Nicaraguan Emerging and Endemic Diseases (NEED) Training Program

尼加拉瓜新发和地方病 (NEED) 培训计划

• 批准号: 9884834
• 负责人: Sylvia Irene Becker-Dreps
• 金额: $ 24.62万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-10 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9884834
• 关键词: Accreditation; Address; Affect; Bilateral; Biomedical Research; Calicivirus; Caribbean region; Chikungunya virus; Childhood; Dengue; Diarrhea; Disease Outbreaks; Doctor of Philosophy; Endemic Diseases; Enrollment; Ensure; Faculty; Fostering; Growth; Infectious Disease Epidemiology; Influenza; Institution; Interdisciplinary Study; Latin America; Lung diseases; Mentors; Microbiology; Morbidity - disease rate; Nicaragua; Nicaraguan; North Carolina; Pattern; Prevalence; Public Health; Research; Research Personnel; Research Project Grants; Research Training; Respiratory syncytial virus; Risk; Science; Scientist; Serotyping; Training; Training Programs; Universities; Viral Epidemiology; Virus; Virus Diseases; Yellow fever virus; Zika Virus; biomedical scientist; burden of illness; cohort; design; evidence base; faculty research; innovation; laboratory experience; low and middle-income countries; mortality; pathogen; pathogenic virus; population health; pre-doctoral; programs; skill acquisition; skills; success

Contact PD/PI: Becker-Dreps, Sylvia Abstract t The growing, global impact of emerging and endemic viral diseases is a critical public health issue. The explosive spread of zika virus throughout Latin America and the Caribbean in 2015 followed only two years after a similar pattern of spread of chikungunya virus. In 2017, yellow fever virus from Amazon regions emerged in Rio de Janeiro, underscoring the risk of a major urban outbreak. In addition to these emerging and reemerging viruses, endemic viruses continue to cause a high burden of disease. Caliciviruses are now the leading causes of childhood diarrhea in Nicaragua, influenza and respiratory syncytial virus continue to cause a high burden of respiratory disease, and all four dengue serotypes are now endemic. We have designed a program to train a cadre of innovative scientists in Nicaragua to confront these emerging and endemic pathogens of high priority to the LMIC institution. The rationale for this program is to protect the public health of populations by increasing the numbers and expertise of local scientists to 1) describe the epidemiology of these viral pathogens, 2) understand their impact on morbidity and mortality, and 3) identify evidence-based approaches to reduce their prevalence and burden of disease. The Nicaraguan Emerging and Endemic Diseases (NEED) Training Program takes advantage of the convergence of a longstanding relationship between Universidad Nacional Autónoma de Nicaragua, León (UNAN-León) and the University of North Carolina at Chapel Hill (UNC), existing collaborative research for trainee projects, and strong bilateral institutional support. The program’s objectives include: 1) Provide long-term, pre-doctoral training in infectious disease epidemiology at UNC to two young investigators from UNAN-León. These graduates will contribute to the core research faculty at UNAN-León to address pressing local research agendas; 2) Create a sustainable supply of well-trained biomedical scientists in the region by establishing an accredited PhD program in Biomedical Sciences at UNAN- León; we will enroll five pre-doctoral candidates in the initial cohort. This program builds upon a successful Master’s program of Microbiology in place at UNAN-León and fills a huge need in Nicaragua for rigorous PhD- level biomedical research training. We further support five of these pre-doctoral trainees for one-month long laboratory trainings at UNC. 3) Foster professional growth and research skills development among 140 trainees of all levels, including local faculty, to ensure academic and research success. Robust short-term trainings in professional and research skills needed to become an independent investigator and successful academician are provided to both trainees and local faculty to ensure that the program’s impacts extend more broadly. This program will result in a multidisciplinary research team at UNAN-Leon to confront the emerging and endemic viral diseases that affect public health both regionally and globally. Our approach is made feasible by leveraging an existing successful Master’s program at UNAN-León and by providing trainees the opportunity to partner with mentors at both UNC and UNAN-León on a growing array of collaborative research projects.

联系人 PD/PI：Becker-Dreps、Sylvia 抽象的 t 新出现的地方性病毒性疾病对全球的影响日益扩大，是一个重要的公共卫生问题。 2015 年，寨卡病毒在整个拉丁美洲和加勒比地区传播，而仅仅两年后，类似的情况就发生了。 基孔肯雅病毒的传播模式 2017 年，来自亚马逊地区的黄热病病毒在里约热内卢出现。 内卢强调，除了这些新出现和重新出现的病毒外，还存在大规模城市疫情爆发的风险。 地方性病毒继续造成沉重的疾病负担，目前杯状病毒是导致疾病的主要原因。 尼加拉瓜儿童腹泻、流感和呼吸道合胞病毒继续造成沉重负担 呼吸道疾病，所有四种登革热血清型现在都是地方性的，我们设计了一个计划来培训登革热病毒。 尼加拉瓜的创新科学家骨干队伍将应对这些高度优先的新兴和地方性病原体 中低收入国家机构的基本原理是通过增加 当地科学家的数量和专业知识，以 1) 描述这些病毒病原体的流行病学，2) 了解 它们对发病率和死亡率的影响，以及 3) 确定降低其患病率的循证方法 尼加拉瓜新发和地方病 (NEED) 培训计划需要 得益于与国立自治大学之间长期合作关系的融合 尼加拉瓜、莱昂 (UNAN-León) 和北卡罗来纳大学教堂山分校 (UNC)，现有合作 实习生项目研究以及强有力的双边机构支持 该计划的目标包括：1) 在北卡罗来纳大学为两名年轻人提供长期的传染病流行病学博士前培训 这些毕业生将为 UNAN-León 的核心研究人员做出贡献。 解决紧迫的当地研究议程；2）创造训练有素的生物医学的可持续供应； 通过在UNAN建立生物医学科学博士项目来吸引该地区的科学家 León；我们将在最初的队列中招收五名博士前候选人。 莱昂国立大学微生物学硕士课程满足了尼加拉瓜对严谨的博士生的巨大需求 我们进一步支持其中五名博士生进行为期一个月的生物医学研究培训。 北卡罗来纳大学实验室培训 3) 促进 140 人的专业成长和研究技能发展。 各级学员，包括当地教师，以确保学术和研究的短期成功。 成为一名独立调查员并取得成功所需的专业和研究技能培训 为学员和当地教师提供院士，以确保该计划的影响范围扩大到更多 广泛而言，该计划将在莱昂国立大学建立一个多学科研究团队来应对新兴的问题。 我们的方法是可行的。 通过利用莱昂大学现有成功的硕士课程并为学员提供机会 与北卡罗来纳大学和莱昂国立大学的导师合作开展越来越多的合作研究项目。