Developing near-infrared responsive liquid crystal elastomers for an adjustable pulmonary artery band

开发用于可调节肺动脉带的近红外响应液晶弹性体

• 批准号: 10778190
• 负责人: Nathaniel Phillip Skillin
• 金额: $ 4.25万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-17 至 2026-08-16
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10778190
• 关键词: 3D Print; Acceleration; Acute; Address; Adopted; Affect; Animals; Arteries; Biocompatible Materials; Biological Testing; Blood; Blood flow; Body Weight; Cardiac; Catheters; Cell Culture Techniques; Cells; Cessation of life; Child; Chronic; Circulation; Clinical; Colorado; Communication; Congenital Heart Defects; Critical Congenital Heart Defects; Defect; Development; Devices; Diameter; Echocardiography; Elastomers; Elements; Engineering; Evolution; Exhibits; Fellowship; Fiber Optics; Future; Goals; Goretex; Growth; Health Care Costs; Immune response; Implant; In Vitro; Infant; International; Lasers; Life; Life Expectancy; Light; Lung; Mechanics; Mediating; Medical Device; Medical Device Designs; Medical Technology; Mentorship; Morbidity - disease rate; Mus; Near-Infrared Spectroscopy; Newborn Infant; Operative Surgical Procedures; Optics; Patient-Focused Outcomes; Patients; Penetration; Performance; Persons; Physiological; Polymer Chemistry; Polymers; Prevalence; Procedures; Publishing; Pulmonary Hypertension; Pulmonary artery structure; Quality of life; Regulation; Repeat Surgery; Reporting; Research Activity; Research Project Grants; Research Proposals; Research Training; Risk; Scientist; Second Look Surgery; Shapes; Skin; Source; Stimulus; Surface; Surface Properties; Surgeon; Technical Expertise; Techniques; Testing; Tissues; Training; Translating; Translations; Transmission Electron Microscopy; United States; Universities; Work; biomaterial compatibility; cancer therapy; career; career development; childcare allowance; constriction; cost; crosslink; cytotoxicity; cytotoxicity test; design; elastomeric; global health; hemodynamics; implantation; improved; improved outcome; in vivo; irradiation; light scattering; light transmission; liquid crystal; medical implant; minimally invasive; mortality; nanoGold; nanocomposite; nanorod; novel; optical fiber; outreach; palliate; palliation; palliative; patient prognosis; performance tests; preclinical study; pressure; response; scaffold; skills; subcutaneous; surgery material; tool

Project Summary Approximately 1 in 100 children born in the United State have a congenital heart defect (CHD). Nearly a quarter of these children present with “critical” CHDs, requiring surgical intervention within the first year of life. For patients in which a CHD is the source of pulmonary hypertension (e.g., the unrestricted flow of blood to the lungs), a palliative pulmonary artery band (PAB) can be applied to regulate blood flow. Conventional PABs are fixed and thus commit children to repeated surgeries if adjustments are needed due to altered hemodynamics and/or to accommodate growth. As a result, the affected children suffer from high morbidity and mortality. This proposal addresses this clinical need by developing and optimizing novel stimuli-responsive materials for integration with PABs to permit adjustability. Light is an ideal stimulus to introduce minimally invasive reconfigurability to the PAB. The objective of this research activity is to integrate photoresponsive materials with PABs to enable the diameter of the PAB to be reconfigured via light delivered by an endovascular fiber-optic catheter through the artery wall. Aim 1 is focused on material development and integration into novel PAB designs that leverage the stimuli-responsive material. Aim 2 will assess the cellular and host responses to the stimuli-responsive material and develop strategies to engineer these responses if necessary. Long-term, the evolution of stimuli-responsive materials will lead to a wide variety of growth-accommodating and shape-changing medical devices that will improve patient outcomes and quality of life. This collaborative research project will be undertaken at the University of Colorado Boulder with mentorship and support from Dr. Timothy White and Dr. Kristi Anseth. The training plan includes development of technical skills (e.g. polymer chemistry, medical device design, and biological testing of biomaterials) and professional skills (e.g. communication skills, career development, and scientific outreach). In sum, this application will provide the applicant with invaluable training for his future career as a surgeon-scientist focused on translating novel biomaterials into impactful medical devices and technologies.

项目概要 在美国，大约每 100 名出生的儿童中就有 1 名患有先天性心脏病 (CHD)。 这些儿童中有四分之一患有“严重”先心病，需要在生命的第一年内进行手术干预。 对于因冠心病而导致肺动脉高压的患者（例如，血液不受限制地流向肺动脉） 肺），姑息性肺动脉带（PAB）可用于调节血流。 如果由于血流动力学需要调整，则需要对儿童进行重复手术 和/或适应生长，因此，受影响的儿童患有高发病率和死亡率。 该提案通过开发和优化新型刺激响应材料来满足这一临床需求 与 PAB 集成以实现可调节性。 光是向 PAB 引入微创可重构性的理想刺激。 这项研究活动是将光响应材料与 PAB 集成，使 PAB 的直径能够 通过血管内光纤导管穿过动脉壁传输的光进行重新配置。目标 1 是。 专注于材料开发和集成到利用刺激响应的新型 PAB 设计中 目标 2 将评估细胞和宿主对刺激响应材料的反应并开发。 必要时设计这些反应的策略从长远来看，刺激响应材料将不断发展。 催生出各种适应生长和变形的医疗设备，以改善患者的健康状况 结果和生活质量。 该合作研究项目将在科罗拉多大学博尔德分校与 Timothy White 博士和 Kristi Anseth 博士的指导和支持 培训计划包括发展。 技术技能（例如高分子化学、医疗器械设计和生物材料的生物测试）以及 专业技能（例如沟通技巧、职业发展和科学推广）。 申请将为申请人作为外科医生科学家的未来职业生涯提供宝贵的培训 将新型生物材料转化为有影响力的医疗设备和技术。

项目成果

Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment.

硬度各向异性协调细胞上收缩力，驱动长距离肌管-ECM 对齐。

• DOI: 10.1101/2023.08.08.552197
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Skillin,NathanielP;Kirkpatrick,BruceE;Herbert,KatieM;Nelson,BenjaminR;Hach,GraceK;Günay,KemalArda;Khan,RyanM;DelRio,FrankW;White,TimothyJ;Anseth,KristiS
• 通讯作者: Anseth,KristiS