Development of a 3D multi-modal perfusion-thermal electrode system

3D多模态灌注热电极系统的开发

基本信息

批准号：
9886241
负责人：
XIAOMING YANG
金额：
$ 62.76万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9886241
关键词：
3-Dimensional Ablation Achievement Address Animal Model Cell membrane Cells Clinical Development Dose Electrodes Embolism Ensure Fracture Genes Goals Heat shock proteins Heating Hyperthermia Immunotherapy Intervention Length of Stay Lesion Liver Liver neoplasms Malignant - descriptor Malignant Neoplasms Membrane Metabolism Methods Microsatellite Repeats Modeling Neoplasm Metastasis Organ Oryctolagus cuniculus Pathway interactions Patients Perfusion Peripheral Permeability Primary Neoplasm Protocols documentation Pump Quality of life Radiofrequency Interstitial Ablation Recurrence Recurrent disease Residual Tumors Residual state Risk Safety Series Solid Source Structure Surgical margins System Techniques Technology Temperature Testing Therapeutic Therapeutic Agents Therapeutic Intervention Thermal Ablation Therapy Tissues Treatment Failure Tumor Tissue Unresectable Venous advanced system antitumor agent biomaterial compatibility cost effectiveness design experimental study gene therapy image guided image guided intervention improved in vivo innovation microwave ablation minimally invasive multimodality neoplastic cell novel pre-clinical preclinical study prevent radiofrequency hyperthermia success technique development technology development tool tumor tumor ablation

项目摘要

Summary/Abstract: Title: Development of a 3D multi-modal perfusion-thermal electrode system Advances in image-guided interventional technologies have greatly improved the management of malignancies in patients. Among different interventional oncologic techniques, thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), have become the principal tools for treatment of unresectable primary and metastatic malignancies. However, tumor recurrence post- thermal ablation of medium (3-5 cm) to large (5-7 cm) lesions often occurs due to incomplete ablation of tumor margins. To date, there is no an ideal image-guided interventional method for effective management of medium-to-large solid organ malignancies. This project is specifically designed to conquer the critical clinical problem ─ persistence or recurrence of medium-to-large malignancies post-thermal ablation, by development of a novel three- dimensional (3D) multi-modal perfusion-thermal electrode system. To this end, we have proposed two specific goals: (1) Aim I: to design and develop the novel 3D multi-modal perfusion-thermal electrode system that is specifically built for using RFA-induced peri-tumoral RF hyperthermia (RFH) to enhance direct chemotherapeutic destruction of tumor margins; and (2) Aim II: to validate the technical feasibility of the new multi-modal electrode system with optimizing the technical protocols via serial preclinical studies in living animal models with orthotopic liver tumors. As the first step of the new technique development, we will primarily focus on the treatment of hepatic tumors by using first- line chemotherapeutics. If successful, we will extend its application in treating malignancies to other organs with more advanced therapies, such as gene therapy and immunotherapy. The success of this project will revolutionize current thermal ablation technology, leading to significant advancement in eradicating medium-to-large malignant lesions, not only in the liver but also in other solid organs. This will, in turn, greatly improve survival and quality of life of patients suffering from medium-to-large malignancies.

摘要/摘要：标题：3D多模态灌注热电极系统的开发图像引导介入技术的进步极大地改善了患者的管理在不同的介入肿瘤技术中，热消融等。射频消融（RFA）和微波消融（MWA）已成为治疗疾病的主要工具。治疗不可切除的原发性和转移性恶性肿瘤，但术后肿瘤复发。中等（3-5厘米）到大（5-7厘米）病灶的热消融常因消融不完全而发生迄今为止，还没有一种理想的有效的图像引导介入方法。中型至大型实体器官恶性肿瘤的治疗。这个项目是专门为克服关键的临床问题而设计的——持久性或通过开发一种新型的三-热消融后中型至大型恶性肿瘤的复发为此，我们提出了两种多维（3D）多模态灌注热电极系统。具体目标：（1）目标一：设计开发新型3D多模态灌注热电极该系统专门用于使用 RFA 诱导的肿瘤周围射频热疗 (RFH) 增强对肿瘤边缘的直接化疗破坏；以及 (2) 目标 II：验证优化技术方案的新型多模式电极系统的技术可行性通过对原位肝肿瘤活体动物模型进行一系列临床前研究。新技术的开发，我们将主要关注肝脏肿瘤的治疗，首先如果成功的话，我们将把它在治疗恶性肿瘤方面的应用扩展到其他领域。器官接受更先进的疗法，例如基因疗法和免疫疗法。该项目的成功将彻底改变当前的热消融技术，从而在消除中型至大型恶性病变方面取得了重大进展，不仅在肝脏中，而且在反过来，这也将大大提高患者的生存率和生活质量。患有中型至大型恶性肿瘤。