Center for Research in Diagnostics and Discovery

诊断与发现研究中心

• 批准号: 9440950
• 负责人: W. Ian Lipkin
• 金额: $ 617.18万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-07 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9440950
• 关键词: Biological Assay; Biomedical Engineering; Communities; Community Health; Country; Detection; Diagnostic; Disease susceptibility; Effectiveness; Epidemic; Genetic; Geographic Locations; Infectious Agent; Instruction; Integration Host Factors; Knowledge; Medical; Methodology; Modernization; Molecular Biology; Pharmaceutical Preparations; Public Health; Research; Research Personnel; System; Systems Biology; Technology; Testing; Vaccines; accurate diagnosis; cost; diagnostic assay; improved; member; novel; pathogen; rapid diagnosis; tool

Accurate diagnosis is essential for proper medical treatment. Often this is confounded by the lack of or limitation of informative diagnostic assays and tools. Infectious agents rarely found in a given community or country commonly are not screened for as multiple single diagnostic assays are cost-prohibitive and tests for the most likely agent is deemed warranted. Yet it is increasingly clear that as infectious agents appear in , new geographic regions and contexts, the medical and public heath communities must improve and modernize the methodologies they utilize. The Center for Research in Diagnostics and Discovery aims to develop, validate and implement multiplex platforms and predictive strategies that will advance detection of novel pathogens, identify host factors that influence susceptibility of disease and predict effectiveness of drugs and vaccines. We will bring together researchers in the fields of molecular biology, systems biology, genetics, and bioengineering. We will also bring together members of the public health communities and conservation biologists. Together, the investigators in the Center for Research in Diagnostics and Discovery will advance knowledge and platforms for the detection of agents that are either previously unidentified, known causes of epidemics, or select agents by developing and utilizing systems that could be rapidly redirected for pathogens of any type.

准确的诊断对于正确的医疗至关重要。通常，这会因缺乏或 信息丰富的诊断测定和工具的局限性。在特定社区或地区很少发现传染性病原体 国家通常不会进行筛查，因为多个单一诊断检测的成本高昂，并且检测 最有可能的代理人被认为是有保证的。然而，越来越明显的是，随着传染源的出现， 新的地理区域和环境，医疗和公共卫生界必须改进和 使他们使用的方法现代化。诊断和发现研究中心旨在 开发、验证和实施多重平台和预测策略，以推进检测 新病原体，识别影响疾病易感性的宿主因素并预测其有效性 药物和疫苗。我们将汇集分子生物学、系统生物学、 遗传学和生物工程。我们还将汇集公共卫生界的成员和 保护生物学家。诊断和发现研究中心的研究人员一起 将推进用于检测以前未识别的代理的知识和平台， 流行病的已知原因，或通过开发和利用可以快速传播的系统来选择病原体 针对任何类型的病原体进行重定向。

项目成果

Identification of a novel nidovirus in an outbreak of fatal respiratory disease in ball pythons (Python regius).

在球蟒 (Python regius) 致命呼吸道疾病爆发中鉴定出一种新型巢状病毒。

• 发表时间: 2014-08-08
• 影响因子: 4.8
• 作者: Uccellini, Lorenzo;Ossiboff, Robert J;de Matos, Ricardo E C;Morrisey, James K;Petrosov, Alexandra;Navarrete;Jain, Komal;Hicks, Allison L;Buckles, Elizabeth L;Tokarz, Rafal;McAloose, Denise;Lipkin, Walter Ian
• 通讯作者: Lipkin, Walter Ian

Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A.

猪流行性腹泻病毒 PC22A 株致病性全长 cDNA 克隆的表征和传播模型。

• 发表时间: 2016-01-05
• 影响因子: 6.4
• 作者: Beall, Anne;Yount, Boyd;Lin, Chun;Hou, Yixuan;Wang, Qiuhong;Saif, Linda;Baric, Ralph
• 通讯作者: Baric, Ralph

Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome.

肌痛性脑脊髓炎/慢性疲劳综合征患者亚组的粪便宏基因组谱。

• 发表时间: 2017-04-26
• 影响因子: 15.5
• 作者: Nagy;Williams, Brent L;Mishra, Nischay;Che, Xiaoyu;Lee, Bohyun;Bateman, Lucinda;Klimas, Nancy G;Komaroff, Anthony L;Levine, Susan;Montoya, Jose G;Peterson, Daniel L;Ramanan, Devi;Jain, Komal;Eddy, Meredith L;Hornig, Mady;Li
• 通讯作者: Li

Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model.

转录谱证实了登革热疾病模型中肥大细胞稳定的治疗效果。

• 发表时间: 2017-09-15
• 作者: Morrison, Juliet;Rathore, Abhay P S;Mantri, Chinmay K;Aman, Siti A B;Nishida, Andrew;St John, Ashley L
• 通讯作者: St John, Ashley L

GII.4 Human Norovirus: Surveying the Antigenic Landscape.

GII.4 人类诺如病毒：抗原状况调查。

• 发表时间: 2019-02-20
• 作者: Mallory, Michael L;Lindesmith, Lisa C;Graham, Rachel L;Baric, Ralph S
• 通讯作者: Baric, Ralph S