LTRC CLINICAL CENTER

LTRC 临床中心

• 批准号: 8429134
• 负责人: FRANK SCIURBA
• 金额: $ 71.28万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-03 至 2015-01-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429134
• 关键词: Blood specimen; Cancer Patient; Chronic Obstructive Airway Disease; Clinical Data; Connective Tissue Diseases; Data; Disease; Enrollment; Excision; Future; Hamman-Rich syndrome; Interstitial Lung Diseases; Interstitial Pneumonia; Lung; Lung diseases; National Heart, Lung, and Blood Institute; Nodule; Pathogenesis; Patients; Physiological; Research; Research Personnel; Respiratory physiology; Structure of parenchyma of lung; Tissue Sample; Tissues

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiologic studies, and radiographic studies from patients with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic interstitial pneumonias (IIP) and interstitial pneumonias associated with connective tissue diseases who undergo medically-indicated lung resection. For the purpose of comparison, lung tissue and similar clinical data will be collected from control subjects who require lung resection. These control subjects will primarily come from cancer patients without poor lung function for whom non-neoplastic tissue can be collected remotely from a nodule or mass and may also come from patients enrolled with suspected interstitial lung disease (ILD) who are shown after pathological examination not to have this disease. All tissue and blood specimens and clinical data will be banked and stored for distribution to future investigators who have approved study proposals and are investigating the pathogenesis of the aforementioned lung diseases.

国家心肺和血液研究所 (NHLBI) 肺组织研究联盟 (LTRC) 成立的主要目的是收集肺组织和血液样本，次要目的是收集临床数据、有限暴露数据、生理研究和放射学研究患有慢性阻塞性肺疾病（COPD）、特发性肺纤维化（IPF）、其他相关特发性间质性肺炎（IIP）以及与结缔组织疾病相关的间质性肺炎的患者接受医学上指示的肺切除术。为了进行比较，将从需要肺切除术的对照受试者中收集肺组织和类似的临床数据。这些对照受试者主要来自肺功能较差的癌症患者，可以从结节或肿块远程采集非肿瘤组织，也可能来自疑似间质性肺疾病（ILD）的患者，这些患者在病理检查后显示未发现肺功能不良。得这种病。所有组织和血液标本以及临床数据都将被储存起来，以便分发给未来的研究人员，这些研究人员已批准研究提案并正在研究上述肺部疾病的发病机制。