Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)

肺试验合作组织 (PTC) 的网络管理核心 (NEMO)

• 批准号: 9757805
• 负责人: FRANK SCIURBA
• 金额: $ 429.14万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9757805
• 关键词: Accreditation; Address; American; Area; Bioinformatics; Budgets; Categories; Characteristics; Chronic; Chronic lung disease; Classification; Clinical; Clinical Data; Clinical Management; Clinical Services; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Communication; Communities; Complex; Computerized Medical Record; Coordination and Collaboration; Diagnostic radiologic examination; Discipline; Disease; Documentation; Enrollment; Ensure; Evaluation; Foundations; Funding; Goals; Health Sciences; Infrastructure; Inpatients; Institution; Institutional Review Boards; Investments; Leadership; Letters; Lung; Lung diseases; Measurement; Medical; Modeling; Morbidity - disease rate; Multicenter Studies; National Heart, Lung, and Blood Institute; Obstructive Sleep Apnea; Outcome; Outpatients; Pathologist; Patients; Physiological; Population; Principal Investigator; Privatization; Productivity; Protocols documentation; Public Health; Registries; Reporting; Request for Applications; Research; Research Personnel; Structure; Supervision; System; Techniques; Testing; Therapeutic Agents; Time; Tissue Banks; United States National Institutes of Health; Universities; Work; base; biobank; cohort; college; cooperative study; design; drug distribution; epidemiologic data; experience; innovation; interest; mortality; novel; novel strategies; novel therapeutics; operation; patient population; programs; public health relevance; recruit; response

 DESCRIPTION (provided by applicant): In response to Request for Applications (RFA) RFA-HL-15-016, the University of Pittsburgh proposes to establish the Network Management Core (NEMO) of the Pulmonary Trials Cooperative (PTC). In addition to the NEMO, the PTC will include up to three Protocol Leadership Groups (PLGs), a Data and Safety Monitoring Board (DSMB), representatives from the NHLBI, a Steering Committee (with a chair appointed by the NHLBI), and various subcommittees to the Steering Committee. The NEMO will bring together substantive and management expertise. The Principal Investigators, Dr. Stephen Wisniewski and Frank Sciurba are experienced in the conduct and administration of complex multi-center studies. An exemplary team of co- investigators with expertise across the spectrum of lung diseases have been identified and well established relationships within the lung community to facilitate access to the necessary subject populations. With this experience comes an understanding of the responsibilities of the NEMO for the PTC as well as an understanding of the commitments associated with being the NEMO for a large collaborative network. The overarching goal of the NEMO is to encourage and facilitate collaboration, sharing, interaction, and research within the PTC. The specific aims of the NEMO are: Aim 1. Provide scientific input on the design, conduct, and analysis of PTC studies. Aim 2. Provide administrative support for the PTC Aim 3. Implement systems to ensure the highest quality studies Aim 4. Develop systems to provide seamless communications among PTC investigators Aim 5. Serve as a biorepository for the PTC Aim 6. Support future research endeavors of the PTC.

 描述（由申请人提供）：为了响应申请请求（RFA）RFA-HL-15-016，匹兹堡大学提议除肺试验合作组织（PTC）外还建立网络管理核心（NEMO）。 NEMO、PTC 将包括最多三个协议领导小组 (PLG)、一个数据和安全监控委员会 (DSMB)、来自 NHLBI 的代表、一个指导委员会（任命一名主席） NEMO 的各个小组委员会将汇集实质性和管理方面的专业知识。已经确定了具有各种肺部疾病专业知识的联合研究人员团队，并在肺部社区内建立了良好的关系，以促进接触必要的受试者人群。有了这些经验，人们就了解了 NEMO 对 PTC 的责任。以及了解与成为大型协作网络的 NEMO 相关的承诺。 NEMO 的总体目标是鼓励和促进 PTC 内的协作、共享、互动和研究。 NEMO 的具体目标是：目标 1. 为 PTC 研究的设计、实施和分析提供科学意见 目标 2. 为 PTC 提供行政支持 目标 3. 实施系统以确保最高质量的研究 目标 4. 开发系统以在 PTC 之间提供无缝通信。研究人员 目标 5. 充当 PTC 的生物样本库 目标 6. 支持 PTC 未来的研究工作。

项目成果

The Hypoglossal Nerve Stimulation as a Novel Therapy for Treating Obstructive Sleep Apnea-A Literature Review.

舌下神经刺激作为治疗阻塞性睡眠呼吸暂停的新疗法 - 文献综述。

• 发表时间: 2021
• 作者: Mashaqi, Saif;Patel, Salma Imran;Combs, Daniel;Estep, Lauren;Helmick, Sonia;Machamer, Joan;Parthasarathy, Sairam
• 通讯作者: Parthasarathy, Sairam

The Association Between Obstructive Sleep Apnea Characterized by a Minimum 3 Percent Oxygen Desaturation or Arousal Hypopnea Definition and Hypertension.

以至少 3% 的氧饱和度下降或唤醒性呼吸不足定义为特征的阻塞性睡眠呼吸暂停与高血压之间的关联。

• 发表时间: 2019-09-15
• 作者: Budhiraja, Rohit;Javaheri, Sogol;Parthasarathy, Sairam;Berry, Richard B;Quan, Stuart F
• 通讯作者: Quan, Stuart F