Developing near-infrared responsive liquid crystal elastomers for an adjustable pulmonary artery band

开发用于可调节肺动脉带的近红外响应液晶弹性体

• 批准号: 10537663
• 负责人: Nathaniel Phillip Skillin
• 金额: $ 4.16万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-17 至 2026-08-16
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10537663
• 关键词: 3D Print; Acute; Address; Adopted; Affect; Animals; Arteries; Biocompatible Materials; Biological Testing; Blood; Blood Circulation; Blood flow; Body Weight; Caliber; Cardiac; Catheters; Cell Culture Techniques; Cells; Cessation of life; Child; Chronic; Clinical; Colorado; Communication; Congenital Heart Defects; Critical Congenital Heart Defects; Defect; Development; Devices; Echocardiography; Elastomers; Elements; Engineering; Evolution; Exhibits; Fellowship; Fiber Optics; Future; Goals; Gold; Goretex; Growth; Health Care Costs; Immune response; Implant; In Vitro; Infant; International; Lasers; Life; Life Expectancy; Light; Lung; Mechanics; Mediating; Medical Device; Medical Device Designs; Medical Technology; Mentorship; Morbidity - disease rate; Mus; Near-Infrared Spectroscopy; Newborn Infant; Operative Surgical Procedures; Optics; Patient-Focused Outcomes; Patients; Penetration; Performance; Persons; Physiological; Polymer Chemistry; Polymers; Prevalence; Procedures; Publishing; Pulmonary Hypertension; Pulmonary artery structure; Quality of life; Regulation; Repeat Surgery; Reporting; Research Activity; Research Project Grants; Research Proposals; Research Training; Risk; Scientist; Shapes; Skin; Source; Stimulus; Sum; Surface; Surface Properties; Surgeon; Technical Expertise; Techniques; Testing; Tissues; Training; Translating; Translations; Transmission Electron Microscopy; United States; Universities; Work; base; biomaterial compatibility; cancer therapy; career; career development; constriction; cost; crosslink; cytotoxicity; cytotoxicity test; design; global health; hemodynamics; implantation; improved; improved outcome; in vivo; irradiation; light scattering; liquid crystal; medical implant; minimally invasive; mortality; nanocomposite; nanorod; novel; outreach; palliate; palliation; palliative; patient prognosis; performance tests; preclinical study; pressure; response; scaffold; skills; subcutaneous; surgery material; tool

Project Summary Approximately 1 in 100 children born in the United State have a congenital heart defect (CHD). Nearly a quarter of these children present with “critical” CHDs, requiring surgical intervention within the first year of life. For patients in which a CHD is the source of pulmonary hypertension (e.g., the unrestricted flow of blood to the lungs), a palliative pulmonary artery band (PAB) can be applied to regulate blood flow. Conventional PABs are fixed and thus commit children to repeated surgeries if adjustments are needed due to altered hemodynamics and/or to accommodate growth. As a result, the affected children suffer from high morbidity and mortality. This proposal addresses this clinical need by developing and optimizing novel stimuli-responsive materials for integration with PABs to permit adjustability. Light is an ideal stimulus to introduce minimally invasive reconfigurability to the PAB. The objective of this research activity is to integrate photoresponsive materials with PABs to enable the diameter of the PAB to be reconfigured via light delivered by an endovascular fiber-optic catheter through the artery wall. Aim 1 is focused on material development and integration into novel PAB designs that leverage the stimuli-responsive material. Aim 2 will assess the cellular and host responses to the stimuli-responsive material and develop strategies to engineer these responses if necessary. Long-term, the evolution of stimuli-responsive materials will lead to a wide variety of growth-accommodating and shape-changing medical devices that will improve patient outcomes and quality of life. This collaborative research project will be undertaken at the University of Colorado Boulder with mentorship and support from Dr. Timothy White and Dr. Kristi Anseth. The training plan includes development of technical skills (e.g. polymer chemistry, medical device design, and biological testing of biomaterials) and professional skills (e.g. communication skills, career development, and scientific outreach). In sum, this application will provide the applicant with invaluable training for his future career as a surgeon-scientist focused on translating novel biomaterials into impactful medical devices and technologies.

项目摘要 在美国出生的100名儿童中大约有1个患有先天性心脏缺陷（CHD）。几乎一个 这些儿童中有四分之一的“关键” CHD需要在生命的第一年内进行手术干预。 对于CHD是肺动脉高压来源的患者（例如，血液流向不受限制 肺），可以应用姑息性肺动脉带（PAB）来调节血流。常规的pab是 固定，因此如果需要改变血液动力学，需要调整，则可以重复手术进行重复手术 和/或适应增长。结果，受影响的儿童患有高发病率和死亡率。这 提案通过开发和优化新颖的刺激响应材料来解决这种临床需求 与PAB集成以允许可调节性。 光是将最小侵入性重构性引入PAB的理想刺激。目的 这项研究活动是将光反应材料与PAB整合在一起，以使PAB的直径达到 通过通过动脉壁通过血管内纤维的导管传递的光重新配置。目标1是 专注于材料开发并集成到利用刺激反应的新型PAB设计中 材料。 AIM 2将评估细胞和宿主对刺激反应材料的反应，并发展 如有必要，可以设计这些回应的策略。长期，刺激响应材料的演变将 导致各种各样的增长和改变形状的医疗设备，这些设备将改善患者 成果和生活质量。 该合作研究项目将在科罗拉多大学博尔德大学进行 蒂莫西·怀特（Timothy White）博士和克里斯蒂·安塞斯（Kristi Anseth）博士的遗传和支持。培训计划包括开发 技术技能（例如聚合物化学，医疗设备设计和生物材料的生物识别测试）和 专业技能（例如沟通技巧，职业发展和科学外展）。总而言之 申请将为他的未来职业提供以外科医生的培训为以外科医生的身份提供宝贵的培训 将新颖的生物材料转化为有影响力的医疗设备和技术。