The human amygdala in social processing: circuits physiology behavior and neuromodulation.

社会处理中的人类杏仁核：电路生理学行为和神经调节。

• 批准号: 9666633
• 负责人: Kelly Rowe Bijanki
• 金额: $ 14.87万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-21 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9666633
• 关键词: Address; Affective; Amygdaloid structure; Anterior; Arousal; Autonomic nervous system; Award; Basic Science; Behavior; Behavioral; Bioinformatics; Biological Neural Networks; Biometry; Brain; Clinical; Clinical Trials Design; Communication; Computers; Corpus striatum structure; Data; Depressed mood; Depressive disorder; Dimensions; Electric Stimulation; Electrical Stimulation of the Brain; Electrodes; Electrophysiology (science); Emotional; Emotions; Epilepsy; Etiology; Evaluation; Evoked Potentials; Eye; Face; Face Processing; Facial Expression; Foundations; Frequencies; Gestures; Goals; Human; Implant; Implanted Electrodes; Knowledge; Lead; Major Depressive Disorder; Maps; Measurement; Measures; Medical; Mental disorders; Mentors; Mentorship; Methods; Mind; Monitor; Motor Activity; National Institute of Mental Health; Neurobiology; Neurons; Operative Surgical Procedures; Participant; Patients; Perception; Performance; Physiological; Physiology; Play; Procedures; Production; Psychiatric Diagnosis; Reading; Refractory; Research; Research Domain Criteria; Research Ethics; Research Personnel; Role; Seizures; Social Functioning; Social Processes; Statistical Models; Structure; Structure of superior temporal sulcus; Synapses; System; Task Performances; Techniques; Testing; Time; Training; United States National Institutes of Health; Work; area striata; behavior measurement; cingulate cortex; emotional stimulus; experimental study; fusiform face area; mental state; neural circuit; neuroimaging; neuropsychiatry; neuroregulation; novel; programs; relating to nervous system; research study; response; social; social communication

SUMMARY: The purpose of the current proposal is to enable the PI to transition to independent research investigator, with expertise in electrophysiological analysis techniques to examine the real-time function of the emotional (affective) system. The proposed training plan includes structured mentoring, hands-on training in electrophysiology and bioinformatics, didactic coursework, and a rigorous proposed research study. The proposed experiments leverage a highly specialized experimental setting: human epilepsy patients with depth electrodes implanted in the amygdala – central to social and emotion processing – for routine seizure focus monitoring in medically refractory epilepsy. In this setting, we can record local neuronal activity as well as apply small electrical currents to stimulate for research purposes. The proposed training in electrophysiology will enable the PI to examine the real-time function of the amygdala, which, when paired with her existing expertise in human neuroimaging and psychiatric behavioral measurement, will allow a thorough comparison of amygdala connectivity and dynamics across patients with a wide range of social processing abilities. This project examines the hypothesis that the amygdala plays a direct and causal role in social processing. Within the NIMH RDoC Framework, the current proposal examines the role of the amygdala in the Domain of Social Processes, including the Construct of Social Communication and the Construct of Perception and Understanding of Others. We will examine these functions from the level of neural circuits, physiology, and behavior, and to examine the potential for amygdala neuromodulation to enhance social processing. Deeper understanding of the neural circuitry of social processing will facilitate the study and treatment of depressive disorders with implications for broader neuropsychiatric conditions as well. Results of this project will provide pilot data for an NIMH R01 application, and compliment the ongoing work of the applicant and the mentorship team. Coursework will include didactic, and hands-on training in electrophysiological analysis, didactic training in advanced statistical modeling to build upon the applicant’s current training in biostatistics and clinical trials design, and continued training in research ethics. Therefore, this award would allow the PI to accomplish her goal of becoming an independent, academic research investigator, while advancing the research objective of evaluating the causal role of the amygdala in social processing.

概括： 当前提案的目的是使PI能够过渡到独立研究 调查员，具有电生理分析技术的专业知识来检查实时 所提出的培训计划包括结构化的情感（情感）系统功能。 指导、电生理学和生物信息学实践培训、教学课程，以及 拟议的严格研究利用了高度专业化的实验。 实验环境：人类癫痫患者杏仁核植入深度电极 – 社交和情绪处理的核心 – 用于医学领域的常规癫痫焦点监测 在这种情况下，我们可以记录局部神经元活动并应用小信号。 电流刺激用于研究目的。 电生理学将使 PI 能够检查杏仁核的实时功能， 与她在人类神经影像学和精神病学行为方面现有的专业知识相结合 测量，将允许对杏仁核的连接性和动态进行彻底的比较 该项目检验了这一假设。 杏仁核在社会处理中起着直接和因果的作用。 在 NIMH RDoC 框架内，当前提案研究了杏仁核在 社会过程领域，包括社会交往的构建和 我们将从他人的感知和理解的构建来研究这些功能。 神经回路、生理学和行为水平，并检查杏仁核的潜力 神经调节以增强对神经回路的更深入理解。 社会处理将促进抑郁症的研究和治疗，并产生影响 该项目的结果也将为更广泛的神经精神疾病提供试点数据。 NIMH R01 申请，并赞扬申请人正在进行的工作和指导 团队的课程工作将包括电生理分析的教学和实践培训， 高级统计模型的教学培训以申请人当前的培训为基础 生物统计学和临床​​试验设计，以及研究伦理方面的持续培训。 该奖项将使 PI 能够实现成为一名独立的学术人员的目标 研究调查员，同时推进评估因果作用的研究目标 杏仁核在社会处理中的作用。