肪组成 OA和急性损伤，并评估它们与软骨损失和OA进展的关系。一个 由急性前交叉韧带（ACL）损伤组成的其他队列 还将遵循相关的骨挫伤（n = 20）。