Res Div Suppl (Lisbeth Iglesias-Rios): Maternal ethylenethiourea levels, newborn thyroid function & infant development

Res Div Suppl (Lisbeth Iglesias-Rios)：母体乙烯硫脲水平、新生儿甲状腺功能

• 批准号: 9757527
• 负责人: Alexis Handal
• 金额: $ 8.37万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-07 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9757527
• 关键词: Affect; Age-Months; Agriculture; Area; Award; Behavioral; Biological Markers; Birth; Blood specimen; Brain; Child; Child Development; Child Health; Clinical Treatment; Cognitive; Communities; Data; Demographic Factors; Development; Economic Factors; Economics; Ecuador; Enrollment; Environmental Epidemiology; Environmental Exposure; Ethylenethiourea; Exposure to; Female; Fetal Growth Retardation; Functional disorder; Funding; Future; Goals; Growth; Health; Health Policy; Home environment; Hormones; Impaired cognition; Industrial fungicide; Industry; Infant; Infant Development; Intervention; Knowledge; Language; Maternal Health; Measures; Mediating; Mental Depression; Mental Health; Motor; Neonatal; Neuraxis; Newborn Infant; Nutritional status; Occupational Epidemiology; Outcome; Parents; Pesticides; Population; Postpartum Period; Poverty; Pregnancy; Pregnancy loss; Pregnant Women; Premature Birth; Production; Reproductive Health; Research; Research Activity; Running; Sampling; Serum; Social Processes; Social support; Stress; Sum; Surveys; Teratogens; Testing; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroxine; Toxic effect; Toxicant exposure; Training; United States; Urine; Validation; Vision; Visit; Visual; adverse outcome; carcinogenicity; career; epidemiology study; experience; fetal; global health; improved; lifestyle factors; maternal depression; maternal stress; neurobehavioral; nutrition; pregnant; prenatal; prenatal exposure; professional atmosphere; screening; social; socioeconomics; therapy development; urinary

Abstract of funded parent award R01ES026603: Maternal ethylenethiourea levels, newborn thyroid function & infant development An estimated 1 in 6 children in the U.S. and over 200 million children in the developing world are not reaching their full developmental potential. Although fungicide use is growing exponentially in the United States and globally, a significant gap exists in scientific knowledge about the neurodevelopmental toxicity of fungicides. Ethylenebisdithiocarbamates, or EBDCs, are commonly-used fungicides in agricultural production as well as in floriculture and horticulture. EBDCs are metabolized into a more toxic carcinogenic and teratogenic compound, ethylenethiourea (ETU), which has been associated with decreased serum thyroxine levels, increased thyroid stimulation hormone levels, and thyroid gland disorders. Although research indicates that prenatal ETU exposure may cause maternal and neonatal thyroid dysfunction, potentially leading to adverse outcomes including pregnancy loss, preterm delivery, intrauterine growth restriction, disruptions in fetal central nervous system and brain development and impaired cognitive and motor function, no epidemiological studies to date have evaluated the effects of prenatal exposure to ETU on newborn thyroid function or the subsequent neurobehavioral development of infants. This study proposes to follow pregnant women and their infants, incorporating prenatal urinary biomarkers of ETU exposure, survey data of environmental ETU exposure and key social and economic factors, and sensitive growth and neurobehavioral developmental measures. We hypothesize that higher maternal urinary ETU levels during pregnancy will be associated with delayed growth measures and lower cognitive, visual, and psychomotor developmental assessment scores at birth, 6, 12, and 18 months of age and that this association will be mediated through an impact on newborn thyroid function. The proposed research takes advantage of a unique opportunity to investigate this question in a highly exposed population in Ecuador. We will enroll 420 pregnant women at 10-12 weeks gestation and follow them through pregnancy up to 18 months post-partum. We will obtain monthly prenatal urine samples. We will obtain neonatal blood samples to assess thyroid hormone levels at birth. We will administer highly sensitive tests (BSID-III, Teller cards) that will assess cognitive, motor, language, and social-behavioral development, and visual function in infants. Infants will also be measured for growth and nutritional status. At each visit throughout the study, data will be collected on working conditions, stress, environmental exposures in home and work environments, social support, maternal health and lifestyle factors, socio-economic and demographic factors. We will quantify levels of prenatal ETU exposure and will analyze levels by trimester. We will assess associations between prenatal urinary ETU metabolite levels and infant developmental outcomes and will run a multivariate path analysis to test for a mediating effect of newborn thyroid dysfunction on this association. This study will further scientific understanding of the developmental consequences of exposure to fungicides, which have become the most commonly used pesticides in the agricultural industry in the U.S. and globally. In sum, environmental toxic exposure, poor nutrition, poverty, maternal depression and stress, and other social and economic factors contribute to the loss of developmental potential in young children. The proposed study will contribute key data to inform our understanding of how these factors impact child development. This data will be critical for developing and initiating appropriate and sustainable interventions in affected communities that promote optimal child health and development, reduce environmentally-associated community exposures, and improve worker health policies.

资助家长奖摘要 R01ES026603：母亲乙撑硫脲水平、新生儿甲状腺功能和婴儿 发展 据估计，美国有六分之一的儿童和发展中国家有超过 2 亿的儿童 没有充分发挥其发展潜力。尽管杀菌剂的使用呈指数级增长 美国和全球范围内，有关该疾病的科学知识存在显着差距 杀菌剂的神经发育毒性。亚乙基双二硫代氨基甲酸酯 (EBDC) 是 农业生产以及花卉园艺中常用的杀菌剂。 EBDC 被代谢成毒性更强的致癌和致畸化合物， 亚乙基硫脲（ETU）与血清甲状腺素水平降低有关， 促甲状腺激素水平升高和甲状腺疾病。虽然研究 表明产前 ETU 暴露可能导致孕产妇和新生儿甲状腺功能障碍， 可能导致不良后果，包括流产、早产、宫内流产 生长受限，胎儿中枢神经系统和大脑发育受到破坏并受损 认知和运动功能，迄今为止还没有流行病学研究评估过 产前暴露于 ETU 对新生儿甲状腺功能或随后神经行为的影响 婴儿的发育。这项研究建议追踪孕妇及其婴儿， 纳入 ETU 暴露的产前尿液生物标志物、环境 ETU 调查数据 暴露和关键社会和经济因素，以及敏感的生长和神经行为 发展措施。我们假设孕产妇尿 ETU 水平较高 怀孕会导致生长迟缓以及认知、视力和认知能力下降。 出生时、6个月、12个月和18个月时的精神运动发育评估分数 这种关联将通过对新生儿甲状腺功能的影响来介导。拟议的 研究利用一个独特的机会在高度暴露的情况下调查这个问题 厄瓜多尔人口。我们将招募 420 名妊娠 10-12 周的孕妇并进行跟踪 他们从怀孕到产后 18 个月。我们将每月采集产前尿液 样品。我们将获取新生儿血液样本来评估出生时的甲状腺激素水平。我们 将进行高度敏感的测试（BSID-III、柜员卡），评估认知、运动、 婴儿的语言、社会行为发展和视觉功能。婴儿也会 测量生长和营养状况。在整个研究的每次访问中，数据将被 收集有关家庭和工作中的工作条件、压力、环境暴露的信息 环境、社会支持、孕产妇健康和生活方式因素、社会经济和 人口因素。我们将量化产前 ETU 暴露水平，并通过以下方式分析水平： 三个月。我们将评估产前尿液 ETU 代谢水平与婴儿之间的关联 发展结果，并将运行多变量路径分析来测试以下因素的中介效应： 新生儿甲状腺功能障碍与此有关联。这项研究将进一步加深科学认识 接触杀菌剂对发育的影响，这已成为最严重的问题 美国和全球农业中常用的农药。 总之，环境有毒物质暴露、营养不良、贫困、孕产妇抑郁和压力， 以及其他社会和经济因素导致年轻人丧失发展潜力 孩子们。拟议的研究将提供关键数据，以帮助我们了解这些 影响儿童发展的因素。这些数据对于制定和启动适当的 以及在受影响社区采取可持续干预措施，促进最佳儿童健康和 发展，减少与环境相关的社区暴露，并改善工人 卫生政策。