APPLYING BIOINFORMATICS AND COMPUTATIONAL BIOLOGY TO STUDY HIV/AIDS

应用生物信息学和计算生物学研究艾滋病毒/艾滋病

• 批准号: 7715382
• 负责人: Tsegaye Habtemariam
• 金额: $ 5.42万
• 依托单位: TUSKEGEE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-16 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715382
• 关键词: AIDS epidemiology; AIDS/HIV problem; African American; Alabama; Behavioral; Bioinformatics; Clinic; Communities; Computational Biology; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Data; Development; Disease; Epidemiologic Studies; Epidemiology; Funding; Future; Grant; Highly Active Antiretroviral Therapy; Infection; Infection prevention; Institution; Intervention; Journals; Manuscripts; Modeling; Molecular; Outcome; Population; Preventive; Research; Research Personnel; Resources; Risk; Socioeconomic Factors; Source; System; Therapeutic; United States National Institutes of Health; Universities; Work; health disparity; insight; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses upon Research in Computational Epidemiology with an emphasis on a health disparity disease of major concern, that of HIV/AIDS. SPECIFIC AIMS: 1) Development of a novel micro-epidemiologic computational model for HIV/AIDS at the intracellular levels: The models developed provide insights in how an intracellular/molecular level model can be incorporated within a macro-epidemiologic integrative systems dynamics model for examining a variety of computational experimentations. 2) Development of a systems dynamics model and modelling of the multifactorial epidemiology of HIV/AIDS. An epidemiologic model that incorporates cellular/molecular (micro level) and macro level epidemiologic dynamics for examining preventive and therapeutic strategies of HIV/AIDS in African American sub populations was developed. 3) Modelling of the multifactorial epidemiology of HIV/AIDS: Multifactorial and quantitative epidemiologic studies that interrelate (biomedical, behavioral, and socioeconomic factors) determinants have been developed. Using these models as our experimental medium, we evaluate various intervention scenarios to recommend effective strategies for the community to minimize the risk of new infections prevent future infections and manage existing infections. 4) Static modeling to examine if HAART Therapies for HIV/AIDS. To answer the question of which combination of HAART is most effective we collaborated with the University of Alabama at Birmingham (UAB) 1917 HIV/AIDS clinic. The results of this work although appeared promising in the beginning, they did not provide clear and reliable outcomes. STUDIES AND RESULTS: Manuscripts are being prepared for submission to journals. PLANS: To continue to gather data and information for the estimation of the parameters and variables of the model for HIV/AIDS with a focus on the macro-epidemiology of AIDS in African Americans.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目着重于计算流行病学研究，重点是主要关注的健康差异疾病，即艾滋病毒/艾滋病。具体目的：1）开发在细胞内级别的HIV/AIDS的新型微型人体学计算模型：开发的模型提供了有关如何将细胞内/分子水平模型纳入宏观电子学集成系统动力学模型，以检查各种计算实验。 2）开发系统动力学模型和HIV/AIDS多因素流行病学的建模。开发了一种流行病学模型，该模型融合了非裔美国人亚种群中艾滋病毒/艾滋病的预防性和治疗策略的细胞/分子（微水平）和宏观水平流行病学动力学。 3）艾滋病毒/艾滋病多因素流行病学的建模：已经开发了相互关联（生物医学，行为和社会经济因素）决定因素的多因素和定量流行病学研究。我们以这些模型为实验媒介，评估各种干预方案，为社区推荐有效的策略，以最大程度地减少新感染的风险，以防止未来感染并管理现有感染。 4）静态建模，以检查HAART疗法是否用于HIV/AIDS。要回答我们与阿拉巴马大学伯明翰大学（UAB）1917年HIV/艾滋病诊所合作的HAART最有效的问题。 这项工作的结果虽然一开始似乎很有希望，但他们没有提供明确可靠的结果。 研究和结果：正在准备提交期刊的手稿。计划：继续收集数据和信息，以估算艾滋病毒/艾滋病模型的参数和变量，重点是非洲裔美国人的艾滋病宏观流行病学。